Nadrian C. Seeman
New York University
H-index: 102
North America-United States
Description
Nadrian C. Seeman, With an exceptional h-index of 102 and a recent h-index of 46 (since 2020), a distinguished researcher at New York University, specializes in the field of Structural DNA Nanotechnology.
His recent articles reflect a diverse array of research interests and contributions to the field:
The rule of thirds: controlling junction chirality and polarity in 3D DNA tiles
Toward three-dimensional DNA industrial nanorobots
Programmable 3D hexagonal geometry of DNA tensegrity triangles
Environmentally Controlled Oscillator with Triplex Guided Displacement of DNA Duplexes
Heterobimetallic Base Pair Programming in Designer 3D DNA Crystals
Engineering DNA Crystals toward Studying DNA–Guest Molecule Interactions
Mesojunction-based design paradigm of structural DNA nanotechnology
Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction
Professor Information
University | New York University |
---|---|
Position | ___ |
Citations(all) | 55408 |
Citations(since 2020) | 12492 |
Cited By | 47474 |
hIndex(all) | 102 |
hIndex(since 2020) | 46 |
i10Index(all) | 293 |
i10Index(since 2020) | 150 |
University Profile Page | New York University |
Research & Interests List
Structural DNA Nanotechnology
Top articles of Nadrian C. Seeman
The rule of thirds: controlling junction chirality and polarity in 3D DNA tiles
The successful self‐assembly of tensegrity triangle DNA crystals heralded the ability to programmably construct macroscopic crystalline nanomaterials from rationally‐designed, nanoscale components. This 3D DNA tile owes its “tensegrity” nature to its three rotationally stacked double helices locked together by the tensile winding of a center strand segmented into 7 base pair (bp) inter‐junction regions, corresponding to two‐thirds of a helical turn of DNA. All reported tensegrity triangles to date have employed (Z+2/3)\[\left( {Z{\bm{ + }}2{\bf /}3} \right)\] turn inter‐junction segments, yielding right‐handed, antiparallel, “J1” junctions. Here a minimal DNA triangle motif consisting of 3‐bp inter‐junction segments, or one‐third of a helical turn is reported. It is found that the minimal motif exhibits a reversed morphology with a left‐handed tertiary structure mediated by a locally‐parallel Holliday junction—the “L1” junction. This …
Authors
Simon Vecchioni,Brandon Lu,Jordan Janowski,Karol Woloszyn,Nataša Jonoska,Nadrian C Seeman,Chengde Mao,Yoel P Ohayon,Ruojie Sha
Journal
Small
Published Date
2023/3
Toward three-dimensional DNA industrial nanorobots
Nanoscale industrial robots have potential as manufacturing platforms and are capable of automatically performing repetitive tasks to handle and produce nanomaterials with consistent precision and accuracy. We demonstrate a DNA industrial nanorobot that fabricates a three-dimensional (3D), optically active chiral structure from optically inactive parts. By making use of externally controlled temperature and ultraviolet (UV) light, our programmable robot, ~100 nanometers in size, grabs different parts, positions and aligns them so that they can be welded, releases the construct, and returns to its original configuration ready for its next operation. Our robot can also self-replicate its 3D structure and functions, surpassing single-step templating (restricted to two dimensions) by using folding to access the third dimension and more degrees of freedom. Our introduction of multiple-axis precise folding and positioning as a …
Authors
Feng Zhou,Heng Ni,Guolong Zhu,Lev Bershadsky,Ruojie Sha,Nadrian C Seeman,Paul M Chaikin
Journal
Science Robotics
Published Date
2023/12/6
Programmable 3D hexagonal geometry of DNA tensegrity triangles
Non‐canonical interactions in DNA remain under‐explored in DNA nanotechnology. Recently, many structures with non‐canonical motifs have been discovered, notably a hexagonal arrangement of typically rhombohedral DNA tensegrity triangles that forms through non‐canonical sticky end interactions. Here, we find a series of mechanisms to program a hexagonal arrangement using: the sticky end sequence; triangle edge torsional stress; and crystallization condition. We showcase cross‐talking between Watson–Crick and non‐canonical sticky ends in which the ratio between the two dictates segregation by crystal forms or combination into composite crystals. Finally, we develop a method for reconfiguring the long‐range geometry of formed crystals from rhombohedral to hexagonal and vice versa. These data demonstrate fine control over non‐canonical motifs and their topological self‐assembly. This will vastly …
Authors
Brandon Lu,Karol Woloszyn,Yoel P Ohayon,Bena Yang,Cuizheng Zhang,Chengde Mao,Nadrian C Seeman,Simon Vecchioni,Ruojie Sha
Journal
Angewandte Chemie International Edition
Published Date
2023/2/1
Environmentally Controlled Oscillator with Triplex Guided Displacement of DNA Duplexes
The use of DNA triplex association is advantageous for the reconfiguration of dynamic DNA nanostructures through pH alteration and can provide environmental control for both structural changes and molecular signaling. The combination of pH-induced triplex-forming oligonucleotide (TFOs) binding with toehold-mediated strand displacement has recently garnered significant attention in the field of structural DNA nanotechnology. While most previous studies use single-stranded DNA to displace or replace TFOs within the triplex, here we demonstrate that pH alteration allows a DNA duplex, with a toehold assistance, to displace TFOs from the components of another DNA duplex. We examined the dependence of this process on toehold length and show that the pH changes allow for cyclic oscillations between two molecular formations. We implemented the duplex/triplex design onto the surface of 2D DNA origami in …
Authors
Qiuyan Huang,Jiyeon Kim,Kun Wang,Simon Vecchioni,Yoel P Ohayon,Nadrian C Seeman,Nataša Jonoska,Ruojie Sha
Journal
Nano Letters
Published Date
2023/8/10
Heterobimetallic Base Pair Programming in Designer 3D DNA Crystals
Metal-mediated DNA (mmDNA) presents a pathway toward engineering bioinorganic and electronic behavior into DNA devices. Many chemical and biophysical forces drive the programmable chelation of metals between pyrimidine base pairs. Here, we developed a crystallographic method using the three-dimensional (3D) DNA tensegrity triangle motif to capture single- and multi-metal binding modes across granular changes to environmental pH using anomalous scattering. Leveraging this programmable crystal, we determined 28 biomolecular structures to capture mmDNA reactions. We found that silver(I) binds with increasing occupancy in T–T and U–U pairs at elevated pH levels, and we exploited this to capture silver(I) and mercury(II) within the same base pair and to isolate the titration points for homo- and heterometal base pair modes. We additionally determined the structure of a C–C pair with both silver(I …
Authors
Brandon Lu,Yoel P Ohayon,Karol Woloszyn,Chu-fan Yang,Jesse B Yoder,Lynn J Rothschild,Shalom J Wind,Wayne A Hendrickson,Chengde Mao,Nadrian C Seeman,James W Canary,Ruojie Sha,Simon Vecchioni
Journal
Journal of the American Chemical Society
Published Date
2023/8/2
Engineering DNA Crystals toward Studying DNA–Guest Molecule Interactions
Sequence-selective recognition of DNA duplexes is important for a wide range of applications including regulating gene expression, drug development, and genome editing. Many small molecules can bind DNA duplexes with sequence selectivity. It remains as a challenge how to reliably and conveniently obtain the detailed structural information on DNA–molecule interactions because such information is critically needed for understanding the underlying rules of DNA–molecule interactions. If those rules were understood, we could design molecules to recognize DNA duplexes with a sequence preference and intervene in related biological processes, such as disease treatment. Here, we have demonstrated that DNA crystal engineering is a potential solution. A molecule-binding DNA sequence is engineered to self-assemble into highly ordered DNA crystals. An X-ray crystallographic study of molecule–DNA …
Authors
Cuizheng Zhang,Jiemin Zhao,Brandon Lu,Nadrian C Seeman,Ruojie Sha,Nicholas Noinaj,Chengde Mao
Journal
Journal of the American Chemical Society
Published Date
2023/2/15
Mesojunction-based design paradigm of structural DNA nanotechnology
Mesojunctions were introduced as a basic type of crossover configuration in the early development of structural DNA nanotechnology. However, the investigations of self-assembly from multiple mesojunction complexes have been overlooked in comparison to their counterparts based on regular junctions. In this work, we designed standardized component strands for the construction of complex mesojunction lattices. Three typical mesojunction configurations with three and four arms were showcased in the self-assembly of 1-, 2-, and 3-dimensional lattices constructed from both a scaffold-free tiling approach and a scaffolded origami approach.
Authors
Tianqi Wang,Tanxi Bai,Zhenyu Tan,Yoel P Ohayon,Ruojie Sha,Simon Vecchioni,Nadrian C Seeman,Bryan Wei
Journal
Journal of the American Chemical Society
Published Date
2023/1/19
Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction
DNA double helices containing metal‐mediated DNA (mmDNA) base pairs are constructed from Ag+ and Hg2+ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. Here, the programmability of structural DNA nanotechnology toward its founding mission of self‐assembling a diffraction platform for biomolecular structure determination is explored. The tensegrity triangle is employed to build a comprehensive structural library of mmDNA pairs via X‐ray diffraction and generalized design rules for mmDNA construction are elucidated. Two binding modes are uncovered: N3‐dominant, centrosymmetric pairs and major groove binders driven by 5‐position ring modifications. Energy gap calculations show additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA …
Authors
Simon Vecchioni,Brandon Lu,William Livernois,Yoel P Ohayon,Jesse B Yoder,Chu‐Fan Yang,Karol Woloszyn,William Bernfeld,MP Anantram,James W Canary,Wayne A Hendrickson,Lynn J Rothschild,Chengde Mao,Shalom J Wind,Nadrian C Seeman,Ruojie Sha
Journal
Advanced Materials
Published Date
2023/7
Professor FAQs
What is Nadrian C. Seeman's h-index at New York University?
The h-index of Nadrian C. Seeman has been 46 since 2020 and 102 in total.
What are Nadrian C. Seeman's top articles?
The articles with the titles of
The rule of thirds: controlling junction chirality and polarity in 3D DNA tiles
Toward three-dimensional DNA industrial nanorobots
Programmable 3D hexagonal geometry of DNA tensegrity triangles
Environmentally Controlled Oscillator with Triplex Guided Displacement of DNA Duplexes
Heterobimetallic Base Pair Programming in Designer 3D DNA Crystals
Engineering DNA Crystals toward Studying DNA–Guest Molecule Interactions
Mesojunction-based design paradigm of structural DNA nanotechnology
Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction
...
are the top articles of Nadrian C. Seeman at New York University.
What are Nadrian C. Seeman's research interests?
The research interests of Nadrian C. Seeman are: Structural DNA Nanotechnology
What is Nadrian C. Seeman's total number of citations?
Nadrian C. Seeman has 55,408 citations in total.
What are the co-authors of Nadrian C. Seeman?
The co-authors of Nadrian C. Seeman are Paul M Chaikin, Joel Sussman, Hao Yan, John Reif, Neville R Kallenbach, Thomas H. LaBean.