Dan Littman
New York University
H-index: 174
North America-United States
Description
Dan Littman, With an exceptional h-index of 174 and a recent h-index of 91 (since 2020), a distinguished researcher at New York University, specializes in the field of immunology, microbiome, inflammation, genomics, transcription.
His recent articles reflect a diverse array of research interests and contributions to the field:
Transmembrane domain–driven PD-1 dimers mediate T cell inhibition
Vasointestinal peptide receptor inhibitors for enhancement of gastrointestinal health
Multimodal single-cell datasets characterize antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection
TH17 cell heterogeneity and its role in tissue inflammation
Niche-specific macrophage loss promotes skin capillary aging
Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes
Il-17 receptor modulator screening system
Professor Information
University | New York University |
---|---|
Position | Skirball Institute, NYU School of Medicine |
Citations(all) | 147644 |
Citations(since 2020) | 40717 |
Cited By | 123446 |
hIndex(all) | 174 |
hIndex(since 2020) | 91 |
i10Index(all) | 351 |
i10Index(since 2020) | 248 |
University Profile Page | New York University |
Research & Interests List
immunology
microbiome
inflammation
genomics
transcription
Top articles of Dan Littman
Transmembrane domain–driven PD-1 dimers mediate T cell inhibition
Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune tolerance. Antagonism of PD-1 signaling has proven effective in cancer immunotherapy, and conversely, agonists of the receptor may have a role in treating autoimmune disease. Some immune receptors function as dimers, but PD-1 has been considered monomeric. Here, we show that PD-1 and its ligands form dimers as a consequence of transmembrane domain interactions and that propensity for dimerization correlates with the ability of PD-1 to inhibit immune responses, antitumor immunity, cytotoxic T cell function, and autoimmune tissue destruction. These observations contribute to our understanding of the PD-1 axis and how it can potentially be manipulated for improved treatment of cancer and autoimmune …
Authors
Elliot A Philips,Jia Liu,Audun Kvalvaag,Alexander M Mørch,Anna S Tocheva,Charles Ng,Hong Liang,Ian M Ahearn,Ruimin Pan,Christina C Luo,Alexander Leithner,Zhihua Qin,Yong Zhou,Antonio Garcia-España,Adam Mor,Dan R Littman,Michael L Dustin,Jun Wang,Xiang-Peng Kong
Journal
Science Immunology
Published Date
2024/3/8
Vasointestinal peptide receptor inhibitors for enhancement of gastrointestinal health
BUTRVBZATBJGPP-BERWWWERSA-N [dp-cl-phe6, leu17]-vip Chemical compound C ([C@@ H](C (= O) N [C@@ H](CC (C) C) C (= O) N [C@@ H](CC (N)= O) C (= O) N [C@@ H](CO) C (= O) N [C@@ H]([C@@ H](C) CC) C (= O) N [C@@ H](CC (C) C) C (= O) N [C@@ H](CC (N)= O) C (N)= O) NC (= O)[C@ H](CCCCN) NC (= O)[C@ H](CCCCN) NC (= O)[C@@ H](NC (= O)[C@ H](C) NC (= O)[C@ H](CC (C) C) NC (= O)[C@ H](CCC (N)= O) NC (= O)[C@ H](CCCCN) NC (= O)[C@ H](CCCNC (N)= N) NC (= O)[C@ H](CC (C) C) NC (= O)[C@ H](CCCNC (N)= N) NC (= O)[C@@ H](NC (= O)[C@ H](CC= 1C= CC (O)= CC= 1) NC (= O)[C@ H](CC (N)= O) NC (= O)[C@ H](CC (O)= O) NC (= O)[C@@ H](NC (= O)[C@@ H](CC= 1C= CC (Cl)= CC= 1) NC (= O)[C@@ H](NC (= O)[C@ H](C) NC (= O)[C@ H](CC (O)= O) NC (= O)[C@ H](CO) NC (= O)[C@@ H](N) CC= 1N= CNC= 1) C (C) C)[C@@ H](C) O)[C@@ H](C) O …
Published Date
2024/3/5
Multimodal single-cell datasets characterize antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection
The immune response to SARS-CoV-2 antigen after infection or vaccination is defined by the durable production of antibodies and T cells. Population-based monitoring typically focuses on antibody titer, but there is a need for improved characterization and quantification of T cell responses. Here, we used multimodal sequencing technologies to perform a longitudinal analysis of circulating human leukocytes collected before and after immunization with the mRNA vaccine BNT162b2. Our data indicated distinct subpopulations of CD8+ T cells, which reliably appeared 28 days after prime vaccination. Using a suite of cross-modality integration tools, we defined their transcriptome, accessible chromatin landscape and immunophenotype, and we identified unique biomarkers within each modality. We further showed that this vaccine-induced population was SARS-CoV-2 antigen-specific and capable of rapid clonal …
Authors
Bingjie Zhang,Rabi Upadhyay,Yuhan Hao,Marie I Samanovic,Ramin S Herati,John D Blair,Jordan Axelrad,Mark J Mulligan,Dan R Littman,Rahul Satija
Journal
Nature immunology
Published Date
2023/10
TH17 cell heterogeneity and its role in tissue inflammation
Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17 cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory disorders. In addition, TH17 cells have been found to play an important role in tissue homeostasis, especially in the intestinal mucosa. Recently, the use of single-cell technologies, along with fate mapping and various mutant mouse models, has led to substantial progress in the understanding of TH17 cell heterogeneity in tissues and of TH17 cell plasticity leading to alternative T cell states and differing functions. In this Review, we discuss the heterogeneity of TH17 cells and the role of this heterogeneity in diverse functions of TH17 cells from homeostasis to tissue inflammation. In addition, we discuss TH17 cell plasticity and its incorporation into the current understanding of T cell subsets and alternative views on the role of TH17 cells …
Authors
Alexandra Schnell,Dan R Littman,Vijay K Kuchroo
Published Date
2023/1
Niche-specific macrophage loss promotes skin capillary aging
All mammalian organs depend upon resident macrophage populations to coordinate repair processes and facilitate tissue-specific functions 1–3. Recent work has established that functionally distinct macrophage populations reside in discrete tissue niches and are replenished through some combination of local proliferation and monocyte recruitment 4, 5. Moreover, decline in macrophage abundance and function in tissues has been shown to contribute to many age-associated pathologies, such as atherosclerosis, cancer, and neurodegeneration 6–8. Despite these advances, the cellular mechanisms that coordinate macrophage organization and replenishment within an aging tissue niche remain largely unknown. Here we show that capillary-associated macrophages (CAMs) are selectively lost over time, which contributes to impaired vascular repair and tissue perfusion in older mice. To investigate resident …
Authors
Kailin R Mesa,Kevin A O’Connor,Charles Ng,Steven P Salvatore,Dan R Littman
Journal
bioRxiv
Published Date
2023/8/27
Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity
Damage to the gastrointestinal tract following allogeneic hematopoietic stem cell transplantation is a significant contributor to the severity and perpetuation of graft-versus-host disease. In preclinical models and clinical trials, we showed that infusing high numbers of regulatory T cells reduces graft-versus-host disease incidence. Despite no change in in vitro suppressive function, transfer of ex vivo expanded regulatory T cells transduced to overexpress G protein–coupled receptor 15 or C-C motif chemokine receptor 9, specific homing receptors for colon or small intestine, respectively, lessened graft-versus-host disease severity in mice. Increased regulatory T cell frequency and retention within the gastrointestinal tissues of mice that received gut homing T cells correlated with lower inflammation and gut damage early post-transplant, decreased graft-versus-host disease severity, and prolonged survival compared with …
Authors
Jemma H Larson,Sujeong Jin,Michael Loschi,Sara Bolivar Wagers,Govindarajan Thangavelu,Michael C Zaiken,Cameron McDonald-Hyman,Asim Saha,Ethan G Aguilar,Brent Koehn,Mark J Osborn,Angela Panoskaltsis-Mortari,Kelli PA Macdonald,Geoffrey R Hill,William J Murphy,Jonathan S Serody,Ivan Maillard,Leslie S Kean,Sangwon V Kim,Dan R Littman,Bruce R Blazar
Journal
American Journal of Transplantation
Published Date
2023/8/1
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes
Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has been implicated in inflammatory conditions, but large-scale metagenomic evaluations have not yet traced the routes by which immunity in the gut affects inflammatory arthritis. To characterize the community structure and associated functional processes driving gut microbial involvement in arthritis, the Inflammatory Arthritis Microbiome Consortium investigated 440 stool shotgun metagenomes comprising 221 adults diagnosed with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis and 219 healthy controls and individuals with joint pain without an underlying inflammatory cause. Diagnosis explained about 2% of gut taxonomic variability, which is comparable in magnitude to inflammatory bowel disease. We identified several candidate microbes with differential carriage patterns in patients with elevated blood markers …
Authors
Kelsey N Thompson,Kevin S Bonham,Nicholas E Ilott,Graham J Britton,Paula Colmenero,Samuel J Bullers,Lauren J McIver,Siyuan Ma,Long H Nguyen,Andrew Filer,India Brough,Claire Pearson,Caroline Moussa,Vinod Kumar,Lilian H Lam,Matthew A Jackson,April Pawluk,Inflammatory Arthritis Microbiome Consortium (IAMC) investigators group,Serafim Kiriakidis,Peter C Taylor,Lucy R Wedderburn,Brian Marsden,Stephen P Young,Dan R Littman,Jeremiah J Faith,Arthur G Pratt,Paul Bowness,Karim Raza,Fiona Powrie,Curtis Huttenhower
Journal
Science Translational Medicine
Published Date
2023/7/26
Il-17 receptor modulator screening system
Provided are compositions and methods for identifying agents that can modulate IL-17 receptors. The compositions and methods use modified cells that produce a detectable signal that indicates whether or not a test agent is an agonist or antagonist of and IL-17 receptor.
Published Date
2023/10/19
Professor FAQs
What is Dan Littman's h-index at New York University?
The h-index of Dan Littman has been 91 since 2020 and 174 in total.
What are Dan Littman's top articles?
The articles with the titles of
Transmembrane domain–driven PD-1 dimers mediate T cell inhibition
Vasointestinal peptide receptor inhibitors for enhancement of gastrointestinal health
Multimodal single-cell datasets characterize antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection
TH17 cell heterogeneity and its role in tissue inflammation
Niche-specific macrophage loss promotes skin capillary aging
Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes
Il-17 receptor modulator screening system
...
are the top articles of Dan Littman at New York University.
What are Dan Littman's research interests?
The research interests of Dan Littman are: immunology, microbiome, inflammation, genomics, transcription
What is Dan Littman's total number of citations?
Dan Littman has 147,644 citations in total.