Daniel O. Stram
University of Southern California
H-index: 115
North America-United States
Description
Daniel O. Stram, With an exceptional h-index of 115 and a recent h-index of 58 (since 2020), a distinguished researcher at University of Southern California, specializes in the field of Biostatistics, Genetics, Radiation Epidemiology, Clinical Trials.
His recent articles reflect a diverse array of research interests and contributions to the field:
Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study
Excess pancreatic cancer risk due to smoking and modifying effect of quitting smoking: The Multiethnic Cohort Study
Association of Urinary N7-(1-hydroxyl-3-buten-1-yl) Guanine (EB-GII) Adducts and Butadiene-Mercapturic Acids with Lung Cancer Development in Cigarette Smokers
Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts
Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia
Exposure to outdoor ambient air toxics and risk of breast cancer: The multiethnic cohort
Genome-wide association study of abdominal MRI-measured visceral fat: The multiethnic cohort adiposity phenotype study
Excess risk due to smoking and modifying effect of quitting on bladder cancer incidence: the multiethnic cohort
Professor Information
University | University of Southern California |
---|---|
Position | Professor Biostatistics Division |
Citations(all) | 51354 |
Citations(since 2020) | 15745 |
Cited By | 42635 |
hIndex(all) | 115 |
hIndex(since 2020) | 58 |
i10Index(all) | 382 |
i10Index(since 2020) | 255 |
University Profile Page | University of Southern California |
Research & Interests List
Biostatistics
Genetics
Radiation Epidemiology
Clinical Trials
Top articles of Daniel O. Stram
Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study
Background Ultrafine particles (UFP) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed to assess long-term exposure to airport-related UFPs and lung cancer incidence in a multiethnic population in Los Angeles County. Methods Within the California Multiethnic Cohort, we examined the association between long-term exposure to airport-related UFPs and lung cancer incidence. Multivariable Cox proportional hazards regression models were used to estimate the effect of UFP exposure on lung cancer incidence. Subgroup analyses by demographics, histology and smoking status were conducted. Results Airport-related UFP exposure was not associated with lung cancer risk [per one IGR …
Authors
Arthur Bookstein,Justine Po,Chiuchen Tseng,Timothy V Larson,Juan Yang,Sung-shim L Park,Jun Wu,Salma Shariff-Marco,Pushkar P Inamdar,Ugonna Ihenacho,Veronica W Setiawan,Mindy C DeRouen,Loïc Le Marchand,Daniel O Stram,Jonathan Samet,Beate Ritz,Scott Fruin,Anna H Wu,Iona Cheng
Journal
Cancer Epidemiology, Biomarkers & Prevention
Published Date
2024/3/13
Excess pancreatic cancer risk due to smoking and modifying effect of quitting smoking: The Multiethnic Cohort Study
PurposeRisk factors for pancreatic cancer include racial/ethnic disparities and smoking. However, risk trajectories by smoking history and race/ethnicity are unknown. We examined the association of smoking with pancreatic cancer by race/ethnicity to generate age-specific incidence estimates by smoking history.MethodsWe modeled pancreatic cancer incidence by race/ethnicity, age, pack-years, and years-quit using an excess relative risk model for 182,011 Multiethnic Cohort participants. We tested heterogeneity of smoking variables and pancreatic cancer by race/ethnicity and predicted incidence by smoking history.ResultsWe identified 1,831 incident pancreatic cancer cases over an average 19.3 years of follow-up. Associations of pack-years (p interaction by race/ethnicity = 0.41) and years-quit (p interaction = 0.83) with pancreatic cancer did not differ by race/ethnicity. Fifty pack-years smoked was …
Authors
David Bogumil,Daniel Stram,Dale L Preston,Stephen J Pandol,Anna H Wu,Roberta McKean-Cowdin,David V Conti,Veronica Wendy Setiawan
Journal
Cancer Causes & Control
Published Date
2024/3
Association of Urinary N7-(1-hydroxyl-3-buten-1-yl) Guanine (EB-GII) Adducts and Butadiene-Mercapturic Acids with Lung Cancer Development in Cigarette Smokers
Approximately 10% of smokers will develop lung cancer. Sensitive predictive biomarkers are needed to identify susceptible individuals. 1,3-Butadiene (BD) is among the most abundant tobacco smoke carcinogens. BD is metabolically activated to 3,4-epoxy-1-butene (EB), which is detoxified via the glutathione conjugation/mercapturic acid pathway to form monohydroxybutenyl mercapturic acid (MHBMA) and dihydroxybutyl mercapturic acid (DHBMA). Alternatively, EB can react with guanine nucleobases of DNA to form N7-(1-hydroxyl-3-buten-1-yl) guanine (EB-GII) adducts. We employed isotope dilution LC/ESI-HRMS/MS methodologies to quantify MHBMA, DHBMA, and EB-GII in urine of smokers who developed lung cancer (N = 260) and matched smoking controls (N = 259) from the Southern Community Cohort (white and African American). The concentrations of all three biomarkers were significantly higher in …
Authors
Caitlin C Jokipii Krueger,Sungshim L Park,Yesha Patel,Daniel O Stram,Melinda Aldrich,Qiuyin Cai,Natalia Y Tretyakova
Journal
Chemical Research in Toxicology
Published Date
2024/2/5
Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts
The impact of tobacco exposure on health varies by race and ethnicity and is closely tied to internal nicotine dose, a marker of carcinogen uptake. DNA methylation is strongly responsive to smoking status and may mediate health effects, but study of associations with internal dose is limited. We performed a blood leukocyte epigenome-wide association study (EWAS) of urinary total nicotine equivalents (TNEs; a measure of nicotine uptake) and DNA methylation measured using the MethylationEPIC v1.0 BeadChip (EPIC) in six racial and ethnic groups across three cohort studies. In the Multiethnic Cohort Study (discovery, n = 1994), TNEs were associated with differential methylation at 408 CpG sites across >250 genomic regions (p < 9 × 10−8). The top significant sites were annotated to AHRR, F2RL3, RARA, GPR15, PRSS23, and 2q37.1, all of which had decreasing methylation with increasing TNEs. We identified …
Authors
Brian Z Huang,Alexandra M Binder,Brandon Quon,Yesha M Patel,Annette Lum-Jones,Maarit Tiirikainen,Sharon E Murphy,Lenora Loo,Alika K Maunakea,Christopher A Haiman,Lynne R Wilkens,Woon-Puay Koh,Qiuyin Cai,Melinda C Aldrich,Kimberly D Siegmund,Stephen S Hecht,Jian-Min Yuan,William J Blot,Daniel O Stram,Loïc Le Marchand,Sungshim L Park
Journal
The American Journal of Human Genetics
Published Date
2024/2/12
Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia
Background Expansion of genome-wide association studies across population groups is needed to improve our understanding of shared and unique genetic contributions to breast cancer. We performed association and replication studies guided by a priori linkage findings from African ancestry (AA) relative pairs. Methods We performed fixed-effect inverse-variance weighted meta-analysis under three significant AA breast cancer linkage peaks (3q26-27, 12q22-23, and 16q21-22) in 9241 AA cases and 10 193 AA controls. We examined associations with overall breast cancer as well as estrogen receptor (ER)-positive and negative subtypes (193,132 SNPs). We replicated associations in the African-ancestry Breast Cancer Genetic Consortium (AABCG). Results In AA women, we identified two associations on chr12q for overall breast cancer (rs1420647 …
Authors
Heather M Ochs-Balcom,Leah Preus,Zhaohui Du,Robert C Elston,Craig C Teerlink,Guochong Jia,Xingyi Guo,Qiuyin Cai,Jirong Long,Jie Ping,Bingshan Li,Daniel O Stram,Xiao-Ou Shu,Maureen Sanderson,Guimin Gao,Thomas Ahearn,Kathryn L Lunetta,Gary Zirpoli,Melissa A Troester,Edward A Ruiz-Narváez,Stephen A Haddad,Jonine Figueroa,Esther M John,Leslie Bernstein,Jennifer J Hu,Regina G Ziegler,Sarah Nyante,Elisa V Bandera,Sue A Ingles,Nicholas Mancuso,Michael F Press,Sandra L Deming,Jorge L Rodriguez-Gil,Song Yao,Temidayo O Ogundiran,Oladosu Ojengbede,Manjeet K Bolla,Joe Dennis,Alison M Dunning,Douglas F Easton,Kyriaki Michailidou,Paul DP Pharoah,Dale P Sandler,Jack A Taylor,Qin Wang,Katie M O’Brien,Clarice R Weinberg,Cari M Kitahara,William Blot,Katherine L Nathanson,Anselm Hennis,Barbara Nemesure,Stefan Ambs,Lara E Sucheston-Campbell,Jeannette T Bensen,Stephen J Chanock,Andrew F Olshan,Christine B Ambrosone,Olufunmilayo I Olopade,Ghana Breast Health Study Team,David V Conti,Julie Palmer,Montserrat García-Closas,Dezheng Huo,Wei Zheng,Christopher Haiman
Journal
Human molecular genetics
Published Date
2024/1/23
Exposure to outdoor ambient air toxics and risk of breast cancer: The multiethnic cohort
BackgroundA growing literature has reported associations between traffic-related air pollution and breast cancer, however there are fewer investigations into specific ambient agents and any putative risk of breast cancer development, particularly studies occurring in populations residing in higher pollution areas such as Los Angeles.ObjectivesTo estimate breast cancer risks related to ambient air toxics exposure at residential addresses.MethodsWe examined the relationships between ambient air toxics and breast cancer risk in the Multiethnic Cohort among 48,665 California female participants followed for cancer from 2003 through 2013. We obtained exposure data on chemicals acting as endocrine disruptors or mammary gland carcinogens from the National-Scale Air Toxics Assessment. Cox proportional hazards models were used to estimate breast cancer risk per one interquartile range (IQR) increase in air …
Authors
Julia E Heck,Di He,Sam E Wing,Beate Ritz,Chandra D Carey,Juan Yang,Daniel O Stram,Loïc Le Marchand,Sungshim Lani Park,Iona Cheng,Anna H Wu
Journal
International Journal of Hygiene and Environmental Health
Published Date
2024/6/1
Genome-wide association study of abdominal MRI-measured visceral fat: The multiethnic cohort adiposity phenotype study
Few studies have explored the genetic underpinnings of intra-abdominal visceral fat deposition, which varies substantially by sex and race/ethnicity. Among 1,787 participants in the Multiethnic Cohort (MEC)-Adiposity Phenotype Study (MEC-APS), we conducted a genome-wide association study (GWAS) of the percent visceral adiposity tissue (VAT) area out of the overall abdominal area, averaged across L1-L5 (%VAT), measured by abdominal magnetic resonance imaging (MRI). A genome-wide significant signal was found on chromosome 2q14.3 in the sex-combined GWAS (lead variant rs79837492: Beta per effect allele = -4.76; P = 2.62 × 10−8) and in the male-only GWAS (lead variant rs2968545: (Beta = -6.50; P = 1.09 × 10−9), and one suggestive variant was found at 13q12.11 in the female-only GWAS (rs79926925: Beta = 6.95; P = 8.15 × 10−8). The negatively associated variants were most common in European Americans (T allele of rs79837492; 5%) and African Americans (C allele of rs2968545; 5%) and not observed in Japanese Americans, whereas the positively associated variant was most common in Japanese Americans (C allele of rs79926925, 5%), which was all consistent with the racial/ethnic %VAT differences. In a validation step among UK Biobank participants (N = 23,699 of mainly British and Irish ancestry) with MRI-based VAT volume, both rs79837492 (Beta = -0.026, P = 0.019) and rs2968545 (Beta = -0.028, P = 0.010) were significantly associated in men only (n = 11,524). In the MEC-APS, the association between rs79926925 and plasma sex hormone binding globulin levels reached statistical significance in females …
Authors
Samantha A Streicher,Unhee Lim,S Lani Park,Yuqing Li,Xin Sheng,Victor Hom,Lucy Xia,Loreall Pooler,John Shepherd,Lenora WM Loo,Thomas Ernst,Steven Buchthal,Adrian A Franke,Maarit Tiirikainen,Lynne R Wilkens,Christopher A Haiman,Daniel O Stram,Iona Cheng,Loïc Le Marchand
Journal
Plos one
Published Date
2023/1/6
Excess risk due to smoking and modifying effect of quitting on bladder cancer incidence: the multiethnic cohort
Background: Smoking is an established risk factor for urothelial cancer of the bladder (BC), attributed to over 50% of cases among men, however associations outside of European-descent populations are infrequently reported. Further, absolute risk of BC by smoking history has not yet been reported. Characterizing these associations will identify value of smoking cessation across non-European ancestry populations. Methods: We estimated the association between pack-years, years quit, and BC among 181,231 Multiethnic Cohort Study participants from five major racial/ethnic groups (African Americans [AA], European Americans [EA], Japanese Americans [JA], Latinos [LA], Native Hawaiians [NH]) 45-75 years old at enrollment (1993-1996). Smoking history was assessed by self-report at cohort entry and on a follow-up survey (2003-2008). Associations were estimated using an excess relative risk model to …
Authors
David Bogumil,Victoria Cortessis,Daniel Stram,Veronica W Setiawan,Christopher Haiman,Loic Le Marchand,Gertraud Maskarinec
Journal
Cancer Research
Published Date
2023/4/4
Professor FAQs
What is Daniel O. Stram's h-index at University of Southern California?
The h-index of Daniel O. Stram has been 58 since 2020 and 115 in total.
What are Daniel O. Stram's top articles?
The articles with the titles of
Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study
Excess pancreatic cancer risk due to smoking and modifying effect of quitting smoking: The Multiethnic Cohort Study
Association of Urinary N7-(1-hydroxyl-3-buten-1-yl) Guanine (EB-GII) Adducts and Butadiene-Mercapturic Acids with Lung Cancer Development in Cigarette Smokers
Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts
Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia
Exposure to outdoor ambient air toxics and risk of breast cancer: The multiethnic cohort
Genome-wide association study of abdominal MRI-measured visceral fat: The multiethnic cohort adiposity phenotype study
Excess risk due to smoking and modifying effect of quitting on bladder cancer incidence: the multiethnic cohort
...
are the top articles of Daniel O. Stram at University of Southern California.
What are Daniel O. Stram's research interests?
The research interests of Daniel O. Stram are: Biostatistics, Genetics, Radiation Epidemiology, Clinical Trials
What is Daniel O. Stram's total number of citations?
Daniel O. Stram has 51,354 citations in total.
What are the co-authors of Daniel O. Stram?
The co-authors of Daniel O. Stram are Douglas W Dockery, Nilanjan Chatterjee, Bloomberg Distinguished Professor, Duncan Thomas, Kiros Berhane, Veronica Wendy Setiawan.