Richard Tsien
New York University
H-index: 142
North America-United States
Description
Richard Tsien, With an exceptional h-index of 142 and a recent h-index of 52 (since 2020), a distinguished researcher at New York University, specializes in the field of Neuronal signaling, calcium channels, neuromodulation, homeostasis, synaptic plasticity.
His recent articles reflect a diverse array of research interests and contributions to the field:
SUGGESTED SEARCHES
Interaction of acetylcholine and oxytocin neuromodulation in the hippocampus
A dedicated hypothalamic oxytocin circuit controls aversive social learning
Structural characterization of a complex repeat at the CACNA1C pan-psychiatric locus
Functional specialization of hippocampal somatostatin-expressing interneurons
Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity
Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity
Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons
Professor Information
University | New York University |
---|---|
Position | NYU School of Medicine |
Citations(all) | 80277 |
Citations(since 2020) | 8356 |
Cited By | 73191 |
hIndex(all) | 142 |
hIndex(since 2020) | 52 |
i10Index(all) | 281 |
i10Index(since 2020) | 155 |
University Profile Page | New York University |
Research & Interests List
Neuronal signaling
calcium channels
neuromodulation
homeostasis
synaptic plasticity
Top articles of Richard Tsien
SUGGESTED SEARCHES
Monocytes comprise two major subsets, Ly6C hi classical monocytes and Ly6C lo nonclassical monocytes. Notch2 signaling in Ly6C hi monocytes triggers transition to Ly6C lo monocytes, which require Nr4a1, Bcl6, Irf2, and Cebpb. By comparison, less is known...
Authors
Sunkyung Kim,Jing Chen,Feiya Ou,Tian-Tian Liu,Suin Jo,William E Gillanders,Kenneth M Murphy,Dengfeng Guan,Shuyan Sun,Lingyun Song,Pengpeng Zhao,Yonggang Nie,Xin Huang,Wenliang Zhou,Li Yan,Yinghu Lei,Fuwen Wei,Daiki Shinozaki,Erina Takayama,Kohki Yoshimoto,Carolyn Beans,Stefania Morales-Herrera,Joris Jourquin,Frederic Coppé,Lorena Lopez-Galvis,Tom De Smet,Alaeddine Safi,Maria Njo,Cara A Griffiths,John D Sidda,James SO Mccullagh,Xiaochao Xue,Benjamin G Davis,Johan Van der Eycken,Matthew J Paul,Tom Beeckman,Takuya Noguchi,Yuto Sekiguchi,Tatsuya Shimada,Wakana Suzuki,Takumi Yokosawa,Tamaki Itoh,Mayuka Yamada,Midori Suzuki,Reon Kurokawa,Atsushi Matsuzawa,Ji-Young Kim,Connor McGlothin,Minjeong Cha,Zechariah J Pfaffenberger,Emine Sumeyra Turali Emre,Wonjin Choi,Sanghoon Kim,Nicholas A Kotov,Zhuan Chen,Faliang An,Yayun Zhang,Zhiyan Liang,Mingyang Xing,Hong Ao,Jiaoyang Ruan,María Martinón-Torres,Mario Krapp,Diederik Liebrand,Mark J Dekkers,Thibaut Caley,Tara N Jonell,Zongmin Zhu,Chunju Huang,Xinxia Li,Ziyun Zhang,Qiang Sun,Pingguo Yang,Jiali Jiang,Xinzhou Li,Xiaoxun Xie,Yougui Song,Xiaoke Qiang,Zhisheng An,Zu-Lin Chen,Pradeep K Singh,Marissa Calvano,Sidney Strickland,Jacob Freeman,Erick Robinson,Darcy Bird,Robert J Hard,John M Anderies,Giulia Giubertoni,Liru Feng,Kevin Klein,Guido Giannetti,Luco Rutten,Yeji Choi,Anouk van der Net,Gerard Castro-Linares,Federico Caporaletti,Dimitra Micha,Johannes Hunger,Antoine Deblais
Journal
Perspective
Published Date
2024/3/4
Interaction of acetylcholine and oxytocin neuromodulation in the hippocampus
A postulated role of subcortical neuromodulators is to control brain states. Mechanisms by which different neuromodulators compete or cooperate at various temporal scales remain an open question. We investigated the interaction of acetylcholine (ACh) and oxytocin (OXT) at slow and fast timescales during various brain states. Although these neuromodulators fluctuated in parallel during NREM packets, transitions from NREM to REM were characterized by a surge of ACh but a continued decrease of OXT. OXT signaling lagged behind ACh. High ACh was correlated with population synchrony and gamma oscillations during active waking, whereas minimum ACh predicts sharp-wave ripples (SPW-Rs). Optogenetic control of ACh and OXT neurons confirmed the active role of these neuromodulators in the observed correlations. Synchronous hippocampal activity consistently reduced OXT activity, whereas …
Authors
Yiyao Zhang,Mursel Karadas,JingJing Liu,Xinyi Gu,Mihály Vöröslakos,Yulong Li,Richard W Tsien,György Buzsáki
Journal
Neuron
Published Date
2024/3/18
A dedicated hypothalamic oxytocin circuit controls aversive social learning
To survive in a complex social group, one needs to know who to approach and, more importantly, who to avoid. In mice, a single defeat causes the losing mouse to stay away from the winner for weeks. Here through a series of functional manipulation and recording experiments, we identify oxytocin neurons in the retrochiasmatic supraoptic nucleus (SOROXT) and oxytocin-receptor-expressing cells in the anterior subdivision of the ventromedial hypothalamus, ventrolateral part (aVMHvlOXTR) as a key circuit motif for defeat-induced social avoidance. Before defeat, aVMHvlOXTR cells minimally respond to aggressor cues. During defeat, aVMHvlOXTR cells are highly activated and, with the help of an exclusive oxytocin supply from the SOR, potentiate their responses to aggressor cues. After defeat, strong aggressor-induced aVMHvlOXTR cell activation drives the animal to avoid the aggressor and minimizes future …
Authors
Takuya Osakada,Rongzhen Yan,Yiwen Jiang,Dongyu Wei,Rina Tabuchi,Bing Dai,Xiaohan Wang,Gavin Zhao,Clara Xi Wang,Jing-Jing Liu,Richard W Tsien,Adam C Mar,Dayu Lin
Journal
Nature
Published Date
2024/1/24
Structural characterization of a complex repeat at the CACNA1C pan-psychiatric locus
Genetic variation within intron 3 of CACNA1C surrounding a variable-number tandem repeat (VNTR) is associated with schizophrenia and bipolar disorder, but the causal variant(s) and their effects remain unclear. We fine-mapped the association at CACNA1C including this VNTR using sequences from 155 long-read genome assemblies. Across global populations, we found 7 alleles (called Types) of the CACNA1C VNTR where sequence differences within repeat units revealed distinct VNTR structure. Within the most common VNTR Type, a previously identified polymorphism of repeat unit composition (termed Variable Region 2) was in complete linkage disequilibrium with fine-mapped schizophrenia SNPs. Applying a genotyping strategy to GTEx data that capitalizes on sequence differences between repeat units, we found that the eQTL in brain tissues at Variable Region 2 had a similar effect size and significance as SNP eQTLs. We show that the risk allele of Variable Region 2 decreases CACNA1C gene expression. Our long-read-informed approach to genotype structurally complex VNTR alleles in large cohorts permits investigation of other variants missed by short-read sequencing. Our work suggests an effect on gene expression arising from sequence variation within a VNTR and provides a detailed characterization of new alleles at a flagship psychiatric GWAS locus.
Authors
Raquel Moya,Xiaohan Wang,Richard W Tsien,Matthew T Maurano
Journal
medRxiv
Published Date
2024
Functional specialization of hippocampal somatostatin-expressing interneurons
Hippocampal somatostatin-expressing (Sst) GABAergic interneurons (INs) exhibit considerable anatomical and functional heterogeneity. Recent single-cell transcriptome analyses have provided a comprehensive Sst-IN subpopulations census, a plausible molecular ground truth of neuronal identity whose links to specific functionality remain incomplete. Here, we designed an approach to identify and access subpopulations of Sst-INs based on transcriptomic features. Four mouse models based on single or combinatorial Cre- and Flp- expression differentiated functionally distinct subpopulations of CA1 hippocampal Sst-INs that largely tiled the morpho-functional parameter space of the Sst-INs superfamily. Notably, the Sst;;Tac1 intersection revealed a population of bistratified INs that preferentially synapsed onto fast-spiking interneurons (FS-INs) and were sufficient to interrupt their firing. In contrast, the Ndnf;;Nkx2-1 …
Authors
Simon Chamberland,Gariel Grant,Robert Machold,Erica R Nebet,Guoling Tian,Joshua Stich,Monica Hanani,Klas Kullander,Richard W Tsien
Journal
Proceedings of the National Academy of Sciences
Published Date
2024/4/23
Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity
Neurons use various forms of negative feedback to maintain their synaptic strengths within an operationally useful range. While this homeostatic plasticity is thought to distinctly counteract the destabilizing positive feedback of Hebbian plasticity, there is considerable overlap in the molecular components mediating both forms of plasticity. The varying kinetics of these components spurs additional inquiry into the dynamics of synaptic homeostasis. We discovered that upscaling of synaptic weights in response to prolonged inactivity is nonmonotonic. Surprisingly, this seemingly oscillatory adaptation involved transient appropriation of molecular effectors associated with Hebbian plasticity, namely CaMKII, L-type Ca2+ channels, and Ca2+-permeable AMPARs, and homeostatic elements such as calcineurin. We created a dynamic model that shows how traditionally “Hebbian” and “homeostatic” mechanisms can cooperate to autoregulate postsynaptic Ca2+ levels. We propose that this combination of mechanisms allows excitatory synapses to adapt to prolonged activity changes and safeguard the capability to undergo future strengthening on demand.
Authors
Simón (e) D Sun,Daniel Levenstein,Boxing Li,Nataniel Mandelberg,Nicolas Chenouard,Benjamin S Suutari,Sandrine Sanchez,Guoling Tian,John Rinzel,György Buzsáki,Richard W Tsien
Journal
bioRxiv
Published Date
2022/6/19
Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity
Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in multiple forms of pediatric epilepsies, but the mechanism(s) of anti-seizure action remain unclear. In one leading model, CBD acts at glutamatergic axon terminals, blocking the pro-excitatory actions of an endogenous membrane phospholipid, lysophosphatidylinositol (LPI), at the G-protein-coupled receptor GPR55. However, the impact of LPI-GPR55 signaling at inhibitory synapses and in epileptogenesis remains underexplored. We found that LPI transiently increased hippocampal CA3-CA1 excitatory presynaptic release probability and evoked synaptic strength in WT mice, while attenuating inhibitory postsynaptic strength by decreasing GABAARγ2 and gephyrin puncta. LPI effects at excitatory and inhibitory synapses were eliminated by CBD pre-treatment and absent after GPR55 deletion. Acute pentylenetrazole-induced seizures …
Authors
Evan C Rosenberg,Simon Chamberland,Michael Bazelot,Erica R Nebet,Xiaohan Wang,Sam McKenzie,Swati Jain,Stuart Greenhill,Max Wilson,Nicole Marley,Alejandro Salah,Shanice Bailey,Pabitra Hriday Patra,Rebecca Rose,Nicolas Chenouard,Drew Jones,György Buzsáki,Orrin Devinsky,Gavin Woodhall,Helen E Scharfman,Benjamin J Whalley,Richard W Tsien
Journal
Neuron
Published Date
2023/4/19
Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons
Neurons perform input-output operations that integrate synaptic inputs with intrinsic electrical properties; these operations are generally constrained by the brevity of synaptic events. Here, we report that sustained firing of CA1 hippocampal fast-spiking parvalbumin-expressing interneurons (PV-INs) can be persistently interrupted for several hundred milliseconds following brief GABAAR-mediated inhibition in vitro and in vivo. A single presynaptic neuron could interrupt PV-IN firing, occasionally with a single action potential (AP), and reliably with AP bursts. Experiments and computational modeling reveal that the persistent interruption of firing maintains neurons in a depolarized, quiescent state through a cell-autonomous mechanism. Interrupted PV-INs are strikingly responsive to Schaffer collateral inputs. The persistent interruption of firing provides a disinhibitory circuit mechanism favoring spike generation in CA1 …
Authors
Simon Chamberland,Erica R Nebet,Manuel Valero,Monica Hanani,Robert Egger,Samantha B Larsen,Katherine W Eyring,György Buzsáki,Richard W Tsien
Journal
Neuron
Published Date
2023/4/19
Professor FAQs
What is Richard Tsien's h-index at New York University?
The h-index of Richard Tsien has been 52 since 2020 and 142 in total.
What are Richard Tsien's top articles?
The articles with the titles of
SUGGESTED SEARCHES
Interaction of acetylcholine and oxytocin neuromodulation in the hippocampus
A dedicated hypothalamic oxytocin circuit controls aversive social learning
Structural characterization of a complex repeat at the CACNA1C pan-psychiatric locus
Functional specialization of hippocampal somatostatin-expressing interneurons
Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity
Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity
Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons
...
are the top articles of Richard Tsien at New York University.
What are Richard Tsien's research interests?
The research interests of Richard Tsien are: Neuronal signaling, calcium channels, neuromodulation, homeostasis, synaptic plasticity
What is Richard Tsien's total number of citations?
Richard Tsien has 80,277 citations in total.