Jia Guo
Columbia University in the City of New York
H-index: 6
North America-United States
About Jia Guo
Jia Guo, With an exceptional h-index of 6 and a recent h-index of 6 (since 2020), a distinguished researcher at Columbia University in the City of New York,
His recent articles reflect a diverse array of research interests and contributions to the field:
Cohort Profile: The Mothers and Newborns (MN) Cohort of the Columbia Center for Children’s Environmental Health
Relationship of major depressive disorder and schizophrenia polygenic risk scores to suicide: a comparison between European and Asian ancestry populations
Exploring the overlap between alopecia areata and major depressive disorder: epidemiological and genetic perspectives
Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits
Association of adenosine triphosphate-related genes to major depression and suicidal behavior: Cognition as a potential mediator
Inflammation and mortality in COVID-19 hospitalized patients with and without type 2 diabetes
Association studies of environmental exposures, DNA methylation and children’s cognitive, behavioral, and mental health problems
Prenatal PM2.5 Exposure in Relation to Maternal and Newborn Telomere Length at Delivery
Jia Guo Information
University | Columbia University in the City of New York |
---|---|
Position | Ph.D student Department of Biostatistics |
Citations(all) | 72 |
Citations(since 2020) | 71 |
Cited By | 4 |
hIndex(all) | 6 |
hIndex(since 2020) | 6 |
i10Index(all) | 2 |
i10Index(since 2020) | 2 |
University Profile Page | Columbia University in the City of New York |
Top articles of Jia Guo
Cohort Profile: The Mothers and Newborns (MN) Cohort of the Columbia Center for Children’s Environmental Health
Authors
Kylie W Riley,Jia Guo,Shuang Wang,Pam Factor-Litvak,Rachel L Miller,Howard Andrews,Lori A Hoepner,Amy E Margolis,Virginia Rauh,Andrew Rundle,Frederica Perera,Julie B Herbstman
Journal
International Journal of Epidemiology
Published Date
2024/2/1
The purpose of establishing the Mothers and Newborns (MN) Cohort under the auspices of the Columbia Center for Children’s Environmental Health (CCCEH) was to create a longitudinal birth cohort study that would further the understanding of prenatal and early-life environmental exposures on children’s health outcomes. We specifically wanted to look at these associations in minority populations who are under-represented in research. 1 With this data collection, we intended to further the science of exposure to environmental toxicants on health outcomes including neurodevelopment, asthma and obesity, as well as to inform policy makers of these associations and opportunities to intervene.Women in the MN cohort were recruited from March 1998 through to August 2006 at prenatal ambulatory care clinics of New York Presbyterian Medical Center or Harlem Hospital. These clinics provided care for women who …
Relationship of major depressive disorder and schizophrenia polygenic risk scores to suicide: a comparison between European and Asian ancestry populations
Authors
Ikuo Otsuka,Hanga Galfalvy,Jia Guo,Masato Akiyama,Satoshi Okazaki,Chikashi Terao,Dan Rujescu,Gustavo Turecki,Akitoyo Hishimoto,J John Mann
Journal
Archives of suicide research
Published Date
2024/4/14
Psychiatric diagnosis rates in suicide decedents appear higher in European ancestry populations compared with East Asians. Shared genetic components exist between major depressive disorder (MDD)/schizophrenia (SCZ) and suicide, but no study has compared these shared polygenic architectures between Europeans and East Asians. We compared polygenic risk scores (PRSs) for MDD/SCZ determined from large data sets specific to each ancestry in European and East Asian suicide decedent samples. MDD/SCZ PRSs appeared more prominent in European suicides compared with Japanese suicides. A greater coexistence of psychiatric disorders in European suicide decedents than in East Asian suicide decedents may be partly explained by genetics. Our results are limited by the smaller sample size of our suicide decedents and sample size disparities between the European discovery data set and the …
Exploring the overlap between alopecia areata and major depressive disorder: epidemiological and genetic perspectives
Authors
JC Foo,S Redler,AJ Forstner,FB Basmanav,L Pethukova,J Guo,F Streit,SH Witt,L Sirignano,L Zillich,S Awasthi,S Ripke,AM Christiano,F Tesch,J Schmitt,MM Nöthen,RC Betz,M Rietschel,J Frank
Journal
Journal of the European Academy of Dermatology and Venereology
Published Date
2023/8
Background Research suggests that Alopecia areata (AA) and Major Depressive Disorder (MDD) show substantial comorbidity. To date, no study has investigated the hypothesis that this is attributable to shared genetic aetiology. Objectives To investigate AA‐MDD comorbidity on the epidemiological and molecular genetic levels. Methods First, epidemiological analyses were performed using data from a cohort of adult German health insurance beneficiaries (n = 1.855 million) to determine the population‐based prevalence of AA‐MDD comorbidity. Second, analyses were performed to determine the prevalence of MDD in a clinical AA case–control sample with data on psychiatric phenotypes, stratifying for demographic factors to identify possible contributing factors to AA‐MDD comorbidity. Third, the genetic overlap between AA and MDD was investigated using a polygenic risk score (PRS) approach and linkage …
Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits
Authors
Ikuo Otsuka,Hanga Galfalvy,Jia Guo,Masato Akiyama,Dan Rujescu,Gustavo Turecki,Akitoyo Hishimoto,J John Mann
Journal
Psychological medicine
Published Date
2023/4
Background Suicidal behavior is moderately heritable and a consequence of a combination of the diathesis traits for suicidal behavior and suicide-related major psychiatric disorders. Here, we sought to examine shared polygenic effects between various psychiatric disorders/traits and suicidal behavior and to compare the shared polygenic effects of various psychiatric disorders/traits on non-fatal suicide attempt and suicide death. Methods We used our genotyped European ancestry sample of 260 non-fatal suicide attempters, 317 suicide decedents and 874 non-psychiatric controls to test whether polygenic risk scores (PRSs) obtained from large GWASs for 22 suicide-related psychiatric disorders/traits were associated with suicidal behavior. Results were compared between non-fatal suicide attempt and suicide death in a sensitivity analysis. Results PRSs for major depressive disorder, bipolar disorder …
Association of adenosine triphosphate-related genes to major depression and suicidal behavior: Cognition as a potential mediator
Authors
Shuqiong Zheng,Jia Guo,Qianqian Xin,Hanga Galfalvy,Youran Ye,Na Yan,Rongrong Qian,J John Mann,Enze Li,Xiang Xue,Honglei Yin
Journal
Journal of Affective Disorders
Published Date
2023/2/15
BackgroundSoluble epoxide hydrolase (sEH, encoded by EPHX2) and P2X2 (a subtype of ATP receptors) may mediate the antidepressant-like effects of ATP. We sought to determine whether polymorphisms and mRNA expression of EPHX2 and P2X2 are associated with depression and suicidal behavior and how cognition may mediate such associations.MethodWe examined 83 single nucleotide polymorphisms (SNPs) of EPHX2 and P2X2. Subjects were MDD suicide attempters (N = 143), MDD non-suicide attempters (N = 248), and healthy volunteers (HV, N = 110). Data on demographics, depression severity, and suicide attempts were collected. Participants completed a set of cognitive tasks. Polymorphisms were genotyped using MALDI-TOF MS within the MassARRAY system. The expression of mRNA was measured using real-time polymerase chain reaction (RT-PCR).ResultsCognitive function was a …
Inflammation and mortality in COVID-19 hospitalized patients with and without type 2 diabetes
Authors
Jia Guo,Wen-Hsuan W Lin,Jason E Zucker,Renu Nandakumar,Anne-Catrin Uhlemann,Shuang Wang,Rupak Shivakoti
Journal
The Journal of Clinical Endocrinology & Metabolism
Published Date
2022/5/1
Context COVID-19 mortality is increased in patients with diabetes. A common hypothesis is that the relationship of inflammation with COVID-19 mortality differs by diabetes status. Objective The aim of this study was to determine the relationship of inflammation with mortality in COVID-19 hospitalized patients and to assess if the relationship differs by strata of type 2 diabetes status. Methods A case-control (died-survived) study of 538 COVID-19 hospitalized patients, stratified by diabetes status, was conducted at Columbia University Irving Medical Center. We quantified the levels of 8 cytokines and chemokines in serum, including interferon (IFN)-α2, IFN-γ, interleukin (IL)-1α, IL-1β, IL-6, IL-8/CXCL8, IFNγ-induced protein 10 (IP10)/CXCL10 and tumor necrosis factor α (TNF-α) using immunoassays. Logistic regression models were used to model the …
Association studies of environmental exposures, DNA methylation and children’s cognitive, behavioral, and mental health problems
Authors
Jia Guo,Kylie W Riley,Teresa Durham,Amy E Margolis,Shuang Wang,Frederica Perera,Julie B Herbstman
Journal
Frontiers in Genetics
Published Date
2022/3/31
Introduction: Prenatal environmental exposures have been associated with children’s cognitive, behavioral, and mental health problems, and alterations in DNA methylation have been hypothesized as an underlying biological mechanism. However, when testing this hypothesis, it is often difficult to overcome the problem of multiple comparisons in statistical testing when evaluating a large number of developmental outcomes and DNA methylation sites as potential mediators. The objective of this study is to implement a ‘meet-in-the-middle’ approach with a sequential roadmap to address this concern. Methods: In the Columbia Center for Children’s Environmental Health birth cohort study, we implemented a 5-step sequential process for identifying CpG sites that mediate associations between prenatal environmental exposures and cognitive, behavioral, and mental health problems as measured by the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) and the Child Behavior Checklist (CBCL). These steps include 1) the identification of biological pathways that are relevant to each outcome of interest; 2) selection of a set of genes and CpGs on genes that are significantly associated with the outcomes; 3) identification of exposures that are significantly associated with selected CpGs; 4) examination of exposure-outcome relationships among those where significant CpGs were identified; and 5) mediation analysis of the selected exposures and corresponding outcomes. In this study, we considered a spectrum of environmental exposure classes including environmental phenols, pesticides, phthalates, flame retardants and air pollutants …
Prenatal PM2.5 Exposure in Relation to Maternal and Newborn Telomere Length at Delivery
Authors
Teresa Durham,Jia Guo,Whitney Cowell,Kylie W Riley,Shuang Wang,Deliang Tang,Frederica Perera,Julie B Herbstman
Journal
Toxics
Published Date
2022/1/3
Particulate matter with an aerodynamic diameter of 2.5 μm or less (PM2.5) is a ubiquitous air pollutant that is increasingly threatening the health of adults and children worldwide. One health impact of elevated PM2.5 exposure is alterations in telomere length (TL)—protective caps on chromosome ends that shorten with each cell division. Few analyses involve prenatal PM2.5 exposure, and paired maternal and cord TL measurements. Here, we analyzed the association between average and trimester-specific prenatal PM2.5 exposure, and maternal and newborn relative leukocyte TL measured at birth among 193 mothers and their newborns enrolled in a New-York-City-based birth cohort. Results indicated an overall negative relationship between prenatal PM2.5 and maternal TL at delivery, with a significant association observed in the second trimester (β = −0.039, 95% CI: −0.074, −0.003). PM2.5 exposure in trimester two was also inversely related to cord TL; however, this result did not reach statistical significance (β = −0.037, 95% CI: −0.114, 0.039), and no clear pattern emerged between PM2.5 and cord TL across the different exposure periods. Our analysis contributes to a limited body of research on ambient air pollution and human telomeres, and emphasizes the need for continued investigation into how PM2.5 exposure during pregnancy influences maternal and newborn health.
A methodological pipeline to generate an epigenetic marker of prenatal exposure to air pollution indicators
Authors
Ya Wang,Frederica Perera,Jia Guo,Kylie W Riley,Teresa Durham,Zev Ross,Cande V Ananth,Andrea Baccarelli,Shuang Wang,Julie B Herbstman
Journal
Epigenetics
Published Date
2022/1/2
A barrier in the children’s environmental health field has been the lack of early-warning systems to identify risks of childhood illness and developmental disorders. We aimed to develop a methodology to identify an accessible biomarker measured in a small amount of blood to distinguish newborns at elevated risk from a toxic prenatal exposure, using air pollutants as a case study. Because air pollutants are associated with altered DNA methylation, we developed a pipeline using DNA methylation signatures measured in umbilical cord blood, which could be used as predictors of prenatal exposure. We used air pollution indicators, including modelled trimester-specific and pregnancy average NO2 and PM2.5, and DNA methylation signatures from Illumina arrays measured in two New York City-based longitudinal birth cohorts from the Columbia Centre for Children’s Environmental Health. We developed a screening …
Neighborhood quality and positive health indicators among urban adolescents
Authors
Han N Oo,Miranda Spratlen,Courtney K Blackwell,Teresa Durham,Jia Guo,Lori Hoepner,Diurka Diaz,Gladys Badia,Shuang Wang,Julie B Herbstman
Journal
International Public Health Journal
Published Date
2022/7/1
There is a growing epidemiologic interest to expand the scope of health research beyond disease and risk factors to a more comprehensive evaluation of all health states, including those on the positive end of the spectrum (" positive health"). Neighborhood quality (NQ) is a potentially modifiable factor that may influence positive health. We evaluated the association between perception of NQ in childhood and indicators of positive health among adolescents who live in low-income, urban neighborhoods of New York City. Mothers assessed NQ prospectively via questionnaire at child ages 5, 7, 9, and 11 years. Indicators of positive health domains including general health, physical health, and mental health were assessed and reported by mothers when their children were between the ages of 10-20 years and self-reported among a subset of children at 16-20 years. Children were grouped into" stressed" and" non …
Telomere dynamics across the early life course: Findings from a longitudinal study in children
Authors
Whitney Cowell,Deliang Tang,Jie Yu,Jia Guo,Shuang Wang,Andrea A Baccarelli,Frederica Perera,Julie B Herbstman
Journal
Psychoneuroendocrinology
Published Date
2021/7/1
Telomeres are protective caps on chromosome ends that shorten with each cell division. Telomere length (TL) predicts the onset of cellular senescence and correlates with longevity and age-related disease risk. Previous research suggests that adults display fixed ranking and tracking of TL by age 20 years, supporting the importance of TL at birth and attrition during childhood. However, longitudinal research examining telomere dynamics during early life is sparse. Here, we used monochrome multiplex quantitative polymerase chain reaction to measure relative TL in leukocytes isolated from cord blood and child blood collected at ages 3, 5, 7, and 9 years among 224 minority children enrolled in a New York City-based birth cohort. We also measured maternal TL at delivery in a subset of 197 participants with a biobanked blood sample. TL decreased most rapidly in the first years of life (birth to 3 years), followed by a …
Similarity-based health risk prediction using domain fusion and electronic health records data
Authors
Jia Guo,Chi Yuan,Ning Shang,Tian Zheng,Natalie A Bello,Krzysztof Kiryluk,Chunhua Weng,Shuang Wang
Journal
Journal of Biomedical Informatics
Published Date
2021/4/1
Electronic Health Record (EHR) data represents a valuable resource for individualized prospective prediction of health conditions. Statistical methods have been developed to measure patient similarity using EHR data, mostly using clinical attributes. Only a handful of recent methods have combined clinical analytics with other forms of similarity analytics, and no unified framework exists yet to measure comprehensive patient similarity. Here, we developed a generic framework named Patient similarity based on Domain Fusion (PsDF). PsDF performs patient similarity assessment on each available domain data separately, and then integrate the affinity information over various domains into a comprehensive similarity metric. We used the integrated patient similarity to support outcome prediction by assigning a risk score to each patient. With extensive simulations, we demonstrated that PsDF outperformed existing risk …
Influence of the GABA receptor subunit gene polymorphism and childhood sexual abuse on processing speed in major depression and suicide attempt
Authors
Honglei Yin,Jia Guo,Qianqian Xin,Shuqiong Zheng,Xiang Xue,Enze Li,Ting Liu,Na Yan,John Keilp,J John Mann
Journal
Frontiers in psychiatry
Published Date
2021/10/18
Background: Suicide is moderately heritable and also more common in those who report childhood abuse. Previously, it was found that allele A of GABRG2 (GABA A receptor subunit gamma2) polymorphism rs211034 was protective in a suicide attempt (SA). Hence, it was proposed that rs211034 may interact with childhood trauma to influence cognitive deficits related to SA or depression risk. Genetic variants may predict the benefits of certain cognitive treatments. Methods: A total of 52 individuals who had attempted suicide, 59 individuals with major depressive disorder (MDD) or bipolar depression who had not previously attempted suicide, and 90 healthy volunteers were subjected to the modified Suicide Stroop task and were clinically assessed using the Childhood Trauma Questionnaire (CTQ) and Hamilton Depression Scale-24 items (HAMD-24). rs211034 was genotyped using Sanger sequencing. Results: After correcting for covariates, depressed participants displayed longer reaction times for all emotional conditions, including suicide-related words, compared with healthy controls. Depressed suicide attempters displayed longer reaction times for negative words than depressed non-attempters. Depressed non-attempters displayed higher interference scores for negative words compared with healthy controls. There was an interaction between rs211034 risk allele and the effects of reported childhood sexual abuse (CSA) on reaction time for all emotional words and suicide-related words. Carriers of the rs211034 risk allele A exhibited shorter reaction times, but the protective effects of this allele were eliminated in those exposed to reported …
Jia Guo FAQs
What is Jia Guo's h-index at Columbia University in the City of New York?
The h-index of Jia Guo has been 6 since 2020 and 6 in total.
What are Jia Guo's top articles?
The articles with the titles of
Cohort Profile: The Mothers and Newborns (MN) Cohort of the Columbia Center for Children’s Environmental Health
Relationship of major depressive disorder and schizophrenia polygenic risk scores to suicide: a comparison between European and Asian ancestry populations
Exploring the overlap between alopecia areata and major depressive disorder: epidemiological and genetic perspectives
Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits
Association of adenosine triphosphate-related genes to major depression and suicidal behavior: Cognition as a potential mediator
Inflammation and mortality in COVID-19 hospitalized patients with and without type 2 diabetes
Association studies of environmental exposures, DNA methylation and children’s cognitive, behavioral, and mental health problems
Prenatal PM2.5 Exposure in Relation to Maternal and Newborn Telomere Length at Delivery
...
are the top articles of Jia Guo at Columbia University in the City of New York.
What is Jia Guo's total number of citations?
Jia Guo has 72 citations in total.
What are the co-authors of Jia Guo?
The co-authors of Jia Guo are j. john mann, Frederica Perera, Hanga Galfalvy, Krzysztof Kiryluk, MD, Chunhua Weng.