Michael Phelps
University of California, Los Angeles
H-index: 172
North America-United States
Description
Michael Phelps, With an exceptional h-index of 172 and a recent h-index of 52 (since 2020), a distinguished researcher at University of California, Los Angeles,
His recent articles reflect a diverse array of research interests and contributions to the field:
Application of Annihilation Coincidence Detection to Transaxial Reconstruction Tomography
Remembering Sanjiv (Sam) Gambhir, MD, PhD
Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy
Transforming an academic radiochemistry facility for positron emission tomography drug cGMP compliance
Performance evaluation of microPET: a high-resolution lutetium oxyorthosilicate PET scanner for animal imaging
Professor Information
University | University of California, Los Angeles |
---|---|
Position | ___ |
Citations(all) | 118675 |
Citations(since 2020) | 11939 |
Cited By | 111343 |
hIndex(all) | 172 |
hIndex(since 2020) | 52 |
i10Index(all) | 690 |
i10Index(since 2020) | 253 |
University Profile Page | University of California, Los Angeles |
Top articles of Michael Phelps
Application of Annihilation Coincidence Detection to Transaxial Reconstruction Tomography
A study was carried out to investigate the use of annihilation coincidence detection (ACD) in emission transaxial reconstruction tomography. The ACD was evaluated in terms of spatial resolution and sensitivity with depth, detection efficiency, effect of pulse-height analysis on resolution and efficiency, correction for attenuation, and cold spot contrast. A prototype positron emission transaxial tomograph (PETT) consisting of a hexagonal array of 24 Nal(Tl) detectors employing ACD was constructed. A fast Fourier transform algorithm was employed to generate the reconstructed image. Computer simulations and phantom and animal studies were carried out to demonstrate that this approach yields tomographic radionuclide images that have high resolution and contrast (hot and cold spot) and that are independent of activity above and below the plane examined. The ACD yields a quantitative nuclear medicine imaging …
Authors
Michael E Phelps,Edward J Hoffman,Nizar A Mullani,Michel M Ter-Pogossian
Journal
JOURNAL OF NUCLEAR MEDICINE
Published Date
2020/12/1
Remembering Sanjiv (Sam) Gambhir, MD, PhD
DK Ludwig Professor in Cancer Research, director of the Molecular Imaging Program at Stanford, director of the Canary Center for Cancer Early Detection, and director of the Precision Health and Integrated Diagnostics Center. He authored approximately 700 peer-reviewed articles and 5 books, and he filed 40 patents. Work from his lab has been featured on 36 journal covers. Sam mentored more than 150 postdoctoral and clinical fellows and graduate students, as well as many young faculty in a wide array of disciplines. These individuals benefited from Sam’s inspiring and caring leadership and proudly go on to honor Sam by promulgating his teachings and values. All these activities reflect the immense vision, creativity, energy, ambition, and leadership of Sam as a scholar of international acclaim in molecular imaging, biomedical sciences, medicine, and health care in his relentless desire to do his part to …
Authors
Michael E Phelps,Harvey Herschman
Published Date
2020/9/1
Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy
Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225–labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First, we evaluated the possibility of exploiting IgG3, the IgG subclass with superior activation of complement and ability to mediate FC-γ-receptor binding, for immunotherapeutically enhanced hK2 targeted α-radioimmunotherapy. Second, we compared the therapeutic efficacy of a single high activity vs. fractionated activity. Finally, we used RNA sequencing to analyze the genomic signatures of prostate cancer that progressed after targeted α-therapy. [225Ac]hu11B6-IgG3 was a functionally enhanced alternative to …
Authors
Mesude Bicak,Katharina Lückerath,Teja Kalidindi,Michael E Phelps,Sven-Erik Strand,Michael J Morris,Caius G Radu,Robert Damoiseaux,Mari T Peltola,Norbert Peekhaus,Austin Ho,Darren Veach,Ann-Christin Malmborg Hager,Steven M Larson,Hans Lilja,Michael R McDevitt,Robert J Klein,David Ulmert
Journal
Proceedings of the National Academy of Sciences
Published Date
2020/6/30
Transforming an academic radiochemistry facility for positron emission tomography drug cGMP compliance
In light of the United States Food and Drug Administration (FDA) requirement of 21 CFR 212 current Good Manufacturing Practice (cGMP) for FDA-approved position emission tomography (PET) drugs, the University of California Los Angeles (UCLA) Biomedical Cyclotron (BMC) transformed from a pre-cGMP era academic cyclotron and radiochemistry facility to a current cGMP-compliant PET drug manufacturer. In this article, we share the financial and regulatory compliance aspects of the “transformation” required to develop a sustainable quality system to support the production of two PET drugs under Abbreviated New Drug Applications (ANDAs).
Authors
Shaojun Zhu,Sherly Mosessian,Kurt Kroeger,Saman Sadeghi,Roger Slavik,Simon Kinloch,Melissa Moore,Martin Allen-Auerbach,Johannes Czernin,Michael Phelps
Journal
Molecular Imaging and Biology
Published Date
2020/4
Performance evaluation of microPET: a high-resolution lutetium oxyorthosilicate PET scanner for animal imaging
A new dedicated PET scanner, microPET, was designed and developed at the University of California, Los Angeles, for imaging small laboratory animals. The goal was to provide a compact system with superior spatial resolution at a fraction of the cost of a clinical PET scanner. Methods: The system uses fiberoptic readout of individually cut lutetium oxyorthosilicate (LSO) crystals to achieve high spatial resolution. Each microPET detector consists of an 8 x 8 array of 2 x 2 x 10-mm LSO scintillation crystals that are coupled to a 64-channel photomultiplier tube by optical fibers. The tomograph consists of 30 detectors in a continuous ring with a 17.2-cm diameter and fields of view (FOVs) of 11.25 cm in the transaxial direction and 1.8 cm in the axial direction. The system has eight crystal rings and no interplane septa. It operates exclusively in the three-dimensional mode and has an electronically controlled bed that is …
Authors
Anion F Chatziioannou,Simon R Cherry,Yiping Shao,Robert W Silverman,Ken Meadors,Thomas H Farquhar,Marjan Pedarsani,Michael E Phelps
Journal
JOURNAL OF NUCLEAR MEDICINE
Published Date
2020/12/1
Professor FAQs
What is Michael Phelps's h-index at University of California, Los Angeles?
The h-index of Michael Phelps has been 52 since 2020 and 172 in total.
What are Michael Phelps's top articles?
The articles with the titles of
Application of Annihilation Coincidence Detection to Transaxial Reconstruction Tomography
Remembering Sanjiv (Sam) Gambhir, MD, PhD
Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy
Transforming an academic radiochemistry facility for positron emission tomography drug cGMP compliance
Performance evaluation of microPET: a high-resolution lutetium oxyorthosilicate PET scanner for animal imaging
are the top articles of Michael Phelps at University of California, Los Angeles.
What is Michael Phelps's total number of citations?
Michael Phelps has 118,675 citations in total.