William A. Banks
University of Washington
H-index: 132
North America-United States
Description
William A. Banks, With an exceptional h-index of 132 and a recent h-index of 69 (since 2020), a distinguished researcher at University of Washington, specializes in the field of blood-brain barrier.
His recent articles reflect a diverse array of research interests and contributions to the field:
Insulin and the blood–brain barrier
New approaches for understanding the potential role of microbes in Alzheimer's disease
Cellular senescence and the blood–brain barrier: Implications for aging and age-related diseases
Timing matters: Sex differences in inflammatory and behavioral outcomes following repetitive blast mild traumatic brain injury
Effects of Ozone on Sickness and Depressive-like Behavioral and Biochemical Phenotypes and Their Regulation by Serum Amyloid A in Mice
Regulation of CCL2 transport across the blood-brain barrier
Central nervous system insulin signaling can influence the rate of insulin influx into brain
Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer’s disease
Professor Information
University | University of Washington |
---|---|
Position | Veterans Affairs |
Citations(all) | 62722 |
Citations(since 2020) | 20452 |
Cited By | 50692 |
hIndex(all) | 132 |
hIndex(since 2020) | 69 |
i10Index(all) | 506 |
i10Index(since 2020) | 314 |
University Profile Page | University of Washington |
Research & Interests List
blood-brain barrier
Top articles of William A. Banks
Insulin and the blood–brain barrier
The blood–brain barrier (BBB) predominantly regulates insulin transport into and levels within the brain. The BBB is also an important site of insulin binding and mediator of insulin receptor (INSR) signaling. The insulin transporter is separate from the INSR, highlighting the important, unique role of each protein in this structure. After a brief introduction on the structure of insulin and the INSR, we discuss the importance of insulin interactions at the BBB, the properties of the insulin transporter and the role of the BBB insulin transporter in various physiological conditions. We go on to further describe insulin BBB signaling and the impact not only within brain endothelial cells but also the cascade into other cell types within the brain. We close with future considerations to advance our knowledge about the importance of insulin at the BBB.
Authors
Elizabeth M Rhea,William A Banks
Published Date
2024/2/22
New approaches for understanding the potential role of microbes in Alzheimer's disease
Alzheimer's disease (AD) involves a complex pathological process that evolves over years, and its etiology is understood as a classic example of gene-environment interaction. The notion that exposure to microbial organisms may play some role in AD pathology has been proposed and debated for decades. New evidence from model organisms and -omic studies, as well as epidemiological data from the recent COVID-19 pandemic and widespread use of vaccines, offers new insights into the “germ hypothesis” of AD. To review new evidence and identify key research questions, the Duke/University of North Carolina (Duke/UNC) Alzheimer's Disease Research Center hosted a virtual symposium and workshop: “New Approaches for Understanding the Potential Role of Microbes in Alzheimer's disease.” Discussion centered around the antimicrobial protection hypothesis of amyloid accumulation, and other …
Authors
Heather E Whitson,William A Banks,Monica M Diaz,Bess Frost,Manolis Kellis,Richard Lathe,Kenneth E Schmader,Serena S Spudich,Rudolph Tanzi,Gwenn Garden
Published Date
2024/2/21
Cellular senescence and the blood–brain barrier: Implications for aging and age-related diseases
The blood–brain barrier (BBB) is a critical physiochemical interface that regulates communication between the brain and blood. It is comprised of brain endothelial cells which regulate the BBB’s barrier and interface properties and is surrounded by supportive brain cell types including pericytes and astrocytes. Recent reports have suggested that the BBB undergoes dysfunction during normative aging and in disease. In this review, we consider the effect of cellular senescence, one of the nine hallmarks of aging, on the BBB. We first characterize known normative age–related changes at the BBB, and then evaluate changes in neurodegenerative diseases, with an emphasis on if/how cellular senescence is influencing these changes. We then discuss what insight has been gained from in vitro and in vivo studies of cellular senescence at the BBB. Finally, we evaluate mechanisms by which cellular senescence in …
Authors
Rachel C Knopp,Michelle A Erickson,Elizabeth M Rhea,May J Reed,William A Banks
Published Date
2023/3
Timing matters: Sex differences in inflammatory and behavioral outcomes following repetitive blast mild traumatic brain injury
BackgroundRepetitive blast-related mild traumatic brain injury (mTBI) caused by exposure to high explosives is increasingly common among warfighters as well as civilians. While women have been serving in military positions with increased risk of blast exposure since 2016, there are few published reports examining sex as a biological variable in models of blast mTBI, greatly limiting diagnosis and treatment capabilities. As such, here we examined outcomes of repetitive blast trauma in female and male mice in relation to potential behavioral, inflammatory, microbiome, and vascular dysfunction at multiple timepoints.MethodsIn this study we utilized a well-established blast overpressure model to induce repetitive (3x) blast-mTBI in both female and male mice. Acutely following repetitive exposure, we measured serum and brain cytokine levels, blood–brain barrier (BBB) disruption, fecal microbial abundance, and …
Authors
Britahny M Baskin,Aric F Logsdon,Suhjung Janet Lee,Brian D Foresi,Elaine Peskind,William A Banks,David G Cook,Abigail G Schindler
Journal
Brain, behavior, and immunity
Published Date
2023/5/1
Effects of Ozone on Sickness and Depressive-like Behavioral and Biochemical Phenotypes and Their Regulation by Serum Amyloid A in Mice
Ozone (O3) is an air pollutant which primarily damages the lungs, but growing evidence supports that O3 exposure can also affect the brain. Serum amyloid A (SAA) and kynurenine have been identified as circulating factors that are upregulated by O3, and both can contribute to depressive-like behaviors in mice. However, little is known about the relations of O3 exposure to sickness and depressive-like behaviors in experimental settings. In this study, we evaluated O3 dose-, time- and sex-dependent changes in circulating SAA in context of pulmonary inflammation and damage, sickness and depressive-like behavioral changes, and systemic changes in kynurenine and indoleamine 2,3-dioxygenase (IDO), an enzyme that regulates kynurenine production and contributes to inflammation-induced depressive-like behaviors. Our results in Balb/c and CD-1 mice showed that 3ppm O3, but not 2 or 1ppm O3, caused elevations in serum SAA and pulmonary neutrophils, and these responses resolved by 48 hours. Sickness and depressive-like behaviors were observed at all O3 doses (1-3ppm), although the detection of certain behavioral changes varied by dose. We also found that Ido1 mRNA expression was increased in the brain and spleen 24 hours after 3ppm O3, and that kynurenine was increased in blood. Together, these findings indicate that acute O3 exposure induces transient symptoms of sickness and depressive-like behaviors which may occur in the presence or absence of overt pulmonary neutrophilia and systemic increases of SAA. We also present evidence that the IDO/kynurenine pathway is upregulated systemically following an acute …
Authors
Kristen K Baumann,Wei-Shan Sandy Liang,Daniel V Quaranta,Miranda L Wilson,Helina S Asrat,Jarl A Thysell,Angelo V Sarchi,William A Banks,Michelle A Erickson
Journal
bioRxiv
Published Date
2021/1/1
Regulation of CCL2 transport across the blood-brain barrier
Background: The vascular blood-brain barrier (BBB) is an important neuroimmune interface of the brain comprised primarily of endothelial cells. Our prior work has shown that circulating chemokines including CCL2 can cross the intact BBB. Herein, we investigate mechanisms by which CCL2 crosses the BBB under baseline and inflammatory conditions.Methods: The BBB transport of mouse 125 I-mCCL2 was measured in male and female CD-1 mice using multiple-time regression analysis or in situ brain perfusion methods, n= 7–15/group. Rates of brain uptake were calculated using linear regression, and slopes and intercepts compared using ANCOVA. In studies that used single time points (n= 7–10 mice per group), t-test or ANOVA compared group means. Transport of human 125 I-hCCL2 was measured using an in vitro BBB model. Investigations of heparan sulfate-regulated transport were done by perfusing …
Authors
Takashi Fujimoto,Lindsey Williams,Daniel Quaranta,Riley Weaver,William Banks,Michelle Erickson
Journal
Brain, Behavior, and Immunity
Published Date
2023/11/1
Central nervous system insulin signaling can influence the rate of insulin influx into brain
BackgroundInsulin transport across the blood-brain barrier (BBB) is a highly regulated, saturable process, known to be affected by many peripheral substrates including insulin itself and triglycerides. This is in contrast to insulin leakage into peripheral tissues. Whether the central nervous system (CNS) can control the rate of insulin uptake by brain remains to be determined. Insulin BBB interactions are impaired in Alzheimer’s disease (AD) and CNS insulin resistance is widely prevalent in AD. Therefore, if CNS insulin controls the rate of insulin transport across the BBB, then the defective transport of insulin seen in AD could be one manifestation of the resistance to CNS insulin observed in AD.MethodsWe investigated whether enhancing CNS insulin levels or induction of CNS insulin resistance using an inhibitor of the insulin receptor altered the blood-to-brain transport of radioactively labeled insulin in young …
Authors
Van Nguyen,Peter Thomas,Sarah Pemberton,Alice Babin,Cassidy Noonan,Riley Weaver,William A Banks,Elizabeth M Rhea
Journal
Fluids and Barriers of the CNS
Published Date
2023/4/19
Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer’s disease
COVID-19 and especially Long COVID are associated with severe CNS symptoms and may place persons at risk to develop long-term cognitive impairments. Here, we show that two non-infective models of SARS-CoV-2 can cross the blood–brain barrier (BBB) and induce neuroinflammation, a major mechanism underpinning CNS and cognitive impairments, even in the absence of productive infection. The viral models cross the BBB by the mechanism of adsorptive transcytosis with the sugar N-acetylglucosamine being key. The delta and omicron variants cross the BB B faster than the other variants of concern, with peripheral tissue uptake rates also differing for the variants. Neuroinflammation induced by icv injection of S1 protein was greatly enhanced in young and especially in aged SAMP8 mice, a model of Alzheimer’s disease, whereas sex and obesity had little effect.
Authors
Michelle A Erickson,Aric F Logsdon,Elizabeth M Rhea,Kim M Hansen,Sarah J Holden,William A Banks,Jessica L Smith,Cody German,Susan A Farr,John E Morley,Riley R Weaver,Alec J Hirsch,Andrej Kovac,Eva Kontsekova,Kristen K Baumann,Mohamed A Omer,Jacob Raber
Journal
Brain, behavior, and immunity
Published Date
2023/3/1
Professor FAQs
What is William A. Banks's h-index at University of Washington?
The h-index of William A. Banks has been 69 since 2020 and 132 in total.
What are William A. Banks's top articles?
The articles with the titles of
Insulin and the blood–brain barrier
New approaches for understanding the potential role of microbes in Alzheimer's disease
Cellular senescence and the blood–brain barrier: Implications for aging and age-related diseases
Timing matters: Sex differences in inflammatory and behavioral outcomes following repetitive blast mild traumatic brain injury
Effects of Ozone on Sickness and Depressive-like Behavioral and Biochemical Phenotypes and Their Regulation by Serum Amyloid A in Mice
Regulation of CCL2 transport across the blood-brain barrier
Central nervous system insulin signaling can influence the rate of insulin influx into brain
Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer’s disease
...
are the top articles of William A. Banks at University of Washington.
What are William A. Banks's research interests?
The research interests of William A. Banks are: blood-brain barrier
What is William A. Banks's total number of citations?
William A. Banks has 62,722 citations in total.