Lincoln J Ombelets
California Institute of Technology
H-index: 3
North America-United States
About Lincoln J Ombelets
Lincoln J Ombelets, With an exceptional h-index of 3 and a recent h-index of 3 (since 2020), a distinguished researcher at California Institute of Technology, specializes in the field of Data analysis, computational geometry, topology, data visualization.
His recent articles reflect a diverse array of research interests and contributions to the field:
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates
Exploring targeted degradation strategy for oncogenic KRASG12C
Lincoln J Ombelets Information
University | California Institute of Technology |
---|---|
Position | Graduate Student |
Citations(all) | 213 |
Citations(since 2020) | 213 |
Cited By | 59 |
hIndex(all) | 3 |
hIndex(since 2020) | 3 |
i10Index(all) | 2 |
i10Index(since 2020) | 2 |
University Profile Page | California Institute of Technology |
Lincoln J Ombelets Skills & Research Interests
Data analysis
computational geometry
topology
data visualization
Top articles of Lincoln J Ombelets
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Authors
Grace H Hwang,Maria F Pazyra-Murphy,Hyuk-Soo Seo,Sirano Dhe-Paganon,Sylwia A Stopka,Marina DiPiazza,Nizhoni Sutter,Thomas W Gero,Alison Volkert,Lincoln Ombelets,Georgia Dittemore,Matthew G Rees,Melissa M Ronan,Jennifer A Roth,Nathalie YR Agar,David A Scott,Rosalind A Segal
Journal
Cancer Research
Published Date
2024/3/15
Medulloblastoma is one of the most common malignant brain tumors of children, and 30% of medulloblastomas are driven by gain-of-function genetic lesions in the Sonic Hedgehog (SHH) signaling pathway. EYA1, a haloacid dehalogenase phosphatase and transcription factor, is critical for tumorigenesis and proliferation of SHH medulloblastoma (SHH-MB). Benzarone and benzbromarone have been identified as allosteric inhibitors of EYA proteins. Using benzarone as a point of departure, we developed a panel of 35 derivatives and tested them in SHH-MB. Among these compounds, DS-1–38 functioned as an EYA antagonist and opposed SHH signaling. DS-1–38 inhibited SHH-MB growth in vitro and in vivo, showed excellent brain penetrance, and increased the lifespan of genetically engineered mice predisposed to fatal SHH-MB. These data suggest that EYA inhibitors represent promising …
Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates
Published Date
2021/9/28
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Exploring targeted degradation strategy for oncogenic KRASG12C
Authors
Mei Zeng,Yuan Xiong,Nozhat Safaee,Radosław P Nowak,Katherine A Donovan,Christine J Yuan,Behnam Nabet,Thomas W Gero,Frederic Feru,Lianbo Li,Sudershan Gondi,Lincoln J Ombelets,Chunshan Quan,Pasi A Jänne,Milka Kostic,David A Scott,Kenneth D Westover,Eric S Fischer,Nathanael S Gray
Journal
Cell Chemical Biology
Published Date
2020/1/16
KRAS is the most frequently mutated oncogene found in pancreatic, colorectal, and lung cancers. Although it has been challenging to identify targeted therapies for cancers harboring KRAS mutations, KRASG12C can be targeted by small-molecule inhibitors that form covalent bonds with cysteine 12 (C12). Here, we designed a library of C12-directed covalent degrader molecules (PROTACs) and subjected them to a rigorous evaluation process to rapidly identify a lead compound. Our lead degrader successfully engaged CRBN in cells, bound KRASG12C in vitro, induced CRBN/KRASG12C dimerization, and degraded GFP-KRASG12C in reporter cells in a CRBN-dependent manner. However, it failed to degrade endogenous KRASG12C in pancreatic and lung cancer cells. Our data suggest that inability of the lead degrader to effectively poly-ubiquitinate endogenous KRASG12C underlies the lack of activity. We …
Lincoln J Ombelets FAQs
What is Lincoln J Ombelets's h-index at California Institute of Technology?
The h-index of Lincoln J Ombelets has been 3 since 2020 and 3 in total.
What are Lincoln J Ombelets's top articles?
The articles with the titles of
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates
Exploring targeted degradation strategy for oncogenic KRASG12C
are the top articles of Lincoln J Ombelets at California Institute of Technology.
What are Lincoln J Ombelets's research interests?
The research interests of Lincoln J Ombelets are: Data analysis, computational geometry, topology, data visualization
What is Lincoln J Ombelets's total number of citations?
Lincoln J Ombelets has 213 citations in total.