Costantino Iadecola
Cornell University
H-index: 132
North America-United States
Description
Costantino Iadecola, With an exceptional h-index of 132 and a recent h-index of 77 (since 2020), a distinguished researcher at Cornell University, specializes in the field of cerebral circulation, cerebral ischemia, stroke, Alzheimer's disease, vascular dementia.
His recent articles reflect a diverse array of research interests and contributions to the field:
Abstract TMP74: Association Between Hematoma Volume After Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Infarct‐related structural disconnection and delirium in surgical aortic valve replacement patients
A deeper dive into amyloid clearance by meningeal lymphatic vessels
Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases
Current understanding of the anatomy, physiology, and magnetic resonance imaging of neurofluids: update from the 2022 “ISMRM Imaging Neurofluids Study group” workshop in Rome
Hypertension, Neurodegeneration, and Cognitive Decline
Professor Information
University | Cornell University |
---|---|
Position | Director and Chair, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine |
Citations(all) | 81930 |
Citations(since 2020) | 32067 |
Cited By | 63670 |
hIndex(all) | 132 |
hIndex(since 2020) | 77 |
i10Index(all) | 389 |
i10Index(since 2020) | 289 |
University Profile Page | Cornell University |
Research & Interests List
cerebral circulation
cerebral ischemia
stroke
Alzheimer's disease
vascular dementia
Top articles of Costantino Iadecola
Abstract TMP74: Association Between Hematoma Volume After Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis
Background: Non-traumatic intracerebral hemorrhage (ICH) is independently associated with long-term increased risk of major arterial ischemic events. Whether hematoma volume influences this risk is poorly understood. Methods: We pooled individual patient data from the MISTIE III (Minimally Invasive Surgery Plus Alteplase for Intracerebral Hemorrhage Evacuation phase 3) and the ATACH-2 (Antihypertensive Treatment of Acute Cerebral Hemorrhage) trials. The exposure was hematoma volume. In the primary analysis, hematoma volume was treated as a continuous measure after natural logarithmic transformation to approximate linearity, and in the secondary analysis, it was dichotomized by the median. The outcome was an ischemic stroke, adjudicated centrally within each trial. We evaluated the association between hematoma volume and the risk of an ischemic stroke using Cox regression analyses after …
Authors
William Harris,Jed Kaiser,Radhika Avadhani,Costantino Iadecola,Kevin N Sheth,Issam Awad,Joshua N Goldstein,Adnan I Qureshi,Daniel F Hanley,Hooman Kamel,Wendy C Ziai,Santosh B Murthy
Journal
Stroke
Published Date
2024/2
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairment, the mechanisms of which remain poorly understood. In the present study, in a mouse model of HTN, we find that the neurovascular and cognitive dysfunction depends on interleukin (IL)-17, a cytokine elevated in individuals with HTN. However, neither circulating IL-17 nor brain angiotensin signaling can account for the dysfunction. Rather, IL-17 produced by T cells in the dura mater is the mediator released in the cerebrospinal fluid and activating IL-17 receptors on border-associated macrophages (BAMs). Accordingly, depleting BAMs, deleting IL-17 receptor A in brain macrophages or suppressing meningeal T cells rescues cognitive function without attenuating blood pressure elevation, circulating IL-17 or brain angiotensin signaling. Our data unveil a critical role of meningeal T cells and …
Authors
Monica M Santisteban,Samantha Schaeffer,Antoine Anfray,Giuseppe Faraco,David Brea,Gang Wang,Melissa J Sobanko,Rose Sciortino,Gianfranco Racchumi,Ari Waisman,Laibaik Park,Josef Anrather,Costantino Iadecola
Journal
Nature Neuroscience
Published Date
2024/1
Infarct‐related structural disconnection and delirium in surgical aortic valve replacement patients
Objective Although acute brain infarcts are common after surgical aortic valve replacement (SAVR), they are often unassociated with clinical stroke symptoms. The relationship between clinically “silent” infarcts and in‐hospital delirium remains uncertain; obscured, in part, by how infarcts have been traditionally summarized as global metrics, independent of location or structural consequence. We sought to determine if infarct location and related structural connectivity changes were associated with postoperative delirium after SAVR. Methods A secondary analysis of a randomized multicenter SAVR trial of embolic protection devices (NCT02389894) was conducted, excluding participants with clinical stroke or incomplete neuroimaging (N = 298; 39% female, 7% non‐White, 74 ± 7 years). Delirium during in‐hospital recovery was serially screened using the Confusion Assessment Method. Parcellation and …
Authors
Jeffrey N Browndyke,Lewis E Tomalin,Guray Erus,Jessica R Overbey,Amy Kuceyeski,Alan J Moskowitz,Emilia Bagiella,Alexander Iribarne,Michael Acker,Michael Mack,Joseph Mathew,Patrick O'Gara,Annetine C Gelijns,Mayte Suarez‐Farinas,Steven R Messé,Cardiothoracic Surgical Trials Network (CTSN) Investigators,Kathleen Fenton,Marissa A Miller,Wendy C Taddei‐Peters,Neal O Jeffries,Dennis Buxton,Nancy L Geller,David Gordon,Catherine Burke,Albert Lee,Tyrone Smith,Claudia S Moy,Ilana Kogan Gombos,Marc Gillinov,Mariell Jessup,Richard Weisel,Timothy J Gardner,Eric A Rose,Annetine C Gelijns,Ellen Moquete,Helena L Chang,Melissa Chase,Seth D Goldfarb,Lopa Gupta,Edlira Dobrev,Ron Levitan,Milerva Santos,Xia Ye Michael K Parides,Deborah D Ascheim,Kinjal Shah,Stephanie Pan,Katherine Kirkwood,Karen O'Sullivan,Michael Mack,Rachelle Winkle,Marc Gillinov,Carrie Geither,Michael Argenziano,Sowmya Sreekanth,Jock N McCullough,Henry Stokes,Peter K Smith,Stacey Welsh,Vinod H Thourani,Kim Baio,Pierre Voisine,Gladys Dussault,Mark A Groh,Ralph Mangusan,Robert E Michler,Rebecca Meli,Louis P Perrault,Sophie Robichaud,Keith A Horvath,Margaret Iraola,Bryan A Whitson,Denise Fadorsen,Maral Ouzounian,Shakira Christie,John C Mullen,Alexandra Hripko,James S Gammie,Manal Al‐Suqi,Michael A Acker,Steven Messé,Mary Lou Mayer,Michael Bowdish,Edward Lozano,Gorav Ailawadi,Sandra Burks,David A Bull,Patrice Desvigne‐Nickens,Dennis O Dixon,Rebecca Gottesman,Mark Haigney,Richard Holubkov,Constantino Iadecola,Alice Jacobs,Eric M Meslin,John M Murkin,John A Spertus,Frank Sellke,Cheryl L McDonald,John Canty,Neal Dickert,Dennis O Dixon,John S Ikonomidis,KyungMann Kim,David O Williams,Clyde W Yancy,Seemant Chaturvedi,Marc Chimowitz,James C Fang,Wayne Richenbacher,Vivek Rao,Karen L Furie,Rachel Miller,Jennifer Cook,David D'Alessandro,Frederick Han,Sean Pinney,Mary N Walsh,David Greer,Koto Ishida,Christian Stapf,Judy Hung,Xin Zeng,David Hung,Sudarat Satitthummanid,Michel Billelo,Christos Davatzikos,Guray Erus,Lauren Karpf,Lisa Desiderio,Joseph P Mathew,Jeffrey N Browndyke,Michael L James,Yanne Toulgoat‐Dubois,Rachele Brassard,Renu Virmanu,Maria E Romero,Ryan Braumann
Journal
Annals of Clinical and Translational Neurology
Published Date
2024/2
A deeper dive into amyloid clearance by meningeal lymphatic vessels
Acute depletion of meningeal lymphatic vessels impairs the clearance of cerebrospinal fluid and brain macromolecules. A new study by Antila et al. shows that amyloid pathology in Alzheimer’s disease is neither improved nor aggravated by genetic expansion or depletion of meningeal lymphatic vessels.
Authors
Monica M Santisteban,Costantino Iadecola
Journal
Nature Cardiovascular Research
Published Date
2024/3/15
Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
ImportanceCerebral amyloid angiopathy (CAA) is a common cause of spontaneous intracerebral hemorrhage in older patients. Although other types of intracranial hemorrhage can occur in conjunction with CAA-related intracerebral hemorrhage, the association between CAA and other subtypes of intracranial hemorrhage, particularly in the absence of intracerebral hemorrhage, remains poorly understood.ObjectiveTo determine whether CAA is an independent risk factor for isolated nontraumatic subdural hemorrhage (SDH).Design, Setting, and ParticipantsA population-based cohort study was performed using a 2-stage analysis of prospectively collected data in the UK Biobank cohort (discovery phase, 2006-2022) and the All of Us Research Program cohort (replication phase, 2018-2022). Participants included those who contributed at least 1 year of data while they were older than 50 years, in accordance with the …
Authors
Cyprien A Rivier,Hooman Kamel,Kevin N Sheth,Costantino Iadecola,Ajay Gupta,Mony J de Leon,Elizabeth Ross,Guido J Falcone,Santosh B Murthy
Journal
JAMA neurology
Published Date
2024/2/1
Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases
Ubiquitin modifications alter protein function and stability, thereby regulating cell homeostasis and viability, particularly under stress. Ischemic stroke induces protein ubiquitination at the ischemic periphery, wherein cells remain viable, however the identity of ubiquitinated proteins is unknown. Here, we employed a proteomics approach to identify these proteins in mice undergoing ischemic stroke. The data are available in a searchable web interface (https://hochrainerlab.shinyapps.io/StrokeUbiOmics/). We detected increased ubiquitination of 198 proteins, many of which localize to the postsynaptic density (PSD) of glutamatergic neurons. Among these were proteins essential for maintaining PSD architecture, such as PSD95, as well as NMDA and AMPA receptor subunits. The largest enzymatic group at the PSD with elevated post-ischemic ubiquitination were kinases, such as CaMKII, PKC, Cdk5, and Pyk2, whose …
Authors
Luvna Dhawka,Victoria Palfini,Emma Hambright,Ismary Blanco,Carrie Poon,Anja Kahl,Ulrike Resch,Ruchika Bhawal,Corinne Benakis,Vaishali Balachandran,Alana Holder,Sheng Zhang,Costantino Iadecola,Karin Hochrainer
Journal
Communications Biology
Published Date
2024/3/13
Current understanding of the anatomy, physiology, and magnetic resonance imaging of neurofluids: update from the 2022 “ISMRM Imaging Neurofluids Study group” workshop in Rome
Neurofluids is a term introduced to define all fluids in the brain and spine such as blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily identified the several different fluid environments in the brain and spine that interact in a synchronized harmonious manner to assure a healthy microenvironment required for optimal neuroglial function. Neuroanatomists and biochemists have provided an incredible wealth of evidence revealing the anatomy of perivascular spaces, meninges and glia and their role in drainage of neuronal waste products. Human studies have been limited due to the restricted availability of noninvasive imaging modalities that can provide a high spatiotemporal depiction of the brain neurofluids. Therefore, animal studies have been key in advancing our knowledge of the temporal and spatial dynamics of fluids, for example, by injecting tracers with different …
Authors
Nivedita Agarwal,Laura D Lewis,Lydiane Hirschler,Leonardo Rivera Rivera,Shinji Naganawa,Swati Rane Levendovszky,Geir Ringstad,Marijan Klarica,Joanna Wardlaw,Costantino Iadecola,Cheryl Hawkes,Roxana Octavia Carare,Jack Wells,Erik NTP Bakker,Vartan Kurtcuoglu,Lynne Bilston,Maiken Nedergaard,Yuki Mori,Marcus Stoodley,Noam Alperin,Mony de Leon,Matthias JP van Osch
Published Date
2024/2
Hypertension, Neurodegeneration, and Cognitive Decline
Elevated blood pressure is a well-established risk factor for age-related cognitive decline. Long linked to cognitive impairment on vascular bases, increasing evidence suggests a potential association of hypertension with the neurodegenerative pathology underlying Alzheimer disease. Hypertension is well known to disrupt the structural and functional integrity of the cerebral vasculature. However, the mechanisms by which these alterations lead to brain damage, enhance Alzheimer pathology, and promote cognitive impairment remain to be established. Furthermore, critical questions concerning whether lowering blood pressure by antihypertensive medications prevents cognitive impairment have not been answered. Recent developments in neurovascular biology, brain imaging, and epidemiology, as well as new clinical trials, have provided insights into these critical issues. In particular, clinical and basic findings …
Authors
Anthony Pacholko,Costantino Iadecola
Published Date
2024/3/1
Professor FAQs
What is Costantino Iadecola's h-index at Cornell University?
The h-index of Costantino Iadecola has been 77 since 2020 and 132 in total.
What are Costantino Iadecola's top articles?
The articles with the titles of
Abstract TMP74: Association Between Hematoma Volume After Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Infarct‐related structural disconnection and delirium in surgical aortic valve replacement patients
A deeper dive into amyloid clearance by meningeal lymphatic vessels
Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases
Current understanding of the anatomy, physiology, and magnetic resonance imaging of neurofluids: update from the 2022 “ISMRM Imaging Neurofluids Study group” workshop in Rome
Hypertension, Neurodegeneration, and Cognitive Decline
...
are the top articles of Costantino Iadecola at Cornell University.
What are Costantino Iadecola's research interests?
The research interests of Costantino Iadecola are: cerebral circulation, cerebral ischemia, stroke, Alzheimer's disease, vascular dementia
What is Costantino Iadecola's total number of citations?
Costantino Iadecola has 81,930 citations in total.