Peter Libby

BackgroundThe dual SGLT 1 and 2 inhibitor sotagliflozin (sota) reduced atherothrombotic events and hospitalization for worsening heart failure in patients with diabetes in clinical trials (SCORED, SOLOIST, respectively). Unlike selective SGLT2 inhibitors such as empagliflozin (empa), treatment with sota reduced ischemic events. We compared the effects of sota and empa on expression of proteins in human vein ECs (HUVECs) subjected to inflammatory challenge.MethodsHUVECs were treated with sota or empa (100 nM) for 30 minutes and then challenged with angiotensin II (Ang II) at 100 nM or lipopolysaccharide (LPS) at 100 ng/mL for 24 h. Global proteomic analysis was performed using LC/MS to simultaneously measure relative protein expression levels. Differential enrichment analysis of proteomics data (DEP) was applied to all the raw mass spectrometry data, and only significant (p< 0.05) changes in …

Dirigido a los profesionales de la atención primaria, recoge las últimas actualizaciones en cardiología preventiva y en enfermedad cardiovascular en poblaciones especiales, como ancianos, mujeres, gestantes, etc. Se incluyen nuevos capítulos de interés para los especialistas de atención primaria. La gripe y la COVID-19, y su relación con el sistema cardiovascular; los riesgos cardiovasculares de los productos del tabaco, y el impacto medioambiental sobre la salud cardiovascular son algunas de las novedades más relevantes. Hereda de su matriz, la duodécima edición de Braunwald. Tratado de cardiología, un contenido equilibrado y riguroso de la ciencia y la investigación clínicas, rápidamente cambiantes, y la medicina basada en la evidencia. Dirigido a los profesionales de la atención primaria, recoge las últimas actualizaciones en cardiología preventiva y en enfermedad cardiovascular en poblaciones especiales, como ancianos, mujeres, gestantes, etc. Se incluyen nuevos capítulos de interés para los especialistas de atención primaria. La gripe y la COVID-19, y su relación con el sistema cardiovascular; los riesgos cardiovasculares de los productos del tabaco, y el impacto medioambiental sobre la salud cardiovascular son algunas de las novedades más relevantes. Hereda de su matriz, la duodécima edición de Braunwald. Tratado de cardiología, un contenido equilibrado y riguroso de la ciencia y la investigación clínicas, rápidamente cambiantes, y la medicina basada en la evidencia.

As the new year begins, the editorial team thanks all of our reviewers who have worked tirelessly to maintain the quality and the integrity of the review process for JACC: Basic to Translational Science. Given the diverse range of scientific articles that we publish, identifying reviewers with the necessary expertise is a challenging task. In 2023, we were privileged to receive exceptional, timely, and high-quality reviews for the manuscripts submitted for peer evaluation. The Editors give special recognition to the reviewers who went above and beyond what was asked of them, and to recognize their exemplary efforts here. We recognize the individuals listed below (in alphabetical order) for the timeliness and quality of their reviews. Individuals with an asterisk before their name were also recognized as outstanding reviewers in 2022, and those with a dagger were recognized as outstanding reviewers in 2021 and 2022.

Background Cardiovascular events frequently recur after acute myocardial infarction, and low cholesterol efflux — a process mediated by apolipoprotein A1, which is the main protein in high-density lipoprotein — has been associated with an increased risk of cardiovascular events. CSL112 is human apolipoprotein A1 derived from plasma that increases cholesterol efflux capacity. Whether infusions of CSL112 can reduce the risk of recurrent cardiovascular events after acute myocardial infarction is unclear. Methods We conducted an international, double-blind, placebo-controlled trial involving patients with acute myocardial infarction, multivessel coronary artery disease, and additional cardiovascular risk factors. Patients were randomly assigned to receive either four weekly infusions of 6 g of CSL112 or matching placebo, with the first infusion administered within 5 days after the first medical contact for the acute …

BACKGROUNDThe International Atherosclerosis Society (IAS) published an evidence-informed guidance for familial hypercholesterolemia (FH) that provides both clinical and implementation recommendations. We reference examples of strategies from the literature to explore how these implementation recommendations can be tailored into implementation strategies at the local-level for stakeholders guided by a framework proposed by Sarkies and Jones.METHODSFour authors of the IAS guidance selected two published exemplar implementation recommendations for detection, management, and general implementation. Each recommendation was described as an implementation strategy using Proctor's guidance for specifying and reporting implementation strategies. It recommends reporting the actor (who), action (what), action-target (who is impacted), temporality (how often), and dose (how much) for each …

Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic mutations detectable in peripheral blood. The presence of these acquired mutations predisposes otherwise healthy adults to increased risk of several chronic aging-related conditions including hematologic cancers, atherosclerotic cardiovascular diseases, other inflammatory conditions, and mortality. While the public health impact and disease associations of these blood-derived somatic mutations continue to expand, the inherited, behavioral/lifestyle, environmental risk factors and comorbid conditions that influence their occurrence and progression have been less well characterized. Age is the strongest risk factor for all types of CHIP and mCAs. CHIP and mCAs are generally more common in individuals of European than non-European ancestry …

The notion that inflammation contributes to atherosclerosis has now gained considerable currency. Inflammation participates in atherosclerosis inception, progression, and thrombotic complications. Induced expression of endothelial leukocyte adhesion molecules and chemoattractant cytokines recruit blood cells to the arterial intima. Lesions can contain virtually every type of leukocyte. Monocytes mature into macrophages and imbibe lipids becoming foam cells, a hallmark of the atherosclerotic lesion. T lymphocytes can instruct the more numerous macrophages to express genes involved in the progression of the atheroma and its eventual destabilization. Inflammation is becoming clinically actionable to refine risk prediction, allocate treatments, and as a therapeutic target.

Background and Aims Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutations, is associated with atherosclerotic cardiovascular disease and heart failure. This study aimed to test the association of CHIP with new-onset arrhythmias. Methods UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcomes were supraventricular arrhythmias, bradyarrhythmias, and ventricular arrhythmias. Secondary outcomes were cardiac arrest, atrial fibrillation, and any arrhythmia. Associations of any CHIP [variant allele fraction (VAF) ≥ 2%], large CHIP (VAF ≥10%), and gene-specific CHIP subtypes with incident arrhythmias were evaluated using multivariable-adjusted Cox regression. Associations of CHIP with myocardial interstitial fibrosis [T1 measured using cardiac magnetic …