Dr. JoAnn E. Manson
Harvard University
H-index: 315
North America-United States
Professor Information
University | Harvard University |
---|---|
Position | Professor of Medicine, Harvard Medical School, Brigham and Womens Hosp, Harvard Sch of Public Health |
Citations(all) | 465003 |
Citations(since 2020) | 130150 |
Cited By | 365402 |
hIndex(all) | 315 |
hIndex(since 2020) | 154 |
i10Index(all) | 1535 |
i10Index(since 2020) | 1279 |
University Profile Page | Harvard University |
Research & Interests List
Endocrinology
Epidemiology
Cardiovascular Disease
Diabetes
Women's health
Top articles of Dr. JoAnn E. Manson
Multidisciplinary approach combining food metabolomics and epidemiology identifies meglutol as an important bioactive metabolite in tempe, an Indonesian fermented food
This study introduces a multidisciplinary approach to investigate bioactive food metabolites often overlooked due to their low concentrations. We integrated an in-house food metabolite library (n = 494), a human metabolite library (n = 891) from epidemiological studies, and metabolite pharmacological databases to screen for food metabolites with potential bioactivity. We identified six potential metabolites, including meglutol (3-hydroxy-3-methylglutarate), an understudied low-density lipoprotein (LDL)-lowering compound. We further focused on meglutol as a case study to showcase the range of characterizations achievable with this approach. Green pea tempe was identified to contain the highest meglutol concentration (21.8 ± 4.6 mg/100 g). Furthermore, we identified a significant cross-sectional association between plasma meglutol and lower LDL cholesterol in two Hispanic adult cohorts (n = 1,628) (β …
Authors
Marvin N Iman,Danielle E Haslam,Liming Liang,Kai Guo,Kaumudi Joshipura,Cynthia M Pérez,Clary Clish,Katherine L Tucker,JoAnn E Manson,Shilpa N Bhupathiraju,Eiichiro Fukusaki,Jessica Lasky-Su,Sastia P Putri
Journal
Food Chemistry
Published Date
2024/2/16
Caregiving and all‐cause mortality in postmenopausal women: Findings from the Women's Health Initiative
Background Caregiving is commonly undertaken by older women. Research is mixed, however, about the impact of prolonged caregiving on their health, well‐being, and mortality risk. Using a prospective study design, we examined the association of caregiving with mortality in a cohort of older women. Methods Participants were 158,987 postmenopausal women aged 50–79 years at enrollment into the Women's Health Initiative (WHI) who provided information on current caregiving status and caregiving frequency at baseline (1993–1998) and follow‐up (2004–2005). Mortality was ascertained from baseline through March of 2019. Cox regression with caregiving status defined as a time‐varying exposure was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for mortality, adjusting for sociodemographic factors, smoking, and history of diabetes, hypertension, cardiovascular disease (CVD …
Authors
Prachi P Chavan,Julie C Weitlauf,Michael J LaMonte,Sue Ann Sisto,Machiko Tomita,Dolores Gallagher‐Thompson,Aladdin H Shadyab,Julie T Bidwell,JoAnn E Manson,Candyce H Kroenke,Kathleen M Hayden,Calvin H Hirsch,Charles P Mouton,Michael B Cannell,Kathleen M Hovey,Jean Wactawski‐Wende
Journal
Journal of the American Geriatrics Society
Published Date
2024/1
Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies
BackgroundA healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity.MethodsIn four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess associations of the signature with mortality and longevity.FindingsThe identified healthy lifestyle metabolomic signature was reflective of lipid …
Authors
Anne-Julie Tessier,Fenglei Wang,Liming Liang,Clemens Wittenbecher,Danielle E Haslam,A Heather Eliassen,Deirdre K Tobias,Jun Li,Oana A Zeleznik,Alberto Ascherio,Qi Sun,Meir J Stampfer,Francine Grodstein,Kathryn M Rexrode,JoAnn E Manson,Raji Balasubramanian,Clary B Clish,Miguel A Martínez-González,Jorge E Chavarro,Frank B Hu,Marta Guasch-Ferré
Journal
Med
Published Date
2024/2/8
Associations of Habitual Calcium Supplementation With Risk of Cardiovascular Disease and Mortality in Individuals With and Without Diabetes
OBJECTIVE To prospectively examine the associations of habitual calcium supplementation with cardiovascular disease (CVD) events and mortality in individuals with and without diabetes. RESEARCH DESIGN AND METHODS The main analysis included 434,374 participants from the UK Biobank. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs. Interactions of calcium supplement use with diabetes status were tested on multiplicative and additive scales. RESULTS Over a median follow-up of 8.1 and 11.2 years, 26,374 incident CVD events and 20,526 deaths were documented, respectively. After multivariable adjustment, habitual calcium supplementation was significantly associated with higher risks of CVD incidence (HR 1.34; 95% CI 1.14, 1.57), CVD mortality (HR 1.67; 95% CI 1.19, 2.33), and all-cause …
Authors
Zixin Qiu,Qi Lu,Zhenzhen Wan,Tingting Geng,Rui Li,Kai Zhu,Lin Li,Xue Chen,An Pan,JoAnn E Manson,Gang Liu
Journal
Diabetes Care
Published Date
2024/2/1
Individual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis …
BackgroundClonal hematopoiesis of indeterminate potential (CHIP), the expansion of leukemogenic mutations in white blood cells, has been associated with increased risk of atherosclerotic cardiovascular diseases, cancer, and mortality.ObjectiveWe examined the relationship between individual- and neighborhood-level socioeconomic status (SES) and CHIP and evaluated effect modification by interpersonal and intrapersonal resources.MethodsThe study population included 10,799 postmenopausal women from the Women's Health Initiative without hematologic malignancy or antineoplastic medication use. Individual- and neighborhood (Census tract)-level SES were assessed across several domains including education, income, and occupation, and a neighborhood-level SES summary z-score, which captures multiple dimensions of SES, was generated. Interpersonal and intrapersonal resources were self …
Authors
Shelly-Ann M Love,Jason M Collins,Kurtis M Anthony,Sophie F Buchheit,Eboneé N Butler,Ganga S Bey,Rahul Gondalia,Kathleen M Hayden,Anthony S Zannas,Alexander G Bick,JoAnn E Manson,Pinkal M Desai,Pradeep Natarajan,Romit Bhattacharya,Siddhartha Jaiswal,Ana Barac,Alex Reiner,Charles Kooperberg,James D Stewart,Eric A Whitsel
Journal
Women's Health Issues
Published Date
2024/3/1
Beverage Consumption, Genetic Predisposition, and Risk of Cardiovascular Disease among Adults with Type 2 Diabetes
Background The evidence regarding the relationship between different types of beverages and cardiovascular health in individuals with type 2 diabetes (T2D) is scarce. Aims To prospectively examine the associations between individual beverage consumption, genetic predisposition, and risk of incident cardiovascular disease (CVD) among adults with T2D. Methods We analyzed the associations of individual beverage intake with risks of CVD and ischemic heart disease (IHD) in 7315 participants with T2D, overall or stratified by genetic risk to CVD, using data from the UK Biobank study. Results During a median follow-up of 6.1 years, 878 incident CVD cases were identified, including 517 IHD cases. Higher intakes of sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and natural juices were each linearly …
Authors
Kai Zhu,Tingting Geng,Zixin Qiu,Rui Li,Lin Li,Ruyi Li,Xue Chen,An Pan,JoAnn E Manson,Gang Liu
Journal
The Journal of Clinical Endocrinology & Metabolism
Published Date
2024/1/27
Lifetime Duration of Breastfeeding and Cardiovascular Risk in Women With Type 2 Diabetes or a History of Gestational Diabetes: Findings From Two Large Prospective Cohorts
OBJECTIVE Breastfeeding duration is inversely associated with risks of cardiovascular disease (CVD) and type 2 diabetes in parous women. However, the association among women at high risk, including women with type 2 diabetes or gestational diabetes (GDM) is unclear. RESEARCH DESIGN AND METHODS We included 15,146 parous women with type 2 diabetes from the Nurses’ Health Study I and II (NHS, NHS II) and 4,537 women with a history of GDM from NHS II. Participants reported history of breastfeeding via follow-up questionnaires. Incident CVD by 2017 comprised stroke or coronary heart disease (CHD: myocardial infarction, coronary revascularization). Adjusted hazard ratios (aHRs) and 95% CIs were estimated using Cox models. RESULTS We documented 1,159 incident CVD cases among women with type 2 diabetes in both cohorts during …
Authors
Anna Birukov,Marta Guasch-Ferré,Sylvia H Ley,Deirdre K Tobias,Fenglei Wang,Clemens Wittenbecher,Jiaxi Yang,JoAnn E Manson,Jorge E Chavarro,Frank B Hu,Cuilin Zhang
Journal
Diabetes Care
Published Date
2024/2/20
Adverse pregnancy outcomes and risk of type 2 diabetes in postmenopausal women
BackgroundAlthough gestational diabetes mellitus and delivering high-birthweight infants are known to predict a higher risk of future type 2 diabetes mellitus, the association of hypertensive disorders of pregnancy and other adverse pregnancy outcomes with type 2 diabetes mellitus is not well established.ObjectiveThis study aimed to examine the associations between different types of adverse pregnancy outcomes and incident type 2 diabetes mellitus among postmenopausal women.Study DesignThe Women’s Health Initiative, a nationwide cohort of postmenopausal women, collected self-reported history of adverse pregnancy outcomes, including gestational diabetes mellitus, hypertensive disorders of pregnancy, preterm birth, and delivering low- birthweight (<2500 g) or high-birthweight (>4500 g) infants. Participants were followed up annually for self-reported incident type 2 diabetes mellitus treated with …
Authors
Kexin Zhu,Jean Wactawski-Wende,Pauline Mendola,Nisha I Parikh,Michael J LaMonte,Vanessa M Barnabei,Rachael Hageman Blair,JoAnn E Manson,Simin Liu,Meng Wang,Robert A Wild,Aladdin H Shadyab,Linda Van Horn,Erin S Leblanc,Rachel Sinkey,Peter F Schnatz,Nazmus Saquib,Lina Mu
Journal
American journal of obstetrics and gynecology
Published Date
2024/1/1
Professor FAQs
What is Dr. JoAnn E. Manson's h-index at Harvard University?
The h-index of Dr. JoAnn E. Manson has been 154 since 2020 and 315 in total.
What are Dr. JoAnn E. Manson's top articles?
The articles with the titles of
Multidisciplinary approach combining food metabolomics and epidemiology identifies meglutol as an important bioactive metabolite in tempe, an Indonesian fermented food
Caregiving and all‐cause mortality in postmenopausal women: Findings from the Women's Health Initiative
Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies
Associations of Habitual Calcium Supplementation With Risk of Cardiovascular Disease and Mortality in Individuals With and Without Diabetes
Individual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis …
Beverage Consumption, Genetic Predisposition, and Risk of Cardiovascular Disease among Adults with Type 2 Diabetes
Lifetime Duration of Breastfeeding and Cardiovascular Risk in Women With Type 2 Diabetes or a History of Gestational Diabetes: Findings From Two Large Prospective Cohorts
Adverse pregnancy outcomes and risk of type 2 diabetes in postmenopausal women
...
are the top articles of Dr. JoAnn E. Manson at Harvard University.
What are Dr. JoAnn E. Manson's research interests?
The research interests of Dr. JoAnn E. Manson are: Endocrinology, Epidemiology, Cardiovascular Disease, Diabetes, Women's health
What is Dr. JoAnn E. Manson's total number of citations?
Dr. JoAnn E. Manson has 465,003 citations in total.