M. Celeste Simon
University of Pennsylvania
H-index: 125
North America-United States
Description
M. Celeste Simon, With an exceptional h-index of 125 and a recent h-index of 75 (since 2020), a distinguished researcher at University of Pennsylvania,
His recent articles reflect a diverse array of research interests and contributions to the field:
RALDH1 inhibition shows immunotherapeutic efficacy in hepatocellular carcinoma
PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance (Retraction of Vol 12 …
Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer
Behavioural evidence for enhanced olfactory and trigeminal perception in congenital hearing loss
A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer
Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy
Cancer Metabolism under Limiting Oxygen Conditions
Retraction Note: PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance
Professor Information
University | University of Pennsylvania |
---|---|
Position | ___ |
Citations(all) | 74477 |
Citations(since 2020) | 23600 |
Cited By | 59566 |
hIndex(all) | 125 |
hIndex(since 2020) | 75 |
i10Index(all) | 278 |
i10Index(since 2020) | 212 |
University Profile Page | University of Pennsylvania |
Top articles of M. Celeste Simon
RALDH1 inhibition shows immunotherapeutic efficacy in hepatocellular carcinoma
Globally, hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers and a leading cause of cancer-related death. We previously identified an immune evasion pathway whereby tumor cells produce retinoic acid (RA) to promote differentiation of intratumoral monocytes into protumor macrophages. Retinaldehyde dehydrogenase 1 (RALDH1), RALDH2, and RALDH3 are the three isozymes that catalyze RA biosynthesis. In this study, we have identified RALDH1 as the key driver of RA production in HCC and demonstrated the efficacy of RALDH1-selective inhibitors (Raldh1-INH) in suppressing RA production by HCC cells. Raldh1-INH restrained tumor growth in multiple mouse models of HCC by reducing the number and tumor-supporting functions of intratumoral macrophages as well as increasing T-cell infiltration and activation within tumors. Raldh1-INH also displayed favorable …
Authors
Pengfei Yu,Shuwen Cao,Shyh-Ming Yang,Ganesha Rai,Natalia J Martinez,Adam Yasgar,Alexey V Zakharov,Anton Simeonov,William A Molina Arocho,Graham P Lobel,Hesham Mohei,Alexis L Scott,Li Zhai,Emma E Furth,M Celeste Simon,Malay Haldar
Journal
Cancer Immunology Research
Published Date
2024/2/2
PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance (Retraction of Vol 12 …
To identify drivers of sarcoma cancer stem-like cells (CSCs), we compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids (which are enriched for CSCs) compared with the parent populations. The most overexpressed survival signaling-related gene in spheroids was phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3), a regulatory subunit of PI3K, which functions in tumorigenesis and metastasis. In a human sarcoma microarray, PIK3R3 was also overexpressed by 4.1-fold compared with normal tissues. PIK3R3 inhibition using shRNA in the HT1080, SK-LMS-1, and DDLS8817 dedifferentiated liposarcoma in spheroids and in CD133+ cells (a CSC marker) reduced expression of CD133 and the stem cell factor Nanog and blocked spheroid formation by 61–71%. Mechanistic studies showed that in spheroid cells, PIK3R3 activated AKT and …
Authors
Changhwan Yoon,Jun Lu,Sandra W Ryeom,M Celeste Simon,Sam S Yoon
Journal
Cell death & disease
Published Date
2021/8
Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer
Availability of the essential amino acid methionine affects cellular metabolism and growth, and dietary methionine restriction has been implicated as a cancer therapeutic strategy. Nevertheless, how liver cancer cells respond to methionine deprivation and underlying mechanisms remain unclear. Here we find that human liver cancer cells undergo irreversible cell cycle arrest upon methionine deprivation in vitro. Blocking methionine adenosyl transferase 2A (MAT2A)-dependent methionine catabolism induces cell cycle arrest and DNA damage in liver cancer cells, resulting in cellular senescence. A pharmacological screen further identified GSK3 inhibitors as senolytics that selectively kill MAT2A-inhibited senescent liver cancer cells. Importantly, combined treatment with MAT2A and GSK3 inhibitors therapeutically blunts liver tumor growth in vitro and in vivo across multiple models. Together, methionine catabolism is …
Authors
Fuming Li,Pingyu Liu,Wen Mi,Liucheng Li,Nicole M Anderson,Nicholas P Lesner,Michelle Burrows,Jacqueline Plesset,Ariana Majer,Guanlin Wang,Jinyang Li,Lingzhi Zhu,Brian Keith,M Celeste Simon
Journal
Nature Cancer
Published Date
2024/1/2
Behavioural evidence for enhanced olfactory and trigeminal perception in congenital hearing loss
Sensory deprivation, especially hearing loss (HL), offers a valuable model for studying neuroplasticity in the human brain and adaptive behaviours that support the daily lives of those with limited or absent sensory input. The study of olfactory function is particularly important as it is an understudied aspect of sensory deprivation. This study aimed to compare the effects of congenital HL on olfactory capacity by using psychophysical tasks. Methodological concerns from previous studies regarding the onset of HL and cognitive assessments were addressed. We recruited 11 individuals with severe‐to‐profound sensorineural HL (SNHL) since birth and 11 age‐ and sex‐matched typical hearing non‐signers. We used standardized neuropsychological tests to assess typical cognition among participants with SNHL. We evaluated olfactory functions by assessing olfactory detection threshold, odour discrimination and odour …
Authors
Catherine Landry,Rim Nazar,Marie Simon,François Genest,Fanny Lécuyer Giguère,Franco Lepore,Johannes Frasnelli
Journal
European Journal of Neuroscience
Published Date
2024/2
A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role in tumor progression and response to therapy. The dense PDAC stroma causes hypovascularity, which leads to hypoxia. Here, we showed that hypoxia drives long-lasting epithelial-mesenchymal transition (EMT) in PDAC primarily through a positive-feedback histone methylation-MAPK signaling axis. Transformed cells preferentially underwent EMT in hypoxic tumor regions in multiple model systems. Hypoxia drove a cell-autonomous EMT in PDAC cells which, unlike EMT in response to growth factors, could last for weeks. Furthermore, hypoxia reduced histone demethylase KDM2A activity, suppressed PP2 family phosphatase expression, and activated MAPKs to post-translationally stabilize histone methyltransferase NSD2, leading to an H3K36me2-dependent EMT in which hypoxia-inducible factors played only a …
Authors
Brooke A Brown,Paul J Myers,Sara J Adair,Jason R Pitarresi,Shiv K Sah-Teli,Logan A Campbell,William S Hart,Michelle C Barbeau,Kelsey Leong,Nicholas Seyler,William Kane,Kyoung Eun Lee,Edward Stelow,Marieke Jones,M Celeste Simon,Peppi Koivunen,Todd W Bauer,Ben Z Stanger,Matthew J Lazzara
Journal
Cancer Research
Published Date
2024/3/12
Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy
Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search PMC Full-Text Archive Search in PMC Advanced Search User Guide Journal List Oncotarget v.15; 2024 PMC10852056 Other Formats PDF (217K) Actions Cite Collections Share Permalink Copy RESOURCES Similar articles Cited by other articles Links to NCBI Databases Journal List Oncotarget v.15; 2024 PMC10852056 As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Logo of oncotarget Oncotarget. …
Authors
Changhwan Yoon,Kevin K Chang,Jun Ho Lee,William D Tap,Charles P Hart,M Celeste Simon,Sam S Yoon
Journal
Oncotarget
Published Date
2024
Cancer Metabolism under Limiting Oxygen Conditions
Molecular oxygen (O2) is essential for cellular bioenergetics and numerous biochemical reactions necessary for life. Solid tumors outgrow the native blood supply and diffusion limits of O2, and therefore must engage hypoxia response pathways that evolved to withstand acute periods of low O2. Hypoxia activates coordinated gene expression programs, primarily through hypoxia inducible factors (HIFs), to support survival. Many of these changes involve metabolic rewiring such as increasing glycolysis to support ATP generation while suppressing mitochondrial metabolism. Since low O2 is often coupled with nutrient stress in the tumor microenvironment, other responses to hypoxia include activation of nutrient uptake pathways, metabolite scavenging, and regulation of stress and growth signaling cascades. Continued development of models that better recapitulate tumors and their microenvironments will lead to …
Authors
Laura C Kim,Nicholas P Lesner,M Celeste Simon
Published Date
2024/2/1
Retraction Note: PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance
● In Fig. 2a, the HT1080 spheroid images appear to have been published in a previous article with common authors [1], where they are described differently.● In Fig. 2b, sh. PIK3R3 panels appear to be the same for both HT1080 Spheroids and SK-LMS-1 Spheroids.● In Supplementary Fig. S2, the panel for invasion monolayer SK-LMS1 in S2a appears to be the same as the panel for invasion+ HT1080 Spheroids in S2d. Further, the panel for Migration Spheroids DDLS8817 in S2a appears to have been previously published in a paper with common authors [2], in which it is described differently.● In Supplementary Fig. S3b, the panel for HT1080 CD133+; LY294002 appears to have been previously published in a paper with common authors [3], where it is described differently.● In Supplementary Fig. S4, HT1080 and SK-LMS-1 panels appear to have been previously published in a paper with common authors …
Authors
Changhwan Yoon,Jun Lu,Sandra W Ryeom,M Celeste Simon,Sam S Yoon
Journal
Cell Death & Disease
Published Date
2024/3
Professor FAQs
What is M. Celeste Simon's h-index at University of Pennsylvania?
The h-index of M. Celeste Simon has been 75 since 2020 and 125 in total.
What are M. Celeste Simon's top articles?
The articles with the titles of
RALDH1 inhibition shows immunotherapeutic efficacy in hepatocellular carcinoma
PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance (Retraction of Vol 12 …
Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer
Behavioural evidence for enhanced olfactory and trigeminal perception in congenital hearing loss
A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer
Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy
Cancer Metabolism under Limiting Oxygen Conditions
Retraction Note: PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance
...
are the top articles of M. Celeste Simon at University of Pennsylvania.
What is M. Celeste Simon's total number of citations?
M. Celeste Simon has 74,477 citations in total.