Yoshihiro Kawaoka
University of Wisconsin-Madison
H-index: 169
North America-United States
Description
Yoshihiro Kawaoka, With an exceptional h-index of 169 and a recent h-index of 92 (since 2020), a distinguished researcher at University of Wisconsin-Madison, specializes in the field of Virology.
His recent articles reflect a diverse array of research interests and contributions to the field:
Seroprevalence of severe acute respiratory syndrome coronavirus 2 N antibodies between December 2021 and march 2023 in Japan
Successful management of persistent COVID-19 using combination antiviral therapy (nirmatrelvir/ritonavir and remdesivir) and intravenous immunoglobulin transfusion in an …
Characterization of a human H3N8 influenza virus
Tracing the origin of SARS-CoV-2 omicron-like spike sequences detected in an urban sewershed: a targeted, longitudinal surveillance study of a cryptic wastewater lineage
Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responses
Clinical Efficacy of Imdevimab/Casirivimab for Persistent Omicron SARS-CoV-2 Infection in Patients with Hematological Malignancies
Recombinant influenza viruses with stabilized na
Assessment of the antigenic evolution of a clade 6B. 1 human H1N1pdm influenza virus revealed differences between ferret and human convalescent sera
Professor Information
University | University of Wisconsin-Madison |
---|---|
Position | /University of Tokyo |
Citations(all) | 116947 |
Citations(since 2020) | 37250 |
Cited By | 90852 |
hIndex(all) | 169 |
hIndex(since 2020) | 92 |
i10Index(all) | 790 |
i10Index(since 2020) | 581 |
University Profile Page | University of Wisconsin-Madison |
Research & Interests List
Virology
Top articles of Yoshihiro Kawaoka
Seroprevalence of severe acute respiratory syndrome coronavirus 2 N antibodies between December 2021 and march 2023 in Japan
AIM:Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. To control the spread, a mass vaccination program is initiated. Antibody titer after vaccination can be a better marker to monitor immunological response.MATERIALS AND METHODS:The study was carried out at the Department of Microbiology, Narayan Medical College and Hospital, Jamuhar Sasaram, southwest Bihar, considering the sample size, type, and collection. First, antibody was tested before vaccination and second antibody value after 28 days of the first dose of COVID vaccine among the health-care workers and housekeeping staff.RESULTS:A total of 251 subjects were administered with vaccination (Covishield) to check the immunoglobulin g (IgG) responses. The concentration of the SARS-CoV-2 IgG antibody in female patients tended to be …
Authors
Mukesh Kumar,Richa Singh,Abhishek Kamendu,Amit K Singh,Jyoti Sangwan
Journal
Indian Journal of Health Sciences and Biomedical Research kleu
Published Date
2022/9/1
Successful management of persistent COVID-19 using combination antiviral therapy (nirmatrelvir/ritonavir and remdesivir) and intravenous immunoglobulin transfusion in an …
The management of persistent symptomatic coronavirus disease 2019 (COVID-19) infections in immunocompromised patients remains unclear. Here, we present the first case of successful antiviral therapy (nirmatrelvir/ritonavir and remdesivir) in combination with intravenous immunoglobulin (IVIg) in a patient who had received CD20 depleting therapy for follicular lymphoma and experienced recurrent COVID-19 relapses. After the patient received IVIg treatment, the viral load decreased without recurrence. Subsequently, it was found that the anti-spike antibody titer in the administered immunoglobulin was high at 9528.0 binding antibody units/mL. Our case highlights the potential of combination therapy with selective IVIg and antiviral drugs for relapsed immunocompromised COVID-19 patients who have received CD20 depleting therapy.
Authors
Taketomo Maruki,Hidetoshi Nomoto,Noriko Iwamoto,Kei Yamamoto,Masami Kurokawa,Kiyoko Iwatsuki-Horimoto,Seiya Yamayoshi,Yutaka Suzuki,Yoshihiro Kawaoka,Norio Ohmagari
Journal
Journal of Infection and Chemotherapy
Published Date
2024/1/17
Characterization of a human H3N8 influenza virus
BackgroundIn 2022 and 2023, novel reassortant H3N8 influenza viruses infected three people, marking the first human infections with viruses of this subtype.MethodsHere, we generated one of these viruses (A/Henan/4-10CNIC/2022; hereafter called A/Henan/2022 virus) by using reverse genetics and characterized it.FindingsIn intranasally infected mice, reverse genetics-generated A/Henan/2022 virus caused weight loss in all five animals (one of which had to be euthanized) and replicated efficiently in the respiratory tract. Intranasal infection of ferrets resulted in minor weight loss and moderate fever but no mortality. Reverse genetics-generated A/Henan/2022 virus replicated efficiently in the upper respiratory tract of ferrets but was not detected in the lungs. Virus transmission via respiratory droplets occurred in one of four pairs of ferrets. Deep-sequencing of nasal swab samples from inoculated and exposed …
Authors
Chunyang Gu,Shufang Fan,Randall Dahn,Lavanya Babujee,Shiho Chiba,Lizheng Guan,Tadashi Maemura,David Pattinson,Gabriele Neumann,Yoshihiro Kawaoka
Journal
EBioMedicine
Published Date
2024/3/1
Tracing the origin of SARS-CoV-2 omicron-like spike sequences detected in an urban sewershed: a targeted, longitudinal surveillance study of a cryptic wastewater lineage
Importance The origin of highly divergent" cryptic" SARS-CoV-2 Spike sequences, which appear in wastewater but not clinical samples, is unknown. These wastewater sequences have harbored many of the same variants that later emerged in Omicron. If these enigmatic sequences are human-derived and transmissible, they could both be a source of future variants and a valuable tool for forecasting sequences that should be incorporated into vaccines and therapeutics.Objective:To determine whether enigmatic SARS-CoV-2 lineages detected in wastewater have a human or non-human (ie, animal) source.Design:On January 11, 2022, an unusual Spike sequence was detected in municipal wastewater from a metropolitan area. Over the next four months, more focused wastewater sampling resolved the source of this variant.Setting:This study was performed in Wisconsin, United States, which has a comprehensive program for detecting SARS-CoV-2 in wastewater.Participants:Composite wastewater samples were used for this study; therefore, no individuals participated. Main Outcome (s) and Measure (s) The primary outcome was to determine the host (s) responsible for shedding this variant in wastewater. Both human and non-human hosts were plausible candidates at the study's outset.Results:The presence of the cryptic virus was narrowed from a municipal wastewater sample (catchment area> 100,000 people) to an indoor wastewater sample from a single facility (catchment area~ 30 people), indicating the human origin of this virus. Extraordinarily high concentrations of viral RNA (~ 520,000,000 genome copies/L and~ 1,600,000,000 …
Authors
Martin M Shafer,Devon A Gregory,Max J Bobholz,Adelaide Roguet,Luis A Haddock Soto,Clayton Rushford,William C Vuyk,Kayley H Janssen,Hunter J Ries,Hannah E Pilch,Paige A Mullen,Rebecca B Fahney,Wanting Wei,Matthew Lambert,Jeff Wenzel,Peter Halfmann,Yoshihiro Kawaoka,Nancy A Wilson,Thomas C Friedrich,Ian W Pray,Ryan Westergaard,David H O'Connor,Marc Johnson
Published Date
2022
Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responses
BackgroundWorld Health Organisation (WHO) and USA Centers for Disease Control and Prevention (U.S. CDC) recommendations now allow simultaneous administration of COVID-19 and other vaccines. We compared antibody responses after coadministration of influenza and bivalent COVID-19 vaccines in the same (ipsilateral) arm vs. different (contralateral) arms.MethodsPre- and post-vaccination serum samples from individuals in the Prospective Assessment of COVID-19 in a Community (PACC) cohort were used to conduct haemaglutination inhibition (HI) assays with the viruses in the 2022–2023 seasonal influenza vaccine and focus reduction neutralisation tests (FRNT) using a BA.5 SARS-CoV-2 virus. The effect of ipsilateral vs. contralateral vaccination on immune responses was inferred in a model that accounted for higher variance in vaccine responses at lower pre-vaccination titers.FindingsIpsilateral …
Authors
David Pattinson,Peter Jester,Chunyang Gu,Lizheng Guan,Tammy Armbrust,Joshua G Petrie,Jennifer P King,Huong Q Nguyen,Edward A Belongia,Peter Halfmann,Gabriele Neumann,Yoshihiro Kawaoka
Journal
Ebiomedicine
Published Date
2024/5/1
Clinical Efficacy of Imdevimab/Casirivimab for Persistent Omicron SARS-CoV-2 Infection in Patients with Hematological Malignancies
Objective Prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been reported in immunocompromised patients, as they poorly develop antibodies against SARS-CoV-2. We conducted a clinical trial to determine the efficacy of Imdevimab/Casirivimab (Imde/Casiri), an anti-viral monoclonal antibody (mAb), for prolonged infection at our institution.Methods Nine patients with hematological malignancies (six with malignant lymphoma and three with multiple myeloma) in our institution presented with coronavirus disease 2019 caused by SARS-CoV-2 omicron variants (one, five, and one with BA. 2, BA. 5, and BF. 7, respectively; two undetermined). Although not all nine patients developed severe disease, viral mRNA was detected in all patients after treatment with remdesivir or molnupiravir. Imde/casiri was infused 11-49 days after the disease onset.Results Within seven days of infusion, viral RNA was undetectable in five of the nine cases. Because all seven viruses isolated from patients whose viral RNA became undetectable showed low or no sensitivity to this monoclonal antibody cocktail, the disappearance of viral RNA in these cases may not be attributable to the antibody cocktail.Conclusion It may be worth considering the use of monoclonal antibodies that show some activity against these virus variants to treat persistent SARS-CoV-2 infection in immunocompromised patients.
Authors
Masao Hagihara,Hiroyoshi Hayashi,Shiori Nakashima,Yui Imai,Hirofumi Nakano,Tomoyuki Uchida,Morihiro Inoue,Yuko Sakai-Tagawa,Mutsumi Ito,Seiya Yamayoshi,Kiyoko Iwatsuki-Horimoto,Yutaka Suzuki,Yoshihiro Kawaoka
Journal
Internal Medicine
Published Date
2024
Recombinant influenza viruses with stabilized na
Modified influenza virus neuraminidases are described herein that have stabilized NA tetramers which may improve vaccine production efficiency, thus improving the yield of vaccine viruses.
Published Date
2024/1/11
Assessment of the antigenic evolution of a clade 6B. 1 human H1N1pdm influenza virus revealed differences between ferret and human convalescent sera
BackgroundInfluenza viruses continually acquire mutations in the antigenic epitopes of their major viral antigen, the surface glycoprotein haemagglutinin (HA), allowing evasion from immunity in humans induced upon prior influenza virus infections or vaccinations. Consequently, the influenza strains used for vaccine production must be updated frequently.MethodsTo better understand the antigenic evolution of influenza viruses, we introduced random mutations into the HA head region (where the immunodominant epitopes are located) of a pandemic H1N1 (H1N1pdm) virus from 2015 and incubated it with various human sera collected in 2015–2016. Mutants not neutralized by the human sera were sequenced and further characterized for their haemagglutination inhibition (HI) titers with human sera and with ferret sera raised to H1N1pdm viruses from 2009 to 2015.FindingsThe largest antigenic changes were …
Authors
Shufang Fan,Huihui Kong,Lavanya Babujee,Robert Presler,Peter Jester,David Burke,David Pattinson,Ian Barr,Derek Smith,Gabriele Neumann,Yoshihiro Kawaoka
Journal
Ebiomedicine
Published Date
2024/3/1
Professor FAQs
What is Yoshihiro Kawaoka's h-index at University of Wisconsin-Madison?
The h-index of Yoshihiro Kawaoka has been 92 since 2020 and 169 in total.
What are Yoshihiro Kawaoka's top articles?
The articles with the titles of
Seroprevalence of severe acute respiratory syndrome coronavirus 2 N antibodies between December 2021 and march 2023 in Japan
Successful management of persistent COVID-19 using combination antiviral therapy (nirmatrelvir/ritonavir and remdesivir) and intravenous immunoglobulin transfusion in an …
Characterization of a human H3N8 influenza virus
Tracing the origin of SARS-CoV-2 omicron-like spike sequences detected in an urban sewershed: a targeted, longitudinal surveillance study of a cryptic wastewater lineage
Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responses
Clinical Efficacy of Imdevimab/Casirivimab for Persistent Omicron SARS-CoV-2 Infection in Patients with Hematological Malignancies
Recombinant influenza viruses with stabilized na
Assessment of the antigenic evolution of a clade 6B. 1 human H1N1pdm influenza virus revealed differences between ferret and human convalescent sera
...
are the top articles of Yoshihiro Kawaoka at University of Wisconsin-Madison.
What are Yoshihiro Kawaoka's research interests?
The research interests of Yoshihiro Kawaoka are: Virology
What is Yoshihiro Kawaoka's total number of citations?
Yoshihiro Kawaoka has 116,947 citations in total.