Sahab Babaee
Massachusetts Institute of Technology
H-index: 16
North America-United States
About Sahab Babaee
Sahab Babaee, With an exceptional h-index of 16 and a recent h-index of 15 (since 2020), a distinguished researcher at Massachusetts Institute of Technology, specializes in the field of Biomedical Engineering, Translational Medicine, Medical Device Development, Solid Mechanics and Materials, Computational Science.
His recent articles reflect a diverse array of research interests and contributions to the field:
Thermally controlled residence devices
Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation
Continuous production of highly functional vascularized hepatobiliary organoids from human pluripotent stem cells using a scalable microfluidic platform
Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens
Endovascular injectable stents for cardiovascular drug delivery
Thermally controlled reconfigurable medical devices
Millineedle systems for esophageal drug delivery
Low-cost gastrointestinal manometry via silicone–liquid-metal pressure transducers resembling a quipu
Sahab Babaee Information
University | Massachusetts Institute of Technology |
---|---|
Position | ___ |
Citations(all) | 2040 |
Citations(since 2020) | 1402 |
Cited By | 1201 |
hIndex(all) | 16 |
hIndex(since 2020) | 15 |
i10Index(all) | 17 |
i10Index(since 2020) | 15 |
University Profile Page | Massachusetts Institute of Technology |
Sahab Babaee Skills & Research Interests
Biomedical Engineering
Translational Medicine
Medical Device Development
Solid Mechanics and Materials
Computational Science
Top articles of Sahab Babaee
Thermally controlled residence devices
Published Date
2023/5/16
Residence devices for long term delivery of therapeutic compounds and/or for sensing one or more relevant parameters in vivo are disclosed. In one embodiment, a residence device may include a plurality of links interconnected by a corresponding plurality of flexible hinges to permit the residence device to be deformed into a contracted configuration and subsequently permitted to return to an expanded configuration once positioned in a desired location, such as the stomach, of a subject. In some instances, at least a portion of the interconnected links may include a first link segment, a second link segment, and a coupling that selectively connects the first link segment to the second link segment. The coupling may be configured to weaken or decouple a connection between the first link segment and the second link segment when exposed to a temperature greater than a threshold temperature to selectively weaken …
Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation
Authors
Khalil B Ramadi,James C McRae,George Selsing,Arnold Su,Rafael Fernandes,Maela Hickling,Brandon Rios,Sahab Babaee,Seokkee Min,Declan Gwynne,Neil Zixun Jia,Aleyah Aragon,Keiko Ishida,Johannes Kuosmanen,Josh Jenkins,Alison Hayward,Ken Kamrin,Giovanni Traverso
Journal
Science robotics
Published Date
2023/4/26
The gut-brain axis, which is mediated via enteric and central neurohormonal signaling, is known to regulate a broad set of physiological functions from feeding to emotional behavior. Various pharmaceuticals and surgical interventions, such as motility agents and bariatric surgery, are used to modulate this axis. Such approaches, however, are associated with off-target effects or post-procedure recovery time and expose patients to substantial risks. Electrical stimulation has also been used to attempt to modulate the gut-brain axis with greater spatial and temporal resolution. Electrical stimulation of the gastrointestinal (GI) tract, however, has generally required invasive intervention for electrode placement on serosal tissue. Stimulating mucosal tissue remains challenging because of the presence of gastric and intestinal fluid, which can influence the effectiveness of local luminal stimulation. Here, we report the …
Continuous production of highly functional vascularized hepatobiliary organoids from human pluripotent stem cells using a scalable microfluidic platform
Authors
Saeed Abbasalizadeh,Sahab Babaee,Reza Kowsari‐Esfahan,Zahra Mazidi,Yichao Shi,Jake Wainer,Joaquim MS Cabral,Robert Langer,Giovanni Traverso,Hossein Baharvand
Journal
Advanced Functional Materials
Published Date
2023/12
“Organoid medicine” has rapidly progressed over the past decade as a new class of therapeutics with high functionality and complexity for addressing unmet medical needs such as effective treatment of patients suffering from chronic liver disease using liver organoids. Here, scalable and xeno‐free integrated differentiation platforms are established to generate hepatic progenitors, mesenchymal stromal cells, and endothelial cells using individual human pluripotent stem cell lines as starting cell types for vascularized liver organoids generation. A scalable microfluidic system is developed to continuously generate cells‐loaded microcapsules with self‐biodegradable 4‐arm‐PEG‐MMP1‐sensitive peptide hydrogel as shell material, to support cells proliferation, self‐condensation, and liver organoids generation through self‐organization. Self‐organized vascularized hepatobiliary organoids (VHOs) containing …
Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens
Authors
Christina Karavasili,Sahab Babaee,Shruti Kutty,Jacqueline N Chu,Seokkee Min,Nina Fitzgerald,Joshua Morimoto,Nicoletta Inverardi,Giovanni Traverso
Journal
Advanced healthcare materials
Published Date
2023/10
Simplification of complex medication regimens in polypharmacy positively contributes to treatment adherence and cost‐effective improved health outcomes. Even though fixed dose combination (FDC) drug products are the only currently available single dose poly‐pill regimens, the lack of flexibility in dose adjustment of a single drug in the combination limits their efficacy. To fill the existing gap in drug dose personalization and simplification of complex medication regimens commonly encountered in the treatment of cardiovascular disease, tuberculosis, and tapering of corticosteroid therapy, a modular titratable polypill approach that simultaneously addresses both aspects is proposed. The polypill consists of modular units that contain different drugs at incremental or decremental doses to be assembled in a single titratable polypill at the required dose for each drug through a stacking or interlocking process. The …
Endovascular injectable stents for cardiovascular drug delivery
Published Date
2023/9/21
Herein is described a stent platform capable of intravascular local delivery of therapeutics through multipoint injection of drug agents into the vascular walls and endocardial surfaces. More specifically, an endovascular injectable stent made of kirigami skin is wrapped around a soft linear actuator and used for intravascular local drug delivery of therapeutics. This platform addresses an unmet need of treating aortic stenosis and atherosclerotic cardiovascular disease.
Thermally controlled reconfigurable medical devices
Published Date
2022/1/27
Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigur able medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively recon figure the reconfigurable device between a retracted con figuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the
Millineedle systems for esophageal drug delivery
Published Date
2022/1/13
Applicants: Massachusetts Institute of Technology, Cambridge, MA (US); The Brigham and Women's Hospital, Inc., Boston, MA (US)(72) Inventors: Robert S. Langer, Newton, MA (US); Carlo Giovanni Traverso, Newton, MA (US); Ester Caffarel Salvador, Cambridge, MA (US); Sahab Babaee, Arlington, MA (US); Simo Pajovic, Mississauga (CA)
Low-cost gastrointestinal manometry via silicone–liquid-metal pressure transducers resembling a quipu
Authors
Kewang Nan,Sahab Babaee,Walter W Chan,Johannes LP Kuosmanen,Vivian R Feig,Yiyue Luo,Shriya S Srinivasan,Christina M Patterson,Ahmad Mujtaba Jebran,Giovanni Traverso
Journal
Nature Biomedical Engineering
Published Date
2022/10
The evaluation of the tone and contractile patterns of the gastrointestinal (GI) tract via manometry is essential for the diagnosis of GI motility disorders. However, manometry is expensive and relies on complex and bulky instrumentation. Here we report the development and performance of an inexpensive and easy-to-manufacture catheter-like device for capturing manometric data across the dynamic range observed in the human GI tract. The device, which we designed to resemble the quipu—knotted strings used by Andean civilizations for the capture and transmission of information—consists of knotted piezoresistive pressure sensors made by infusing a liquid metal (eutectic gallium-indium) through thin silicone tubing. By exploring a range of knotting configurations, we identified optimal design schemes that led to sensing performances comparable to those of commercial devices for GI manometry, as we show for …
Biodegradable ring-shaped implantable device for intravesical therapy of bladder disorders
Authors
Hyunjoon Kim,Seung Ho Lee,Adam Wentworth,Sahab Babaee,Kaitlyn Wong,Joy E Collins,Jacqueline Chu,Keiko Ishida,Johannes Kuosmanen,Joshua Jenkins,Kaitlyn Hess,Aaron Lopes,Joshua Morimoto,Qianqian Wan,Shaunak V Potdar,Ronan McNally,Caitlynn Tov,Na Yoon Kim,Alison Hayward,Daniel Wollin,Robert Langer,Giovanni Traverso
Journal
Biomaterials
Published Date
2022/9/1
Intravesical instillation is an efficient drug delivery route for the local treatment of various urological conditions. Nevertheless, intravesical instillation is associated with several challenges, including pain, urological infection, and frequent clinic visits for catheterization; these difficulties support the need for a simple and easy intravesical drug delivery platform. Here, we propose a novel biodegradable intravesical device capable of long-term, local drug delivery without a retrieval procedure. The intravesical device is composed of drug encapsulating biodegradable polycaprolactone (PCL) microcapsules and connected by a bioabsorbable Polydioxanone (PDS) suture with NdFeB magnets in the end. The device is easily inserted into the bladder and forms a ‘ring’ shape optimized for maximal mechanical stability as informed by finite element analysis. In this study, inserted devices were retained in a swine model for 4 …
Systems and methods for adjusting friction
Published Date
2022/4/14
A shoe comprises an upper portion, a sole, and a sheet of material. The upper portion is configured to receive a foot of a user. The sole is attached to the upper portion. The sheet of material is coupled to the sole. The material includes a substrate and one or more movable projections. The one or more movable projections are configured to extend from the substrate. The one or more movable projections are configured to move between a first orientation and a second orientation relative to the substrate, in response to the sole of the shoe moving between a generally flat configuration and a generally flexed configuration. The movable projections can have a triangular shape, a concave shape, a convex shape, a rectangular shape, or a barbed shape; and can be arranged in a one-direction pattern, a three-column pattern, a half pattern, a 16x2 pattern, or a checkerboard pattern.
Kirigami-inspired stents for sustained local delivery of therapeutics
Published Date
2021/12/23
Inventors: Sahab BABAEE, Arlington, MA (US); Yichao SHI, Burlington (CA); Saeed ABBASALIZADEH, Tehran (IR); Robert LANGER, Newton, MA (US); Carlo TRAVERSO, Newton, MA (US)
Injection Molded Autoclavable, Scalable, Conformable (iMASC) system for aerosol-based protection: A prospective single-arm feasibility study
Authors
James D Byrne,Adam J Wentworth,Peter R Chai,Hen-Wei Huang,Sahab Babaee,Canchen Li,Sarah L Becker,Caitlynn Tov,Seokkee Min,Giovanni Traverso
Journal
BMJ open
Published Date
2020/7/1
ObjectiveTo develop and test a new reusable, sterilisable N95 filtering facepiece respirator (FFR)-comparable face mask, known as the Injection Molded Autoclavable, Scalable, Conformable (iMASC) system, given the dire need for personal protective equipment within healthcare settings during the COVID-19 pandemic.DesignSingle-arm feasibility study.SettingEmergency department and outpatient oncology clinic.ParticipantsHealthcare workers who have previously undergone N95 fit testing.InterventionsFit testing of new iMASC system.Primary and secondary outcome measuresPrimary outcome is success of fit testing using an Occupational Safety and Health Administration (OSHA)-approved testing method, and secondary outcomes are user experience with fit, breathability and filter replacement.ResultsTwenty-four subjects were recruited to undergo fit testing, and the average age of subjects was 41 years …
Prospective evaluation of the transparent, elastomeric, adaptable, long-lasting (TEAL) respirator
Authors
Adam J Wentworth,James D Byrne,Sirma Orguc,Joanna Sands,Saurav Maji,Caitlynn Tov,Sahab Babaee,Hen-Wei Huang,Hannah Boyce,Peter R Chai,Seokkee Min,Canchen Li,Jacqueline N Chu,Avik Som,Sarah L Becker,Manish Gala,Anantha Chandrakasan,Giovanni Traverso
Journal
ACS Pharmacology & Translational Science
Published Date
2020/11/10
N95 filtering facepiece respirators (FFR) and surgical masks are essential in reducing airborne disease transmission, particularly during the COVID-19 pandemic. However, currently available FFR’s and masks have major limitations, including masking facial features, waste, and integrity after decontamination. In a multi-institutional trial, we evaluated a transparent, elastomeric, adaptable, long-lasting (TEAL) respirator to evaluate success of qualitative fit test with user experience and biometric evaluation of temperature, respiratory rate, and fit of respirator using a novel sensor. There was a 100% successful fit test among participants, with feedback demonstrating excellent or good fit (90% of participants), breathability (77.5%), and filter exchange (95%). Biometric testing demonstrated significant differences between exhalation and inhalation pressures among a poorly fitting respirator, well-fitting respirator, and the …
Bioinspired kirigami metasurfaces as assistive shoe grips
Authors
Sahab Babaee,Simo Pajovic,Ahmad Rafsanjani,Yichao Shi,Katia Bertoldi,Giovanni Traverso
Journal
Nature Biomedical Engineering
Published Date
2020/8
Falls and subsequent complications are major contributors to morbidity and mortality, especially in older adults. Here, by taking inspiration from claws and scales found in nature, we show that buckling kirigami structures applied to footwear outsoles generate higher friction forces in the forefoot and transversally to the direction of movement. We identified optimal kirigami designs capable of modulating friction for a range of surfaces, including ice, by evaluating the performance of the dynamic kirigami outsoles through numerical simulations and in vitro friction testing, as well as via human-gait force-plate measurements. We anticipate that lightweight kirigami metasurfaces applied to footwear outsoles could help mitigate the risk of slips and falls in a range of environments.
Sahab Babaee FAQs
What is Sahab Babaee's h-index at Massachusetts Institute of Technology?
The h-index of Sahab Babaee has been 15 since 2020 and 16 in total.
What are Sahab Babaee's top articles?
The articles with the titles of
Thermally controlled residence devices
Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation
Continuous production of highly functional vascularized hepatobiliary organoids from human pluripotent stem cells using a scalable microfluidic platform
Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens
Endovascular injectable stents for cardiovascular drug delivery
Thermally controlled reconfigurable medical devices
Millineedle systems for esophageal drug delivery
Low-cost gastrointestinal manometry via silicone–liquid-metal pressure transducers resembling a quipu
...
are the top articles of Sahab Babaee at Massachusetts Institute of Technology.
What are Sahab Babaee's research interests?
The research interests of Sahab Babaee are: Biomedical Engineering, Translational Medicine, Medical Device Development, Solid Mechanics and Materials, Computational Science
What is Sahab Babaee's total number of citations?
Sahab Babaee has 2,040 citations in total.
What are the co-authors of Sahab Babaee?
The co-authors of Sahab Babaee are Robert Langer, Dragomir Neshev, James C. Weaver, Katia Bertoldi, Nick Fang, Ilya Shadrivov.