Steve Horvath
University of California, Los Angeles
H-index: 137
North America-United States
Description
Steve Horvath, With an exceptional h-index of 137 and a recent h-index of 101 (since 2020), a distinguished researcher at University of California, Los Angeles, specializes in the field of Bioinformatics, Human Genetics, Biostatistics, Systems Biology, Network Analysis.
His recent articles reflect a diverse array of research interests and contributions to the field:
Diet Quality and Epigenetic Aging in the Women’s Health Initiative
Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1
Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice
Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans
A Pilot Case-Control Study: Epigenetic Age Acceleration in Psoriasis
DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic aging
Epigenetic aging of human blood cells is influenced by the age of the host body
Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk
Professor Information
University | University of California, Los Angeles |
---|---|
Position | Professor of Human Genetics and Biostatistics |
Citations(all) | 107481 |
Citations(since 2020) | 61124 |
Cited By | 69683 |
hIndex(all) | 137 |
hIndex(since 2020) | 101 |
i10Index(all) | 426 |
i10Index(since 2020) | 363 |
University Profile Page | University of California, Los Angeles |
Research & Interests List
Bioinformatics
Human Genetics
Biostatistics
Systems Biology
Network Analysis
Top articles of Steve Horvath
Diet Quality and Epigenetic Aging in the Women’s Health Initiative
BackgroundHigher diet quality scores are associated with a lower risk for many chronic diseases and all-cause mortality; however, it is unclear if diet quality is associated with aging biology.ObjectiveThis study aimed to examine the association between diet quality and a measure of biological aging – epigenetic aging.DesignA cross-sectional data analysis was used to examine the association between three diet quality scores based on self-reported food frequency questionnaire (FFQ) data and five measures of epigenetic aging based on DNA methylation (DNAm) data from peripheral blood.Participants/setting: This study included 4,500 postmenopausal women recruited from multiple sites across the United States (1993–1998), aged 50–79 years, with FFQ and DNAm data available from the Women’s Health Initiative (WHI) baseline visit.Main outcome measuresFive established epigenetic aging measures were …
Authors
Lindsay M Reynolds,Denise K Houston,Meghan B Skiba,Eric A Whitsel,James D Stewart,Yun Li,Anthony S Zannas,Themistocles L Assimes,Steve Horvath,Parveen Bhatti,Andrea A Baccarelli,Janet A Tooze,Mara Z Vitolins
Journal
Journal of the Academy of Nutrition and Dietetics
Published Date
2024/1/11
Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1
Sex hormones are hypothesized to drive sex-specific health disparities. Here, we study the association between sex steroid hormones and DNA methylation-based (DNAm) biomarkers of age and mortality risk including Pheno Age Acceleration (AA), Grim AA, and DNAm-based estimators of Plasminogen Activator Inhibitor 1 (PAI1), and leptin concentrations. We pooled data from three population-based cohorts, the Framingham Heart Study Offspring Cohort, the Baltimore Longitudinal Study of Aging, and the InCHIANTI Study, including 1,062 postmenopausal women without hormone therapy and 1,612 men of European descent. Sex-stratified analyses using a linear mixed regression were performed, with a Benjamini-Hochberg (BH) adjustment for multiple testing. Sex Hormone Binding Globulin (SHBG) was associated with a decrease in DNAm PAI1 among men (per 1 standard deviation (SD): -478 pg/mL; 95%CI …
Authors
Cynthia DJ Kusters,Kimberly C Paul,Ake T Lu,Luigi Ferruci,Beate R Ritz,Alexandra M Binder,Steve Horvath
Journal
GeroScience
Published Date
2024/2
Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice
Tissue regeneration following an injury requires dynamic cell-state transitions that allow for establishing the cell identities required for the restoration of tissue homeostasis and function. Here, we present a biochemical intervention that induces an intermediate cell state mirroring a transition identified during normal differentiation of myoblasts and other multipotent and pluripotent cells to mature cells. When applied in somatic differentiated cells, the intervention, composed of one-carbon metabolites, reduces some dedifferentiation markers without losing the lineage identity, thus inducing limited reprogramming into a more flexible cell state. Moreover, the intervention enabled accelerated repair after muscle injury in young and aged mice. Overall, our study uncovers a conserved biochemical transitional phase that enhances cellular plasticity in vivo and hints at potential and scalable biochemical interventions of use in …
Authors
Reyna Hernandez-Benitez,Chao Wang,Lei Shi,Yasuo Ouchi,Cuiqing Zhong,Tomoaki Hishida,Hsin-Kai Liao,Eric A Magill,Sebastian Memczak,Rupa D Soligalla,Chiara Fresia,Fumiyuki Hatanaka,Veronica Lamas,Isabel Guillen,Sanjeeb Sahu,Mako Yamamoto,Yanjiao Shao,Alain Aguirre-Vazquez,Estrella Nuñez Delicado,Pedro Guillen,Concepcion Rodriguez Esteban,Jing Qu,Pradeep Reddy,Steve Horvath,Guang-Hui Liu,Pierre Magistretti,Juan Carlos Izpisua Belmonte
Journal
Cell Reports Medicine
Published Date
2024/3/19
Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans
Epigenetic age estimators (clocks) are known to be predictive of human mortality risk. However, it is not yet known whether the epigenetic age of atherosclerotic plaques can be used for predicting secondary events. Here we estimated an age adjusted measure of epigenetic age, epigenetic age acceleration (EAA), using DNA methylation of human atherosclerotic plaques and of blood. EAA of plaque, but not blood, independently predicted secondary events in a 3-year follow-up (HR=1.3, p= 0.018). Plaque EAA concurred with a high metabolic epigenetic and transcriptional state in plaques. Patients with diabetes and a high body mass index had a higher plaque EAA. EAA was lower in female plaques compared to male plaques by approximately 2 years. Single-cell RNA-seq revealed mesenchymal smooth muscle cells and endothelial cells as main drivers of EAA. Plaque-specific ageing may help identify processes that explain poor health outcomes.
Authors
Robin JG Hartman,Ernest Diez Benavente,Lotte Slenders,Arjan Boltjes,Barend M Mol,Gert J de Borst,Dominique PV de Kleijn,Koen HM Prange,Menno PJ de Winther,Johan Kuiper,Mete Civelek,Sander W van der Laan,Steve Horvath,Charlotte Onland-Moret,Michal Mokry,Gerard Pasterkamp,Hester M den Ruijter
Journal
medRxiv
Published Date
2023/2/18
A Pilot Case-Control Study: Epigenetic Age Acceleration in Psoriasis
Psoriasis (PsO) is a chronic inflammatory skin condition, often accompanied by psoriatic arthritis (PsA) and linked to various comorbidities and increased mortality rates. This study aimed to explore the relationship between PsO and accelerated biological aging, specifically focusing on epigenetic DNA methylation clocks. Using a matched case-control design, 20 PsO cases were selected along with age, race, and sex-matched 20 controls without PsO from the Skin Disease Biorepository at Brown Dermatology, Inc, Providence, Rhode Island. Blood samples retrieved from both groups were analyzed for DNA methylation, and epigenetic ages were calculated using DNA methylation clocks, including Horvath, Hannum, Pheno, SkinBlood, and Grim ages. Generalized estimation equations were employed to test the differences in epigenetic and chronological ages between PsO cases and controls, as well as within various subgroups in comparison to their respective controls. There were no statistically significant differences in epigenetic ages between PsO cases and controls. However, notably, PsO cases with PsA demonstrated an accelerated PhenoAge, compared to their matched controls. This study represents a pioneering investigation into the potential link between PsO and epigenetic aging, shedding light on the possibility of accelerated epigenetic aging in PsA, possibly associated with heightened inflammatory burden. These findings emphasize the systemic impact of PsA on the aging process, prompting the need for deeper exploration into autoimmune pathways, inflammation, and epigenetic modifications underlying PsO pathogenesis and …
Authors
Betul Macit,Sara D Ragi,Isabelle Moseley,Janine Molino,John E McGeary,Steve Horvath,Abrar Qureshi,Anthony Reginato,Eunyoung Cho
Published Date
2024/1/4
DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic aging
To address how conserved DNA methylation-based epigenetic aging is in diverse branches of the tree of life, we generated DNA methylation data from African clawed frogs (Xenopus laevis) and Western clawed frogs (Xenopus tropicalis) and built multiple epigenetic clocks. Dual species clocks were developed that apply to both humans and frogs (human-clawed frog clocks), supporting that epigenetic aging processes are evolutionary conserved outside mammals. Highly conserved positively age-related CpGs are located in neural-developmental genes such as uncx, tfap2d as well as nr4a2 implicated in age-associated disease. We conclude that signatures of epigenetic aging are evolutionary conserved between frogs and mammals and that the associated genes relate to neural processes, altogether opening opportunities to employ Xenopus as a model organism to study aging.
Authors
Joseph A Zoller,Eleftheria Parasyraki,Ake T Lu,Amin Haghani,Christof Niehrs,Steve Horvath
Journal
GeroScience
Published Date
2024/2
Epigenetic aging of human blood cells is influenced by the age of the host body
Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over a wide range of donor and recipient age combinations, representing natural experiments of how the age of the recipient affects aging in transplanted donor cells in vivo. We measured DNA methylation and epigenetic aging in donors and recipients and found that biological epigenetic clocks are accelerated in cells transplanted into an older body and decelerated in a younger body. This is the first evidence that the age of the circulating environment influences human epigenetic aging in vivo.
Authors
Petter Holland,Mette Istre,Maryan M Ali,Tobias Gedde‐Dahl,Jochen Buechner,Mari Wildhagen,Sonja H Brunvoll,Steve Horvath,Shigemi Matsuyama,John Arne Dahl,Friedrich Stölzel,Arne Søraas
Journal
Aging Cell
Published Date
2024/3/4
Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk
BackgroundThe study of biological age acceleration may help identify at-risk individuals and reduce the rising global burden of age-related diseases. Using DNA methylation (DNAm) clocks, we investigated biological aging in schizophrenia (SCZ), a mental illness that is associated with an increased prevalence of age-related disabilities and morbidities. In a whole blood DNAm sample of 1090 SCZ cases and 1206 controls across four European cohorts, we performed a meta-analysis of differential aging using three DNAm clocks (i.e., Hannum, Horvath, and Levine). To dissect how DNAm aging contributes to SCZ, we integrated information on duration of illness and SCZ polygenic risk, as well as stratified our analyses by chronological age and biological sex.ResultsWe found that blood-based DNAm aging is significantly altered in SCZ independent from duration of the illness since onset. We observed sex-specific …
Authors
Anil PS Ori,Loes M Olde Loohuis,Jerry Guintivano,Eilis Hannon,Emma Dempster,David St. Clair,Nick J Bass,Andrew McQuillin,Jonathan Mill,Patrick F Sullivan,Rene S Kahn,Steve Horvath,Roel A Ophoff
Journal
Clinical Epigenetics
Published Date
2024/4/8
Professor FAQs
What is Steve Horvath's h-index at University of California, Los Angeles?
The h-index of Steve Horvath has been 101 since 2020 and 137 in total.
What are Steve Horvath's top articles?
The articles with the titles of
Diet Quality and Epigenetic Aging in the Women’s Health Initiative
Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1
Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice
Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans
A Pilot Case-Control Study: Epigenetic Age Acceleration in Psoriasis
DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic aging
Epigenetic aging of human blood cells is influenced by the age of the host body
Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk
...
are the top articles of Steve Horvath at University of California, Los Angeles.
What are Steve Horvath's research interests?
The research interests of Steve Horvath are: Bioinformatics, Human Genetics, Biostatistics, Systems Biology, Network Analysis
What is Steve Horvath's total number of citations?
Steve Horvath has 107,481 citations in total.
What are the co-authors of Steve Horvath?
The co-authors of Steve Horvath are Aarno Palotie, Eric Schadt, Harry V. Vinters, Jonathan Mill, Timothy Cloughesy, Roel A. Ophoff.