John Blenis
Cornell University
H-index: 118
North America-United States
Description
John Blenis, With an exceptional h-index of 118 and a recent h-index of 66 (since 2020), a distinguished researcher at Cornell University, specializes in the field of cancer signal transduction & metabolism, cancer biology.
His recent articles reflect a diverse array of research interests and contributions to the field:
Decoding Serine Metabolism: Unveiling Novel Pathways for Evolving Cancer Therapies
FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
An atlas of substrate specificities for the human serine/threonine kinome
Cell Biology
LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase
Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism
Balancing lysosome abundance in health and disease
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment
Professor Information
University | Cornell University |
---|---|
Position | Professor of Pharmacology, Weill Cornell Medicine |
Citations(all) | 80594 |
Citations(since 2020) | 17954 |
Cited By | 68561 |
hIndex(all) | 118 |
hIndex(since 2020) | 66 |
i10Index(all) | 221 |
i10Index(since 2020) | 154 |
University Profile Page | Cornell University |
Research & Interests List
cancer signal transduction & metabolism
cancer biology
Top articles of John Blenis
Decoding Serine Metabolism: Unveiling Novel Pathways for Evolving Cancer Therapies
Serine metabolism plays a pivotal role in cancer, making it an appealing therapeutic target. Two recent studies published in Nature Metabolism and Science Translational Medicine uncovered novel players and therapeutic opportunities within this crucial metabolic pathway. Papalazarou and colleagues employed genetic tools coupled with metabolomics and high-throughput imaging to identify and characterize membrane transporters involved in serine uptake and mitochondrial import in colorectal cancer. Notably, they showed that dual inhibition of these transporters in combination with impaired serine biosynthesis reduced tumor growth in xenograft models. In a parallel study, Zhang and colleagues identified isocitrate dehydrogenase I (IDH1) as a novel regulator of serine biosynthesis in non-small cell lung cancer (NSCLC). Through extensive mechanistic studies, they demonstrated that IDH1 enhances the …
Authors
Aristotle Lau,John Blenis,Guillermo Burgos-Barragan
Journal
Cancer Research
Published Date
2024/2/16
FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that stimulates macromolecule synthesis through transcription, RNA processing, and post-translational modification of metabolic enzymes. However, the mechanisms of how mTORC1 orchestrates multiple steps of gene expression programs remain unclear. Here, we identify family with sequence similarity 120A (FAM120A) as a transcription co-activator that couples transcription and splicing of de novo lipid synthesis enzymes downstream of mTORC1-serine/arginine-rich protein kinase 2 (SRPK2) signaling. The mTORC1-activated SRPK2 phosphorylates splicing factor serine/arginine-rich splicing factor 1 (SRSF1), enhancing its binding to FAM120A. FAM120A directly interacts with a lipogenic transcription factor SREBP1 at active promoters, thereby bridging the newly transcribed lipogenic genes from RNA polymerase II to …
Authors
Sungyun Cho,Yujin Chun,Long He,Cuauhtemoc B Ramirez,Kripa S Ganesh,Kyungjo Jeong,Junho Song,Jin Gyu Cheong,Zhongchi Li,Jungmin Choi,Joohwan Kim,Nikos Koundouros,Fangyuan Ding,Noah Dephoure,Cholsoon Jang,John Blenis,Gina Lee
Journal
Molecular Cell
Published Date
2023/8/17
An atlas of substrate specificities for the human serine/threonine kinome
Protein phosphorylation is one of the most widespread post-translational modifications in biology,. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and several thousand have been associated with human diseases and biological processes,. For the vast majority of phosphorylation events, it is not yet known which of the more than 300 protein serine/threonine (Ser/Thr) kinases encoded in the human genome are responsible. Here we used synthetic peptide libraries to profile the substrate sequence specificity of 303 Ser/Thr kinases, comprising more than 84% of those predicted to be active in humans. Viewed in its entirety, the substrate specificity of the kinome was substantially more diverse than expected and was driven extensively by negative selectivity. We used our kinome-wide dataset to computationally annotate …
Authors
Jared L Johnson,Tomer M Yaron,Emily M Huntsman,Alexander Kerelsky,Junho Song,Amit Regev,Ting-Yu Lin,Katarina Liberatore,Daniel M Cizin,Benjamin M Cohen,Neil Vasan,Yilun Ma,Konstantin Krismer,Jaylissa Torres Robles,Bert van de Kooij,Anne E van Vlimmeren,Nicole Andrée-Busch,Norbert F Käufer,Maxim V Dorovkov,Alexey G Ryazanov,Yuichiro Takagi,Edward R Kastenhuber,Marcus D Goncalves,Benjamin D Hopkins,Olivier Elemento,Dylan J Taatjes,Alexandre Maucuer,Akio Yamashita,Alexei Degterev,Mohamed Uduman,Jingyi Lu,Sean D Landry,Bin Zhang,Ian Cossentino,Rune Linding,John Blenis,Peter V Hornbeck,Benjamin E Turk,Michael B Yaffe,Lewis C Cantley
Journal
Nature
Published Date
2023/1/26
Cell Biology
OPEN ACCESS faculty member (Figure 1):(i) first, celebrate both small and significant accomplishments (Figure 1);(ii) second, identify the kinds of opportunities you wish to pursue in the future so that you can develop further relevant skills during your postdoctoral period (Figure 1); and (iii) finally, establish longterm goals to help position your postdoctoral experience into a better perspective. Starting with something as simple as a hand-written goal sheet provides structure to your professional development and can fan the flames of your enthusiasm for a faculty position (Figure 1).Understanding your mentor During your postdoctoral training, it is in your best interest to develop a strong, consistent, and effective communication style with your mentor. Having a mentor who engages with you, whether in a small or big lab, is key to your research success. It also lends itself to advancing your career
Authors
Lindsey Madsen Meservey,Ved V Topkar,Meng-meng Fu
Published Date
2021/6
LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase
The tumor suppressor LKB1 is a serine/threonine protein kinase that is frequently mutated in human lung adenocarcinoma (LUAD). LKB1 regulates a complex signaling network that is known to control cell polarity and metabolism; however, the pathways that mediate the tumor suppressive activity of LKB1 are incompletely defined. To identify mechanisms of LKB1-mediated growth suppression we developed a spheroid-based cell culture assay to study LKB1-dependent growth. Using this assay, along with genome-wide CRISPR screens and validation with orthogonal methods, we discovered that LKB1 suppresses growth, in part, by activating the PIKFYVE lipid kinase, which promotes the internalization of wild-type EGFR. Our findings reveal a new mechanism of regulation of EGFR, which may have implications for the treatment of LKB1-mutant LUAD.
Authors
John Ferrarone,Jerin Thomas,Arun Unni,Yuxiang Zheng,Michal Nagiec,Eric Gardner,Oksana Mashadova,Kate Li,Nikos Koundouros,Antonino Montalbano,Meer Mustafa,Lewis Cantley,John Blenis,Neville Sanjana,Harold Varmus
Journal
bioRxiv
Published Date
2023
Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism
Lysosomes are highly dynamic organelles that rapidly respond to changes in cellular nutrient status. A new study identifies a phosphoinositide switch that dictates lysosome function during nutrient starvation.
Authors
Michal J Nagiec,John Blenis
Journal
Current Biology
Published Date
2023/12/18
Balancing lysosome abundance in health and disease
Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes.
Authors
Anders P Mutvei,Michal J Nagiec,John Blenis
Published Date
2023/9
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment
The role of metabolites exchanged in the tumor microenvironment is largely thought of as fuels to drive the increased biosynthetic and bioenergetic demands of growing tumors. However, this view is shifting as metabolites are increasingly shown to function as signaling molecules that directly regulate oncogenic pathways. Combined with our growing understanding of the essential role of stromal cells, this shift has led to increased interest in how the collective and interconnected metabolome of the tumor microenvironment can drive malignant transformation, epithelial-to-mesenchymal transition, drug resistance, immune evasion, and metastasis. In this review, we discuss how metabolite exchange between tumors and various cell types in the tumor microenvironment—such as fibroblasts, adipocytes, and immune cells—can activate signaling pathways that drive cancer progression.
Authors
Vivien Low,Zhongchi Li,John Blenis
Published Date
2022/11/8
Professor FAQs
What is John Blenis's h-index at Cornell University?
The h-index of John Blenis has been 66 since 2020 and 118 in total.
What are John Blenis's top articles?
The articles with the titles of
Decoding Serine Metabolism: Unveiling Novel Pathways for Evolving Cancer Therapies
FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
An atlas of substrate specificities for the human serine/threonine kinome
Cell Biology
LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase
Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism
Balancing lysosome abundance in health and disease
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment
...
are the top articles of John Blenis at Cornell University.
What are John Blenis's research interests?
The research interests of John Blenis are: cancer signal transduction & metabolism, cancer biology
What is John Blenis's total number of citations?
John Blenis has 80,594 citations in total.