Gordon Guyatt
McMaster University
H-index: 296
North America-Canada
Professor Information
University | McMaster University |
---|---|
Position | Professor of Medicine |
Citations(all) | 412618 |
Citations(since 2020) | 158752 |
Cited By | 330364 |
hIndex(all) | 296 |
hIndex(since 2020) | 166 |
i10Index(all) | 1602 |
i10Index(since 2020) | 1123 |
University Profile Page | McMaster University |
Research & Interests List
Evidence-based medicine
Top articles of Gordon Guyatt
Systematic Reviews and Meta-analyses of the Procedure-specific Risks of Thrombosis and Bleeding in General Abdominal, Colorectal, Upper Gastrointestinal, and …
Objective:To provide procedure-specific estimates of symptomatic venous thromboembolism (VTE) and major bleeding after abdominal surgery.Background:The use of pharmacological thromboprophylaxis represents a trade-off that depends on VTE and bleeding risks that vary between procedures; their magnitude remains uncertain.Methods:We identified observational studies reporting procedure-specific risks of symptomatic VTE or major bleeding after abdominal surgery, adjusted the reported estimates for thromboprophylaxis and length of follow-up, and estimated cumulative incidence at 4 weeks postsurgery, stratified by VTE risk groups, and rated evidence certainty.Results:
Authors
Lauri I Lavikainen,Gordon H Guyatt,Ville J Sallinen,Paul J Karanicolas,Rachel J Couban,Tino Singh,Yung Lee,Jaana Elberkennou,Riikka Aaltonen,Kaisa Ahopelto,Ines Beilmann-Lehtonen,Marco H Blanker,Jovita L Cárdenas,Rufus Cartwright,Samantha Craigie,PJ Devereaux,Herney A Garcia-Perdomo,Fang Zhou Ge,Huda A Gomaa,Alex LE Halme,Jari Haukka,Päivi K Karjalainen,Tuomas P Kilpeläinen,Antti J Kivelä,Hanna Lampela,Anne K Mattila,Borna Tadayon Najafabadi,Taina P Nykänen,Sanjay Pandanaboyana,Negar Pourjamal,Chathura BB Ratnayake,Aleksi Raudasoja,Robin WM Vernooij,Philippe D Violette,Yuting Wang,Yingqi Xiao,Liang Yao,Kari AO Tikkinen,ROTBIGGS Investigators
Published Date
2024/2/1
Short-and long-term effects of imatinib in patients hospitalised for COVID-19 infection: A randomised controlled trial (preprint)
We report the short-and long-term results of the SOLIDARITY Finland on mortality and other patient-important outcomes in patients hospitalised for COVID-19. Between 08/2021 and 03/2023, we randomised 156 patients in 15 hospitals. In the imatinib group, 7.2% of patients had died at 30 days and 13.3% at 1 year and in the standard of care group 4.1% and 8.3%(adjusted HR at 30 days 1.09, 95% CI 0.23-5.07). In a meta-analysis of randomised trials of imatinib versus standard of care (n= 732), allocation to imatinib was associated with a mortality risk ratio of 0.73 (95% CI 0.32-1.63). At 1-year, self-reported recovery occurred in 79.0% in imatinib and in 88.3% in standard of care (RR 0.91, 95% CI 0.78-1.06). Of the 21 potential long COVID symptoms, patients often reported moderate or major bother from fatigue (24%), sleeping problems (19%) and memory difficulties (17%). We found no convincing difference between imatinib and standard of care groups in quality of life or symptom outcomes. The evidence raises serious doubts regarding the benefit of imatinib in reducing mortality, improving recovery and preventing potential long COVID symptoms when given to patients hospitalised for COVID-19.
Authors
Alex Halme,Sanna Laakkonen,Jarno Rutanen,Olli Nevalainen,Marjatta Sinisalo,Saana Horstia,Jussi Mustonen,Negar Pourjamal,Aija Vanhanen,Tuomas Rosberg,Andreas Renner,Markus Perola,Erja-Leena Paukkeri,Riitta-Liisa Patovirta,Seppo Parkkila,Juuso Paajanen,Taina Nykanen,Jarkko Mantyla,Marjukka Myllarniemi,Tiina Mattila,Maarit Leinonen,Alvar Kulmasu,Pauliina Kuutti,Ilari Kuitunen,Hanna-Riikka Kreivi,Tuomas Kilpelainen,Heikki Kauma,Ilkka Kalliala,Petrus Jarvinen,Riina Hankkio,Taina Hammaren,Thijs Feuth,Hanna Ansakorpi,Riikka Ala-Karvia,Gordon Guyatt,Kari Tikkinen
Published Date
2024
Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force on Practice …
BackgroundGuidance addressing atopic dermatitis (AD) management, last issued in 2012 by the American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force, requires updating as a result of new treatments and improved guideline and evidence synthesis methodology.ObjectiveTo produce evidence-based guidelines that support patients, clinicians, and other decision-makers in the optimal treatment of AD.MethodsA multidisciplinary guideline panel consisting of patients and caregivers, AD experts (dermatology and allergy/immunology), primary care practitioners (family medicine, pediatrics, internal medicine), and allied health professionals (psychology, pharmacy, nursing) convened, prioritized equity, diversity, and inclusiveness, and implemented management strategies to minimize influence of conflicts of interest. The Evidence in Allergy Group …
Authors
Derek K Chu,Lynda Schneider,Rachel Netahe Asiniwasis,Mark Boguniewicz,Anna De Benedetto,Kathy Ellison,Winfred T Frazier,Matthew Greenhawt,Joey Huynh,Elaine Kim,Jennifer LeBovidge,Mary Laura Lind,Peter Lio,Stephen A Martin,Monica O'Brien,Peck Y Ong,Jonathan I Silverberg,Jonathan M Spergel,Julie Wang,Kathryn E Wheeler,Gordon H Guyatt,Patient Groups,Korey Capozza,Wendy Smith Begolka,Alexandro WL Chu,Irene X Zhao,Lina Chen,Paul Oykhman,Layla Bakaa,The AAAAI,ACAAI Joint Task Force on Practice,David Golden,Marcus Shaker,Jonathan A Bernstein,Caroline C Horner,Jay Lieberman,David Stukus,Matthew A Rank,Anne Ellis,Elissa Abrams,Dennis Ledford,National Eczema Association
Journal
Annals of Allergy, Asthma & Immunology
Published Date
2024/3/1
Gefapixant for Chronic Cough—Reply
To the Editor Although sometimes considered the pinnacle of scientific evidence, meta-analyses can be problematic. Combining outcomes from heterogeneous trials performed in different settings or populations may give results directly applicable to few. Conclusions are also beholden to methodological design, often discordant from those of subsequent randomized clinical trials. 1 Such may be the case with the recently published dose-response meta-analysis of studies examining efficacy and tolerability of gefapixant for refractory or unexplained chronic cough. 2 Because gefapixant is the first novel efficacious therapy for refractory and unexplained chronic cough, its development involved changes in study design and participant inclusion criteria as well as drug formulation. 3 Four drug formulations were ultimately tested, with maximum bioavailability achieved for the formulation used in the phase 3 trials, such that …
Authors
Elena Kum,Gordon H Guyatt,Imran Satia
Journal
JAMA
Published Date
2024/2/13
Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials
Their stated aim is to summarise the “benefits and harms of weight-lowering drugs”, but the main findings and discussion focus on weight loss, without due consideration to the scarcity of evidence for benefits to health and wellbeing. For instance, quality of life and depression data are reported as low quality or insufficient, and there is no mention of the absence of long-term cardiovascular outcomes. A review on long-term effects of weight-reducing pharmacotherapy included only one trial with cardiovascular outcomes; it found no benefit.
Authors
Elizabeth Sturgiss,Lauren Ball,David Blane,Marita Hennessy,Fiona Quigley
Journal
The Lancet
Published Date
2022/6/4
Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives
IntroductionThe objective of this study was to create a definition of patient-important upper gastrointestinal bleeding during critical illness as an outcome for a randomized trial.DesignThis was a sequential mixed-methods qualitative-dominant multi-center study with an instrument-building aim. In semi-structured individual interviews or focus groups we elicited views from survivors of critical illness and family members of patients in the intensive care unit (ICU) regarding which features indicate important gastrointestinal bleeding. Quantitative demographic characteristics were collected. We analyzed qualitative data using inductive content analysis to develop a definition for patient-important upper gastrointestinal bleeding.SettingCanada and the United States.Participants51 ICU survivors and family members of ICU patients.ResultsParticipants considered gastrointestinal bleeding to be important if it resulted in death …
Authors
Meredith G Vanstone,Karla Krewulak,Shipra Taneja,Marilyn Swinton,Kirsten Fiest,Karen EA Burns,Sylvie Debigare,Joanna C Dionne,Gordon Guyatt,John C Marshall,John G Muscedere,Adam M Deane,Simon Finfer,John A Myburgh,Audrey Gouskos,Bram Rochwerg,Ian Ball,Tina Mele,Daniel J Niven,Shane W English,Madeleine Verhovsek,Deborah J Cook,Canadian Critical Care Trials Group
Journal
Journal of Critical Care
Published Date
2024/6/1
Factors Impacting Physician Prognostic Accuracy in Heart Failure Patients With Reduced Left Ventricular Ejection Fraction
BackgroundA recent study showed that the accuracy of heart failure (HF) cardiologists and family doctors to predict mortality in outpatients with HF proved suboptimal, performing less well than models.ObjectivesThe authors sought to evaluate patient and physician factors associated with physician accuracy.MethodsThe authors included outpatients with HF from 11 HF clinics. Family doctors and HF cardiologists estimated patient 1-year mortality. They calculated predicted mortality using the Seattle HF Model and followed patients for 1 year to record mortality (or urgent heart transplant or ventricular assist device implant as mortality-equivalent events). Using multivariable logistic regression, the authors evaluated associations among physician experience and confidence in estimates, duration of patient-physician relationship, patient-physician sex concordance, patient race, and predicted risk, with concordant results …
Authors
Ana C Alba,Tayler A Buchan,Sudipta Saha,Steve Fan,Stephanie Poon,Susanna Mak,Abdul Al-Hesayen,Mustafa Toma,Shelley Zieroth,Kim Anderson,Catherine Demers,Faizan Amin,Liane Porepa,Sharon Chih,Nadia Giannetti,Valeria Rac,Heather J Ross,Gordon H Guyatt
Journal
JACC: Heart Failure
Published Date
2024/3/27
The GRADE Working Group and CINeMA approaches provided inconsistent certainty of evidence ratings for a network meta-analysis of opioids for chronic noncancer pain
ObjectiveAssessment of the certainty of evidence (CoE) from network meta-analysis is critical to convey the strength of inferences for clinical decision-making. Both the GRADE Working Group (GWG) and the CINeMA framework have been designed to assess the CoE of treatment effects informed by network meta-analysis; however, the concordance of results is uncertain.Study design and settingWe assessed the CoE for treatment effects of individual opioids on pain relief and physical functioning from a network meta-analysis for chronic noncancer pain using the GWG approach and the CINeMA framework. Both approaches evaluate the CoE as high, moderate, low or very low. We quantified the number of discrepant CoE ratings between approaches, and the magnitude of the difference (i.e., 1-level, 2-levels, or 3-levels).ResultsAcross 105 comparisons among individual opioids for pain relief, the GWG and CINeMA …
Authors
Atefeh Noori,Behnam Sadeghirad,Lehana Thabane,Mohit Bhandari,Gordon H Guyatt,Jason W Busse
Journal
Journal of Clinical Epidemiology
Published Date
2024/2/8
Professor FAQs
What is Gordon Guyatt's h-index at McMaster University?
The h-index of Gordon Guyatt has been 166 since 2020 and 296 in total.
What are Gordon Guyatt's top articles?
The articles with the titles of
Systematic Reviews and Meta-analyses of the Procedure-specific Risks of Thrombosis and Bleeding in General Abdominal, Colorectal, Upper Gastrointestinal, and …
Short-and long-term effects of imatinib in patients hospitalised for COVID-19 infection: A randomised controlled trial (preprint)
Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force on Practice …
Gefapixant for Chronic Cough—Reply
Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials
Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives
Factors Impacting Physician Prognostic Accuracy in Heart Failure Patients With Reduced Left Ventricular Ejection Fraction
The GRADE Working Group and CINeMA approaches provided inconsistent certainty of evidence ratings for a network meta-analysis of opioids for chronic noncancer pain
...
are the top articles of Gordon Guyatt at McMaster University.
What are Gordon Guyatt's research interests?
The research interests of Gordon Guyatt are: Evidence-based medicine
What is Gordon Guyatt's total number of citations?
Gordon Guyatt has 412,618 citations in total.