Joao Guimaraes da Costa

A device for cleaning at least a partial region of a housing surface. The device includes a first structure having an outer surface and an inner surface, the outer surface being situated opposite to the inner surface, the inner surface being able to be disposed on the partial region of the housing surface, and a second structure having an outer surface and an inner surface, the outer surface of the second structure being situated opposite to the inner surface of the second structure, wherein the inner surface of the second structure is disposed on the outer surface of the first structure, the first structure being deformable along a first axis by a fluid which is able to be conducted between the first structure and the second structure and the second structure being movable along a second axis, the second axis being disposed perpendicular to the first axis.

This paper shows the simulation and test results of 50 μ m thick Low Gain Avalanche Detectors (LGAD) sensors designed by the Institute of High Energy Physics (IHEP) and fabricated by the Institute of Microelectronics of the Chinese Academy of Sciences (IME). Three wafers have been produced with four different gain layer implant doses each. Different production processes, including variation in the n++ layer implant energy and carbon co-implantation were used. Test results show that the IHEP-IME sensors with the higher dose of gain layer have lower breakdown voltages and higher gain layer voltages from capacitance–voltage properties, which are consistent with the TCAD simulation. Beta test results show that the time resolution of IHEP-IME sensors is better than 35 ps when operated at high voltage and the collected charges of IHEP-IME sensors are larger than 15 fC before irradiation, which fulfill the …

In recent years, three-dimensional (3D) bioprinting has attracted wide research interest in biomedical engineering and clinical applications. This technology allows for unparalleled architecture control, adaptability and repeatability that can overcome the limits of conventional biofabrication techniques. Along with the emergence of a variety of 3D bioprinting methods, bioinks have also come a long way. From their first developments to support bioprinting requirements, they are now engineered to specific injury sites requirements to mimic native tissue characteristics and to support biofunctionality. Current strategies involve the use of bioinks loaded with cells and biomolecules of interest, without altering their functions, to deliver in situ the elements required to enhance healing/regeneration. The current research and trends in bioink development for 3D bioprinting purposes is overviewed herein.

The production cross-section of a top quark in association with a W boson is measured using proton–proton collisions at . The dataset corresponds to an integrated luminosity of , and was collected in 2012 by the ATLAS detector at the Large Hadron Collider at CERN. The analysis is performed in the single-lepton channel. Events are selected by requiring one isolated lepton (electron or muon) and at least three jets. A neural network is trained to separate the tW signal from the dominant background. The cross-section is extracted from a binned profile maximum-likelihood fit to a two-dimensional discriminant built from the neural-network output and the invariant mass of the hadronically decaying W boson. The measured cross-section is , in good agreement with the Standard Model expectation.

MethodsIn this retrospective study, clinical data from patients with diagnose of metastasized NSCLC, treated with pembrolizumab or nivolumab, were collected between June 2015 and January 2020 at the Pulmonology Department of Centro Hospitalar e Universitário São João, Porto, Portugal.ResultsIn a sample of 147 patients, 38 patients (25, 9%) developed irAEs, the majority being grade 1 or 2 (n= 30, 20, 4%). The commonest events were colitis (n= 9, 6, 1%), skin rash (n= 7, 4, 8%) and hyperthyroidism (n= 6, 4, 1%). PFS and OS were statistically higher in the group with irAEs compared to the group of patients without irAEs among patients treated in 1 st line (PFS: 18, 2 months (CI (95%): 5, 0-31, 5) vs. 4, 8 months (CI (95%): 2, 6-6, 9); OS: 20, 2 months (CI (95%): 7, 5-34, 5) vs. 6, 0 months (CI (95%): 3, 4-9, 0)) and in 2 nd line or higher (PFS: 14, 1 months (CI (95%): 10, 1-18, 4) vs. 5, 9 months (CI (95%): 4, 3-7, 6 …

Background Malformations of the central nervous system (CNS) constitute the 2nd most common group of fetal pathologies, which can be reflected throughout the patient's life. Fetal ultrasound (US), together with fetal magnetic resonance imaging (MRI) are extremely important techniques for the diagnosis of CNS malformations. The objective of this work was to address fetal US and fetal MRI, as well as the benefits of its use in different CNS pathologies and to ascertain which of the techniques presents better results. Methods For this systematic literature review, a search was conducted using databases such as PubMed® and ScienceDirect®, Google Scholar, b-on digital library, in a 10-year period, 2010 to 2020. 60 references were used, which met the inclusion criteria, namely compliance with the defined timeframe and the theme of the work to be addressed. Results As for the results, fetal US is the first-line …

Many previous studies have shown a great phylogenetic and biological variability of Trypanosoma cruzi using different molecular and biochemical methods. Populations of T. cruzi were initially clustered into two main lineages called TcI and TcII by the size of the mini‐exon PCR product. In the present study, 33 isolates derived from three triatomine taxa, which belong to the Triatoma brasiliensis species complex (Triatoma juazeirensis, Triatoma melanica and Triatoma sherlocki); collected in three distinct areas of Bahia state were characterized by PCR. The isolates were identified by the size of the mini‐exon gene, 18S rRNA and 24Sα rRNA amplicons. T. cruzi isolates obtained in sylvatic and intradomiciliar ecotopes, derived from T. juazeirensis and T. melanica, were identified as TcI while the parasites originated from T. sherlocki were characterized as TcI and TcII genotypes, respectively. Those species are …

The standard model of particle physics encapsulates our best current understanding of physics at the smallest scales. A fundamental axiom of this theory is the universality of the couplings of the different generations of leptons to the electroweak gauge bosons. The measurement of the ratio of the decay rate of W bosons to τ leptons and muons, R(τ/μ), constitutes an important test of this axiom. Using 139 fb−1 of proton–proton collisions recorded with the ATLAS detector at a centre-of-mass energy of 13 TeV, we report a measurement of this quantity from di-leptonic events where the top quarks decay into a W boson and a bottom quark. We can distinguish muons originating from W bosons and those originating from an intermediate τ lepton through the muon transverse impact parameter and differences in the muon transverse momentum spectra. The measured value of R(τ/μ) is 0.992 ± 0.013 [± 0.007(stat) ± …