Mony J. de Leon
Cornell University
H-index: 128
North America-United States
Description
Mony J. de Leon, With an exceptional h-index of 128 and a recent h-index of 74 (since 2020), a distinguished researcher at Cornell University,
His recent articles reflect a diverse array of research interests and contributions to the field:
Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS) to Assess Effects of Age, Sex, and Head Size on Interstitial Fluid Dynamics in Healthy Subjects
Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
Brain Fluid Clearance After Traumatic Brain Injury Measured Using Dynamic Positron Emission Tomography
Between-networks hyperconnectivity is induced by beta-amyloid and may facilitate tau spread
Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of …
Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent
Current understanding of the anatomy, physiology, and magnetic resonance imaging of neurofluids: update from the 2022 “ISMRM Imaging Neurofluids Study group” workshop in Rome
Impaired sleep is associated with tau deposition on 18F-flortaucipir PET and accelerated cognitive decline, accounting for medications that affect sleep
Professor Information
University | Cornell University |
---|---|
Position | Weill Cornell Medicine |
Citations(all) | 75373 |
Citations(since 2020) | 26104 |
Cited By | 55497 |
hIndex(all) | 128 |
hIndex(since 2020) | 74 |
i10Index(all) | 321 |
i10Index(since 2020) | 239 |
University Profile Page | Cornell University |
Top articles of Mony J. de Leon
Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS) to Assess Effects of Age, Sex, and Head Size on Interstitial Fluid Dynamics in Healthy Subjects
Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is a novel MRI method for assessing brain interstitial fluid dynamics, potentially indexing glymphatic function. Failed glymphatic clearance is implicated in Alzheimer’s disease (AD) pathophysiology. We assessed the contribution of age and female sex (strong AD risk factors) to DTI-ALPS index in healthy subjects. We also for the first time assessed the effect of head size. In accord with prior studies, we show reduced DTI-ALPS index with aging, and in men compared to women. However, head size may be a major contributing factor to this counterintuitive sex difference.
Authors
Ilker Ozsahin,Liangdong Zhou,Xiuyuan Wang,Jacob Garetti,Keith Jamison,Ke Xi,Emily Tanzi,Abhishek Jaywant,Abigail Patchell,Thomas Maloney,Mony J de Leon,Amy Kuceyeski,Sudhin A Shah,Yi Li,Tracy A Butler
Journal
Journal of Alzheimer's Disease Reports
Published Date
2024
Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
ImportanceCerebral amyloid angiopathy (CAA) is a common cause of spontaneous intracerebral hemorrhage in older patients. Although other types of intracranial hemorrhage can occur in conjunction with CAA-related intracerebral hemorrhage, the association between CAA and other subtypes of intracranial hemorrhage, particularly in the absence of intracerebral hemorrhage, remains poorly understood.ObjectiveTo determine whether CAA is an independent risk factor for isolated nontraumatic subdural hemorrhage (SDH).Design, Setting, and ParticipantsA population-based cohort study was performed using a 2-stage analysis of prospectively collected data in the UK Biobank cohort (discovery phase, 2006-2022) and the All of Us Research Program cohort (replication phase, 2018-2022). Participants included those who contributed at least 1 year of data while they were older than 50 years, in accordance with the …
Authors
Cyprien A Rivier,Hooman Kamel,Kevin N Sheth,Costantino Iadecola,Ajay Gupta,Mony J de Leon,Elizabeth Ross,Guido J Falcone,Santosh B Murthy
Journal
JAMA neurology
Published Date
2024/2/1
Brain Fluid Clearance After Traumatic Brain Injury Measured Using Dynamic Positron Emission Tomography
Brain fluid clearance by pathways including the recently described paravascular glymphatic system is a critical homeostatic mechanism by which metabolic products, toxins, and other wastes are removed from the brain. Brain fluid clearance may be especially important after traumatic brain injury (TBI), when blood, neuronal debris, inflammatory cells, and other substances can be released and/or deposited. Using a non-invasive dynamic positron emission tomography (PET) method that models the rate at which an intravenously injected radiolabeled molecule (in this case 11C-flumazenil) is cleared from ventricular cerebrospinal fluid (CSF), we estimated the overall efficiency of brain fluid clearance in humans who had experienced complicated-mild or moderate TBI 3–6 months before neuroimaging (n = 7) as compared to healthy controls (n = 9). While there was no significant difference in ventricular clearance …
Authors
Tracy Butler,Julia Schubert,Nikolaos A Karakatsanis,Xiuyuan Hugh Wang,Ke Xi,Yeona Kang,Kewei Chen,Liangdong Zhou,Edward K Fung,Abigail Patchell,Abhishek Jaywant,Yi Li,Gloria Chiang,Lidia Glodzik,Henry Rusinek,Mony de Leon,Federico Turkheimer,Sudhin A Shah
Journal
Neurotrauma Reports
Published Date
2024/4/1
Between-networks hyperconnectivity is induced by beta-amyloid and may facilitate tau spread
Alzheimer's disease (AD) is characterized by the buildup of neurofibrillary tau tangles and beta-amyloid (Aβ) plaques. While it has been hypothesized that Aβ facilitates the spread of tau outside of the medial temporal lobe (MTL), the specific pathological processes and mechanisms by which this occurs remain poorly understood. Our study employed advanced neuroimaging techniques, integrating 18F-Florbetaben Aβ and 18F-MK6240 tau positron emission tomography (PET) with resting-state functional magnetic resonance imaging (rs-fMRI) to characterize these mechanisms in two distinct datasets, that included 481 healthy elderly subjects, 46 of whom came with longitudinal data. Our research highlighted an intricate internetwork relationship between Aβ and tau accumulation, across spatially distinct functional networks. Additionally, we observed compelling evidence supporting the existence of a compensatory mechanism triggered by Aβ accumulation, resulting in hyperconnectivity between functional networks. Finally, the longitudinal findings indicate that between-networks hyperconnectivity is associated with future tau elevation and mediates the relationship between cortical Aβ and early-stage tau. Understanding this early brain alteration in response to the accumulation of Aβ could guide treatments early in the disease course and potentially prevent future tau accumulation.
Authors
Seyed Hani Hojjati,Tracy A Butler,Mony de Leon,Ajay Gupta,Siddharth Nayak,Jose A Luchsinger,Gloria C Chiang,Qolamreza R Razlighi
Journal
medRxiv
Published Date
2024
Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of …
This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age‐related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid‐related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA‐related inflammation (CAA‐ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to …
Authors
Louise Kelly,Christopher Brown,Daniel Michalik,Cheryl A Hawkes,Roxana Aldea,Nivedita Agarwal,Rami Salib,Aiman Alzetani,Douglas W Ethell,Scott E Counts,Mony de Leon,Silvia Fossati,Maya Koronyo‐Hamaoui,Fabrizio Piazza,Steven A Rich,Frank J Wolters,Heather Snyder,Ozama Ismail,Fanny Elahi,Steven T Proulx,Ajay Verma,Hilary Wunderlich,Mareike Haack,Jean Cosme Dodart,Norman Mazer,Roxana O Carare
Published Date
2024/2
Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent
Background: Histopathologic studies of Alzheimer’s disease (AD) suggest that extracellular amyloid-ß (Aß) plaques promote the spread of neurofibrillary tau tangles. However, these two proteinopathies initiate in spatially distinct brain regions, so how they interact during AD progression is unclear.Objective: In this study, we utilized Aß and tau positron emission tomography (PET) scans from 572 older subjects (476 healthy controls (HC), 14 with mild cognitive impairment (MCI), 82 with mild AD), at varying stages of the disease, to investigate to what degree tau is associated with cortical Aß deposition. Methods: Using multiple linear regression models and a pseudo-longitudinal ordering technique, we investigated remote tau-Aß associations in four pathologic phases of AD progression based on tau spread: 1) no-tau, 2) pre-acceleration, 3) acceleration, and 4) post-acceleration.Results: No significant tau-Aß …
Authors
Seyed Hani Hojjati,Gloria C Chiang,Tracy A Butler,Mony de Leon,Ajay Gupta,Yi Li,Mert R Sabuncu,Farnia Feiz,Siddharth Nayak,Jacob Shteingart,Sindy Ozoria,Saman Gholipour Picha,Yaakov Stern,José A Luchsinger,Davangere P Devanand,Qolamreza R Razlighi
Journal
Journal of Alzheimer's Disease
Published Date
2024/3/29
Current understanding of the anatomy, physiology, and magnetic resonance imaging of neurofluids: update from the 2022 “ISMRM Imaging Neurofluids Study group” workshop in Rome
Neurofluids is a term introduced to define all fluids in the brain and spine such as blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily identified the several different fluid environments in the brain and spine that interact in a synchronized harmonious manner to assure a healthy microenvironment required for optimal neuroglial function. Neuroanatomists and biochemists have provided an incredible wealth of evidence revealing the anatomy of perivascular spaces, meninges and glia and their role in drainage of neuronal waste products. Human studies have been limited due to the restricted availability of noninvasive imaging modalities that can provide a high spatiotemporal depiction of the brain neurofluids. Therefore, animal studies have been key in advancing our knowledge of the temporal and spatial dynamics of fluids, for example, by injecting tracers with different …
Authors
Nivedita Agarwal,Laura D Lewis,Lydiane Hirschler,Leonardo Rivera Rivera,Shinji Naganawa,Swati Rane Levendovszky,Geir Ringstad,Marijan Klarica,Joanna Wardlaw,Costantino Iadecola,Cheryl Hawkes,Roxana Octavia Carare,Jack Wells,Erik NTP Bakker,Vartan Kurtcuoglu,Lynne Bilston,Maiken Nedergaard,Yuki Mori,Marcus Stoodley,Noam Alperin,Mony de Leon,Matthias JP van Osch
Published Date
2024/2
Impaired sleep is associated with tau deposition on 18F-flortaucipir PET and accelerated cognitive decline, accounting for medications that affect sleep
BackgroundImpaired sleep is commonly associated with Alzheimer's disease (AD), although the underlying mechanisms remain unclear. Furthermore, the moderating effects of sleep-affecting medications, which have been linked to AD pathology, are incompletely characterized. Using data from the Alzheimer's Disease Neuroimaging Initiative, we investigated whether a medical history of impaired sleep, informant-reported nighttime behaviors, and sleep-affecting medications are associated with beta-amyloid and tau deposition on PET and cognitive change, cross-sectionally and longitudinally.MethodsWe included 964 subjects with 18F-florbetapir PET scans. Measures of sleep impairment and medication use were obtained from medical histories and the Neuropsychiatric Inventory Questionnaire. Multivariate models, adjusted for covariates, were used to assess associations among sleep-related features, beta …
Authors
Ryan T Kim,Liangdong Zhou,Yi Li,Ana C Krieger,Anna S Nordvig,Tracy Butler,Mony J de Leon,Gloria C Chiang,Alzheimer's Disease Neuroimaging Initiative
Journal
Journal of the Neurological Sciences
Published Date
2024/3/15
Professor FAQs
What is Mony J. de Leon's h-index at Cornell University?
The h-index of Mony J. de Leon has been 74 since 2020 and 128 in total.
What are Mony J. de Leon's top articles?
The articles with the titles of
Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS) to Assess Effects of Age, Sex, and Head Size on Interstitial Fluid Dynamics in Healthy Subjects
Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
Brain Fluid Clearance After Traumatic Brain Injury Measured Using Dynamic Positron Emission Tomography
Between-networks hyperconnectivity is induced by beta-amyloid and may facilitate tau spread
Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of …
Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent
Current understanding of the anatomy, physiology, and magnetic resonance imaging of neurofluids: update from the 2022 “ISMRM Imaging Neurofluids Study group” workshop in Rome
Impaired sleep is associated with tau deposition on 18F-flortaucipir PET and accelerated cognitive decline, accounting for medications that affect sleep
...
are the top articles of Mony J. de Leon at Cornell University.
What is Mony J. de Leon's total number of citations?
Mony J. de Leon has 75,373 citations in total.