Foo Yew Liew
University of Glasgow
H-index: 136
Europe-United Kingdom
About Foo Yew Liew
Foo Yew Liew, With an exceptional h-index of 136 and a recent h-index of 52 (since 2020), a distinguished researcher at University of Glasgow, specializes in the field of Immunology, inflammation, infection, nitric oxide, cytokines.
His recent articles reflect a diverse array of research interests and contributions to the field:
Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis
Methods and compositions for treating neurodegenerative and neuroinflammatory conditions
Attenuation of Dupuytren’s fibrosis via targeting of the STAT1 modulated IL-13Rα1 response
Foo Yew Liew Information
University | University of Glasgow |
|---|---|
Position | Gardiner Professor of Immunology UK |
Citations(all) | 60704 |
Citations(since 2020) | 10071 |
Cited By | 54254 |
hIndex(all) | 136 |
hIndex(since 2020) | 52 |
i10Index(all) | 347 |
i10Index(since 2020) | 164 |
University Profile Page | University of Glasgow |
Foo Yew Liew Skills & Research Interests
Immunology
inflammation
infection
nitric oxide
cytokines
Top articles of Foo Yew Liew
Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis
Authors
Paula B Donate,Kalil Alves de Lima,Raphael S Peres,Fausto Almeida,Sandra Y Fukada,Tarcilia A Silva,Daniele C Nascimento,Nerry T Cecilio,Jhimmy Talbot,Rene D Oliveira,Geraldo A Passos,José Carlos Alves-Filho,Thiago M Cunha,Paulo Louzada-Junior,Foo Y Liew,Fernando Q Cunha
Journal
Proceedings of the National Academy of Sciences
Published Date
2021/1/5
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint destruction and severe morbidity. Cigarette smoking (CS) can exacerbate the incidence and severity of RA. Although Th17 cells and the Aryl hydrocarbon receptor (AhR) have been implicated, the mechanism by which CS induces RA development remains unclear. Here, using transcriptomic analysis, we show that microRNA-132 is specifically induced in Th17 cells in the presence of either AhR agonist or CS-enriched medium. miRNA-132 thus induced is packaged into extracellular vesicles produced by Th17 and acts as a proinflammatory mediator increasing osteoclastogenesis through the down-regulation of COX2. In vivo, articular knockdown of miR-132 in murine arthritis models reduces the number of osteoclasts in the joints. Clinically, RA patients express higher levels of miR-132 than do healthy individuals. This increase is …
Methods and compositions for treating neurodegenerative and neuroinflammatory conditions
Published Date
2021/10/28
This invention is generally related to novel compositions and methods for treating or preventing fibrosis, diseases or disorders associated with fibrosis, neurodegeneration, diseases or disorders associated with neurodegeneration and cardiovascular disease or disorders.
Attenuation of Dupuytren’s fibrosis via targeting of the STAT1 modulated IL-13Rα1 response
Authors
Moeed Akbar,Emma Garcia-Melchor,Sabarinadh Chilaka,Kevin J Little,Shatakshi Sood,James H Reilly,Foo Y Liew,Iain B McInnes,Neal L Millar
Journal
Science advances
Published Date
2020/7/10
Fibrotic disorders represent common complex disease pathologies that are therapeutically challenging. Inflammation is associated with numerous fibrotic pathogeneses; however, its role in the multifaceted mechanisms of fibrosis remains unclear. IL-13 is implicated in aberrant responses involved in fibrotic disease, and we aimed to understand its role in the inflammatory processes of a common fibrotic disorder, Dupuytren’s disease. We demonstrated T-cells produced IFN-g, which induced IL-13 secretion from mast cells and up-regulated IL-13Ra1 on fibroblasts, rendering them more reactive to IL-13. Consequently, diseased myofibroblasts demonstrated enhanced fibroproliferative effects upon IL-13 stimulation. We established IFN-g and IL-13 responses involved STAT dependent pathways, and STAT targeting (tofacitinib) could inhibit IL-13 production from mast cells, IL-13Ra1 up-regulation in fibroblasts and …
Foo Yew Liew FAQs
What is Foo Yew Liew's h-index at University of Glasgow?
The h-index of Foo Yew Liew has been 52 since 2020 and 136 in total.
What are Foo Yew Liew's top articles?
The articles with the titles of
Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis
Methods and compositions for treating neurodegenerative and neuroinflammatory conditions
Attenuation of Dupuytren’s fibrosis via targeting of the STAT1 modulated IL-13Rα1 response
are the top articles of Foo Yew Liew at University of Glasgow.
What are Foo Yew Liew's research interests?
The research interests of Foo Yew Liew are: Immunology, inflammation, infection, nitric oxide, cytokines
What is Foo Yew Liew's total number of citations?
Foo Yew Liew has 60,704 citations in total.
Useful Links