Renwei Chen
University of California, Santa Barbara
H-index: 20
North America-United States
About Renwei Chen
Renwei Chen, With an exceptional h-index of 20 and a recent h-index of 15 (since 2020), a distinguished researcher at University of California, Santa Barbara, specializes in the field of Interdisciplinary Research in Life Science.
His recent articles reflect a diverse array of research interests and contributions to the field:
The TLE1 transcriptional and epigenetic machinery contributes to EGFR targeted therapy resistance in human lung adenocarcinoma
Oral drug delivery devices and methods using iontophoresis
Investigating the potential use of an ionic liquid (1-Butyl-1-methylpyrrolidinium bis (trifluoromethylsulfonyl) imide) as an anti-fungal treatment against the amphibian chytrid …
Renwei Chen Information
University | University of California, Santa Barbara |
---|---|
Position | ___ |
Citations(all) | 1822 |
Citations(since 2020) | 828 |
Cited By | 1652 |
hIndex(all) | 20 |
hIndex(since 2020) | 15 |
i10Index(all) | 24 |
i10Index(since 2020) | 18 |
University Profile Page | University of California, Santa Barbara |
Renwei Chen Skills & Research Interests
Interdisciplinary Research in Life Science
Top articles of Renwei Chen
The TLE1 transcriptional and epigenetic machinery contributes to EGFR targeted therapy resistance in human lung adenocarcinoma
Authors
Hector Ramos Biliran,Xin Yao,Nasir Roberts,Prince Iheukwumere,Renwei Chen,Ma Carmela Dela Cruz
Journal
Cancer Research
Published Date
2024/3/22
In human lung adenocarcinoma that carry Epidermal Growth Factor Receptor (EGFR) sensitizing mutations, targeting the EGFR pathway with the use of EGFR tyrosine kinase inhibitors (EGFR-TKIs) has emerged as a promising therapeutic strategy providing initial clinical benefit to many patients. Unfortunately, resistance to EGFR-TKIs eventually develops leading to disease progression. In addition to genetic mutations, transcriptional and epigenetic mediated changes in gene expression remain an important mechanism contributing to EGFR-TKI resistance. Here, we report a novel function of the transcriptional corepressor Transducin-Like Enhancer of Split-1 (TLE1) in mediating EGFR-TKI resistance in EGFR mutant LUAD cells through its survival promoting gene transcriptional program. In EGFR mutant, EGFR TKI sensitive LUAD cells, sole activation of the TLE1 nuclear function attenuates EGFR TKI sensitivity …
Oral drug delivery devices and methods using iontophoresis
Published Date
2020/7/30
Disclosed herein are methods, systems, and devices for oral drug delivery. The method generally involves orally administering a drug delivery device to the subject in need of treatment and triggering iontophoresis. The drug delivery device includes one or more active agents for delivery to the subject. The method can include the step of delivering the active agent to the intestinal mucosa after iontophoresis is triggered at the site, or simultaneously as iontophoresis is applied at the site. After the active agent (s) are delivered, the drug delivery device can be released from the intestinal mucosa. The iontophoresis can be performed for a period of time and at an electrical current that is effective to improve permeability of the one or more active agents across the intestine compared to orally administering the same drug delivery device in the absence of iontophoresis.
Investigating the potential use of an ionic liquid (1-Butyl-1-methylpyrrolidinium bis (trifluoromethylsulfonyl) imide) as an anti-fungal treatment against the amphibian chytrid …
Authors
Graziella V DiRenzo,Renwei Chen,Kelly Ibsen,Mary Toothman,Abigail J Miller,Ariel Gershman,Samir Mitragotri,Cheryl J Briggs
Journal
PLoS One
Published Date
2020/4/17
The disease chytridiomycosis, caused by the pathogenic chytrid fungus, Batrachochytrium dendrobatidis (Bd), has contributed to global amphibian declines. Bd infects the keratinized epidermal tissue in amphibians and causes hyperkeratosis and excessive skin shedding. In individuals of susceptible species, the regulatory function of the amphibian’s skin is disrupted resulting in an electrolyte depletion, osmotic imbalance, and eventually death. Safe and effective treatments for chytridiomycosis are urgently needed to control chytrid fungal infections and stabilize populations of endangered amphibian species in captivity and in the wild. Currently, the most widely used anti-Bd treatment is itraconazole. Preparations of itraconazole formulated for amphibian use has proved effective, but treatment involves short baths over seven to ten days, a process which is logistically challenging, stressful, and causes long-term health effects. Here, we explore a novel anti-fungal therapeutic using a single application of the ionic liquid, 1-Butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide (BMP-NTf2), for the treatment of chytridiomycosis. BMP-NTf2 was found be effective at killing Bd in vitro at low concentrations (1:1000 dilution). We tested BMP-NTf2 in vivo on two amphibian species, one that is relatively tolerant of chytridiomycosis (Pseudacris regilla) and one that is highly susceptible (Dendrobates tinctorius). A toxicity trial revealed a surprising interaction between Bd infection status and the impact of BMP-NTf2 on D. tinctorius survival. Uninfected D. tinctorius tolerated BMP-NTf2 (mean ± SE; 96.01 ± 9.00 μl/g), such that only 1 out of 30 frogs died …
Renwei Chen FAQs
What is Renwei Chen's h-index at University of California, Santa Barbara?
The h-index of Renwei Chen has been 15 since 2020 and 20 in total.
What are Renwei Chen's top articles?
The articles with the titles of
The TLE1 transcriptional and epigenetic machinery contributes to EGFR targeted therapy resistance in human lung adenocarcinoma
Oral drug delivery devices and methods using iontophoresis
Investigating the potential use of an ionic liquid (1-Butyl-1-methylpyrrolidinium bis (trifluoromethylsulfonyl) imide) as an anti-fungal treatment against the amphibian chytrid …
are the top articles of Renwei Chen at University of California, Santa Barbara.
What are Renwei Chen's research interests?
The research interests of Renwei Chen are: Interdisciplinary Research in Life Science
What is Renwei Chen's total number of citations?
Renwei Chen has 1,822 citations in total.
What are the co-authors of Renwei Chen?
The co-authors of Renwei Chen are Samir Mitragotri, Klaus Hedman, Cheryl J. Briggs, Dennis Clegg, Otger Campas, Hector Biliran, Ph.D..