Thomas C Quinn, MD, MSc
Johns Hopkins University
H-index: 162
North America-United States
Description
Thomas C Quinn, MD, MSc, With an exceptional h-index of 162 and a recent h-index of 57 (since 2020), a distinguished researcher at Johns Hopkins University, specializes in the field of Infectious Diseases.
His recent articles reflect a diverse array of research interests and contributions to the field:
Association of Oral Microbiome With Oral Human Papillomavirus Infection: A Population Study of the National Health and Nutrition Examination Survey, 2009–2012
Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen
Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage
Incidence of Health Facility Switching and Associations With Human Immunodeficiency Virus Viral Rebound Among Persons on Antiretroviral Therapy in Uganda: A Population-based Study
Increasing intra-and inter-subtype HIV diversity despite declining HIV incidence in Uganda
Longitudinal patterns in indeterminate HIV rapid antibody test results: a population-based, prospective cohort study
Demographics of sources of HIV-1 transmission in Zambia: a molecular epidemiology analysis in the HPTN 071 PopART study
Trends in HPV Vaccination Before Age 13 Years in the US National Immunization Survey–Teen
Professor Information
University | Johns Hopkins University |
---|---|
Position | NIAID NIH and |
Citations(all) | 107591 |
Citations(since 2020) | 20059 |
Cited By | 127039 |
hIndex(all) | 162 |
hIndex(since 2020) | 57 |
i10Index(all) | 828 |
i10Index(since 2020) | 366 |
University Profile Page | Johns Hopkins University |
Research & Interests List
Infectious Diseases
Top articles of Thomas C Quinn, MD, MSc
Association of Oral Microbiome With Oral Human Papillomavirus Infection: A Population Study of the National Health and Nutrition Examination Survey, 2009–2012
Background Oral human papillomavirus (HPV) infection and the oral microbiome are associated with oropharyngeal cancer. However, population-based data on the association of oral microbiome with oral HPV infection are limited. Method A cross-sectional analysis of 5496 20–59-year-old participants in the 2009–2012 National Health and Nutrition Examination Survey was performed. Associations with oral HPV infection were assessed using multivariable logistic regression for oral microbiome α-diversity (within-sample diversity), and using principal coordinate analysis and permutational multivariate analysis of variance for β-diversity (between-sample heterogeneity). Results Overall, for α-diversity, a lower number of observed amplicon sequence variants (adjusted odds ratio [aOR] = 0.996; 95% confidence interval [CI] = .992–.999) and reduced Faith's …
Authors
Xinyi Feng,Eshan U Patel,Jodie L White,Shilan Li,Xianming Zhu,Ni Zhao,Jianxin Shi,Daniel E Park,Cindy M Liu,Rupert Kaul,Jessica L Prodger,Thomas C Quinn,M Kate Grabowski,Aaron AR Tobian
Journal
The Journal of Infectious Diseases
Published Date
2024/1/5
Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen
BackgroundThe principal barrier to an HIV cure is the presence of the latent viral reservoir (LVR), which has been understudied in African populations. From 2018 to 2019, Uganda instituted a nationwide rollout of ART consisting of Dolutegravir (DTG) with two NRTI, which replaced the previous regimen of one NNRTI and the same two NRTI.MethodsChanges in the inducible replication-competent LVR (RC-LVR) of ART-suppressed Ugandans with HIV (n = 88) from 2015 to 2020 were examined using the quantitative viral outgrowth assay. Outgrowth viruses were examined for viral evolution. Changes in the RC-LVR were analyzed using three versions of a Bayesian model that estimated the decay rate over time as a single, linear rate (model A), or allowing for a change at time of DTG initiation (model B&C).FindingsModel A estimated the slope of RC-LVR change as a non-significant positive increase, which was due …
Authors
Roux-Cil Ferreira,Steven J Reynolds,Adam A Capoferri,Owen R Baker,Erin E Brown,Ethan Klock,Jernelle Miller,Jun Lai,Sharada Saraf,Charles Kirby,Briana Lynch,Jada Hackman,Sarah N Gowanlock,Stephen Tomusange,Samiri Jamiru,Aggrey Anok,Taddeo Kityamuweesi,Paul Buule,Daniel Bruno,Craig Martens,Rebecca Rose,Susanna L Lamers,Ronald M Galiwango,Art FY Poon,Thomas C Quinn,Jessica L Prodger,Andrew D Redd
Journal
EBioMedicine
Published Date
2024/4/1
Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage
Introduction To prioritize and tailor interventions for ending AIDS by 2030 in Africa, it is important to characterize the population groups in which HIV viraemia is concentrating. Methods We analysed HIV testing and viral load data collected between 2013-2019 from the open, population-based Rakai Community Cohort Study (RCCS) in Uganda, to estimate HIV seroprevalence and population viral suppression over time by gender, one-year age bands and residence in inland and fishing communities. All estimates were standardized to the underlying source population using census data. We then assessed 95-95-95 targets in their ability to identify the populations in which viraemia concentrates. Results Following the implementation of Universal Test and Treat, the proportion of individuals with viraemia decreased from 4.9% (4.6%-5.3%) in 2013 to 1.9% (1.7%-2.2%) in 2019 in inland communities and from 19.1% (18.0%-20.4%) in 2013 to 4.7% (4.0%-5.5%) in 2019 in fishing communities. Viraemia did not concentrate in the age and gender groups furthest from achieving 95-95-95 targets. Instead, in both inland and fishing communities, women aged 25-29 and men aged 30-34 were the 5-year age groups that contributed most to population-level viraemia in 2019, despite these groups being close to or had already achieved 95-95-95 targets. Conclusions The 95-95-95 targets provide a useful benchmark for monitoring progress towards HIV epidemic control, but do not contextualize underlying population structures and so may direct interventions towards groups that represent a marginal fraction of the population with viraemia.
Authors
Andrea Brizzi,Joseph Kagaayi,Robert Ssekubugu,Lucie Abeler-Dorner,Alexandra Blenkinsop,David Bonsall,Larry W Chang,Christophe Fraser,Ronald Galiwango,Godfrey Kigozi,Imogen Kyle,Melodie Monod,Gertrude Nakigozi,Fred Nalugoda,Joseph G Rosen,Oliver Laeyndecker,Thomas Quinn,Kate Graboswki,Steven Reynolds,Oliver Ratmann,Rakai Health Sciences Program
Journal
medRxiv
Published Date
2024
Incidence of Health Facility Switching and Associations With Human Immunodeficiency Virus Viral Rebound Among Persons on Antiretroviral Therapy in Uganda: A Population-based Study
Background A substantial proportion of persons on antiretroviral therapy (ART) considered lost to follow-up have actually transferred their human immunodeficiency virus (HIV) care to other facilities. However, the relationship between facility switching and virologic outcomes, including viral rebound, is poorly understood. Methods We used data from 40 communities (2015–2020) in the Rakai Community Cohort Study to estimate incidence of facility switching and viral rebound. Persons aged 15–49 years living with serologically confirmed HIV who self-reported ART use and contributed ≥1 follow-up visit were included. Facility switching and virologic outcomes were assessed between 2 consecutive study visits (ie, index and follow-up visits, interval of approximately 18 months). Those who reported different HIV treatment facilities between index and follow-up study visits were …
Authors
Joseph G Rosen,Anthony Ndyanabo,Hadijja Nakawooya,Ronald M Galiwango,Robert Ssekubugu,Joseph Ssekasanvu,Seungwon Kim,Katherine B Rucinski,Gertrude Nakigozi,Fred Nalugoda,Godfrey Kigozi,Thomas C Quinn,Larry W Chang,Caitlin E Kennedy,Steven J Reynolds,Joseph Kagaayi,M Kate Grabowski
Journal
Clinical Infectious Diseases
Published Date
2024/3/7
Increasing intra-and inter-subtype HIV diversity despite declining HIV incidence in Uganda
HIV incidence has been declining in Africa with scale-up of HIV interventions. However, there is limited data on HIV evolutionary trends in African populations with waning epidemics. We evaluated changes in HIV viral diversity and genetic divergence in southern Uganda over a twenty-five-year period spanning the introduction and scale-up of HIV prevention and treatment programs using HIV sequence and survey data from the Rakai Community Cohort Study, an open longitudinal population-based HIV surveillance cohort. Gag (p24) and env (gp41) HIV data were generated from persons living with HIV (PLHIV) in 31 inland semi-urban trading and agrarian communities (1994 to 2018) and four hyperendemic Lake Victoria fishing communities (2011 to 2018) under continuous surveillance. HIV subtype was assigned using the Recombination Identification Program with phylogenetic confirmation. Inter-subtype diversity was estimated using the Shannon diversity index and intra-subtype diversity with the nucleotide diversity and pairwise TN93 genetic distance. Genetic divergence was measured using root-to-tip distance and pairwise TN93 genetic distance analyses. Evolutionary dynamics were assessed among demographic and behavioral sub-groups, including by migration status. 9,931 HIV sequences were available from 4,999 PLHIV, including 3,060 and 1,939 persons residing in inland and fishing communities, respectively. In inland communities, subtype A1 viruses proportionately increased from 14.3% in 1995 to 25.9% in 2017 (p<0.001), while those of subtype D declined from 73.2% in 1995 to 28.2% in 2017 (p<0.001). The proportion of …
Authors
Seungwon Kim,Godfrey Kigozi,Michael A Martin,Ronald M Galiwango,Thomas C Quinn,Andrew D Redd,Robert Ssekubugu,David G Bonsall,Deogratius Ssemwanga,Andrew Rambaut,Joshua T Herbeck,Steven J Reynolds,Brian Foley,Lucie Abeler-Dorner,Christophe Fraser,Oliver Ratmann,Joseph Kagaayi,Oliver Laeyendecker,Mary Kate Grabowski
Journal
medRxiv
Published Date
2024
Longitudinal patterns in indeterminate HIV rapid antibody test results: a population-based, prospective cohort study
Rapid HIV tests are critical to HIV surveillance and universal testing and treatment programs. We assessed longitudinal patterns in indeterminate HIV rapid test results in an African population-based cohort. Prospective HIV rapid antibody test results, defined by two parallel rapid tests, among participants aged 15–49 years from three survey rounds of the Rakai Community Cohort Study, Uganda, from 2013 to 2018, were assessed. An indeterminate result was defined as any weak positive result or when one test was negative and the other was positive. A total of 31,405 participants contributed 54,459 person-visits, with 15,713 participants contributing multiple visits and 7,351 participants contributing 3 visits. The prevalence of indeterminate results was 2.7% (1,490/54,469). Of the participants with multiple visits who initially tested indeterminate (n = 591), 40.4% were negative, 18.6% were positive, and 41.0% were …
Authors
Joanne H Hunt,George Mwinnyaa,Eshan U Patel,M Kate Grabowski,Joseph Kagaayi,Ronald H Gray,Joseph Ssekasanvu,Maria J Wawer,Godfrey Kigozi,Larry W Chang,Sarah Kalibbala,Margaret Nakalanzi,Anthony Ndyanabo,Thomas C Quinn,David Serwadda,Steven J Reynolds,Ronald M Galiwango,Oliver Laeyendecker
Journal
Microbiology Spectrum
Published Date
2024/2/6
Demographics of sources of HIV-1 transmission in Zambia: a molecular epidemiology analysis in the HPTN 071 PopART study
BackgroundIn the last decade, universally available antiretroviral therapy (ART) has led to greatly improved health and survival of people living with HIV in sub-Saharan Africa, but new infections continue to appear. The design of effective prevention strategies requires the demographic characterisation of individuals acting as sources of infection, which is the aim of this study.MethodsBetween 2014 and 2018, the HPTN 071 PopART study was conducted to quantify the public health benefits of ART. Viral samples from 7124 study participants in Zambia were deep-sequenced as part of HPTN 071-02 PopART Phylogenetics, an ancillary study. We used these sequences to identify likely transmission pairs. After demographic weighting of the recipients in these pairs to match the overall HIV-positive population, we analysed the demographic characteristics of the sources to better understand transmission in the general …
Authors
Matthew Hall,Tanya Golubchik,David Bonsall,Lucie Abeler-Dörner,Mohammed Limbada,Barry Kosloff,Ab Schaap,Mariateresa de Cesare,George MacIntyre-Cockett,Newton Otecko,William Probert,Oliver Ratmann,Ana Bulas Cruz,Estelle Piwowar-Manning,David N Burns,Myron S Cohen,Deborah J Donnell,Susan H Eshleman,Musonda Simwinga,Sarah Fidler,Richard Hayes,Helen Ayles,Christophe Fraser,Yaw Agyei,Nulda Beyers,Peter Bock,Virginia Bond,Justin Bwalya,Anne Cori,Anneen Deventer,Rory Dunbar,Wafaa El-Sadr,Lynda Emel,Sian Floyd,Sam Griffith,James Hargreaves,Katharina Hauck,Tanette Headen,Graeme Hoddinott,Anelet James,Karen Jennings,Sarah Kanema,James Kruger,Ramya Kumar,David Macleod,Nozizwe Makola,Nomtha Mandla,Eric Miller,Ayana Moore,Lawrence Mwenge,Heather Noble,Mwelwa Phiri,Michael Pickles,Kalpana Sabapathy,Ephraim Sakala,Rafael Sauter,Kwame Shanaube,Andrew Silumesi,Nirupama Sista,Tim Skalland,Peter Smith,Ranjeeta Thomas,Sten Vermund,Rhonda White,Ethan Wilson,Blia Yang,Krista Yuhas,Rory Bowden,Vincent Calvez,Max Essex,Kate Grabowski,Ravindra Gupta,Joshua Herbeck,Joseph Kagaayi,Pontiano Kaleebu,Jairam Lingappa,Sikhulile Moyo,Vladimir Novitsky,Thumbi Ndung’u,Deenan Pillay,Thomas Quinn,Andrew Rambaut,Janet Seeley,Deogratius Ssemwanga,Frank Tanser,Maria Wawer
Journal
The Lancet Microbe
Published Date
2024/1/1
Trends in HPV Vaccination Before Age 13 Years in the US National Immunization Survey–Teen
Methods| The National Immunization Survey (NIS)–Teen is a cross-sectional survey of parents and guardians of adolescents aged 13 to 17 years (eMethods in Supplement 1). 3 We examined percentages of these adolescents who initiated HPV vaccination and completed the series before age 13 years as separate outcomes and examined sex-specific trends. Analyses were then restricted to the last 4 survey years (2018-2021) given changes in survey procedures in 2018 and to ensure all participants were eligible to have been recommended HPV vaccination at age 11 to 12 years. We estimated annual percent change and prevalence difference (PD) in each outcome from 2018 to 2021, modeling survey year as a continuous and categorical variable in separate binomial regression models. Subgroup analyses were stratified by age at interview. Survey-weighted analyses were conducted in Stata/IC, version 15 …
Authors
Jodie L White,M Kate Grabowski,Thomas C Quinn,Aaron AR Tobian,Eshan U Patel
Journal
JAMA pediatrics
Published Date
2024/2/1
Professor FAQs
What is Thomas C Quinn, MD, MSc's h-index at Johns Hopkins University?
The h-index of Thomas C Quinn, MD, MSc has been 57 since 2020 and 162 in total.
What are Thomas C Quinn, MD, MSc's top articles?
The articles with the titles of
Association of Oral Microbiome With Oral Human Papillomavirus Infection: A Population Study of the National Health and Nutrition Examination Survey, 2009–2012
Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen
Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage
Incidence of Health Facility Switching and Associations With Human Immunodeficiency Virus Viral Rebound Among Persons on Antiretroviral Therapy in Uganda: A Population-based Study
Increasing intra-and inter-subtype HIV diversity despite declining HIV incidence in Uganda
Longitudinal patterns in indeterminate HIV rapid antibody test results: a population-based, prospective cohort study
Demographics of sources of HIV-1 transmission in Zambia: a molecular epidemiology analysis in the HPTN 071 PopART study
Trends in HPV Vaccination Before Age 13 Years in the US National Immunization Survey–Teen
...
are the top articles of Thomas C Quinn, MD, MSc at Johns Hopkins University.
What are Thomas C Quinn, MD, MSc's research interests?
The research interests of Thomas C Quinn, MD, MSc are: Infectious Diseases
What is Thomas C Quinn, MD, MSc's total number of citations?
Thomas C Quinn, MD, MSc has 107,591 citations in total.