Catherine E Barrett

OBJECTIVE To examine the association between diabetes stigma, socioeconomic status, psychosocial variables, and substance use in adolescents and young adults (AYAs) with type 1 or type 2 diabetes. RESEARCH DESIGN AND METHODS This is a cross-sectional analysis of AYAs from the SEARCH for Diabetes in Youth study who completed a survey on diabetes-related stigma, generating a total diabetes stigma score. Using multivariable modeling, stratified by diabetes type, we examined the relationship of diabetes stigma with variables of interest. RESULTS Of the 1,608 AYAs who completed the diabetes-related stigma survey, 78% had type 1 diabetes, and the mean age was 21.7 years. Higher diabetes stigma scores were associated with food insecurity (P = 0.001), disordered eating (P < 0.0001), depressive symptoms (P < 0.0001), and decreased …

The incidence of adolescent mental health disorders is on the rise. Epidemiological studies suggest that poor nutrition is a significant contributor to this public health crisis, specifically through exposure to high level of dietary sugar, including fructose, during critical periods of development. Previous studies have shown that elevated fructose exposure during adolescence disrupts mental health. Despite these data, it is currently unknown how fructose exposure, specifically during infancy, may impact adolescent mental health. We developed a rat experimental protocol to investigate the effects of fructose exposure during infancy on behavioral, cognitive and metabolic endpoints in adolescence. We found that exposing rats to high fructose from birth to weaning resulted in higher circulating glucose, insulin and leptin levels in adolescence. High fructose during infancy also increased bodyweight, disrupted metabolic …

Perceived diabetes stigma (PDS) has been associated with worse clinical and psychosocial outcomes in adults. Our objective was to examine the associations between PDS, glycemic control, diabetes complications, psychosocial variables, and substance use in adolescents and young adults (AYAs) with type 1 diabetes (T1D) and type 2 diabetes (T2D) in the SEARCH for Diabetes in Youth study, 2016-2019. We hypothesized that greater PDS was associated with worse glycemic control, greater frequency of complications, lower use of diabetes technologies, and increased substance use. A 5-question survey was scored on a 6-point Likert scale to generate a total PDS score ranging 5-30. We used diabetes type stratified multivariable modeling to examine variables of interest, adjusting for sex, race/ethnicity, age, location, diabetes duration, education level, health insurance type, treatment regimen, and HbA1c. Of …

We examined the prevalence of diagnosed depression, anxiety, and ADHD among youth by diabetes type, insurance type, and race/ethnicity. These mental disorders were more prevalent among youth with diabetes, particularly those with type 2 diabetes, with non-Hispanic White youth with Medicaid and diabetes having a higher prevalence than other races/ethnicities.

ObjectiveTo assess the association of diabetes and mental, behavioral, and developmental disorders in youth, we examined the magnitude of overlap between these disorders in children and adolescents.Study designIn this cross-sectional study, we calculated prevalence estimates using the 2016–2019 National Survey of Children's Health. Parents reported whether their child was currently diagnosed with diabetes or with any of the following mental, behavioral, or developmental disorders: attention-deficit/hyperactivity disorder, autism spectrum disorder, learning disability, intellectual disability, developmental delay, anxiety, depression, behavioral problems, Tourette syndrome, or speech/language disorder. We present crude prevalence estimates weighted to be representative of the US child population and adjusted prevalence ratios (aPRs) adjusted for age, sex, and race/ethnicity.ResultsAmong children and …

Objective Emerging variants and sublineages of SARS‐CoV‐2 have differing disease severity, transmissibility, and immune evasion. The neurological conditions associated with the original strain of SARS‐CoV‐2 are well established. Our study assessed the neurological presentations specific to hospitalized patients during the B.1.1.529 (Omicron) variant surge in New York City. Methods A total of 178 cases with positive RT‐PCR result within 6 weeks before admission, and subsequent development of select neurological conditions during the SARS‐CoV‐2 B.1.1.529 (Omicron) surge between December 1, 2021 and February 28, 2022, were included from 12,800 SARS‐CoV‐2‐positive hospital admissions. Clinical data from acute hospitalizations were compared to findings of inpatient neurological cases with COVID‐19 infections from the initial surge in NYC in the same hospital system. Results Compared to …

Aims/Hypotheses. People with type 1 (T1D) or type 2 diabetes (T2D) who also have diabetes complications can have pronounced cognitive deficits. It remains unknown, however, whether and how multiple diabetes complications co-occur with cognitive dysfunction, particularly in youth-onset diabetes. Methods. Using data from the SEARCH for Diabetes in Youth Study cohort, a prospective longitudinal cohort, we examined clustering of complications and their underlying clinical factors with performance on cognitive tests in young adults with youth-onset T1D or T2D. Cognition was assessed via the NIH Toolbox Cognition Battery. The main cognitive variables were age-corrected scores for composite fluid cognition and associated cognitive subdomains. Diabetes complications included retinopathy, microalbuminuria, and peripheral neuropathy (PN). Lipids, systolic blood pressure (SBP), hemoglobin A1c, and other clinical factors were included in the analyses. Clustering was applied separately to each group (T1D = 646; T2D = 165). A three-cluster (C) solution was identified for each diabetes type. Mean values and frequencies of all factors were compared between resulting clusters. Results. The average age-corrected score for composite fluid cognition differed significantly across clusters for each group (). People with T1D and the lowest average fluid cognition scores had the highest frequency of self-reporting at least one episode of hypoglycemia in the year preceding cognitive testing and the highest prevalence of PN. Persons with T2D and the lowest average fluid cognition scores had the highest SBP, the highest central systolic and …

OBJECTIVE To examine the association between diabetes stigma and HbA1c, treatment plan and acute and chronic complications in adolescents and young adults (AYAs) with type 1 or type 2 diabetes. RESEARCH DESIGN AND METHODS The SEARCH for Diabetes in Youth study is a multicenter cohort study that collected questionnaire, laboratory, and physical examination data about AYAs with diabetes diagnosed in childhood. A five-question survey assessed frequency of perceived diabetes-related stigma, generating a total diabetes stigma score. We used multivariable linear modeling, stratified by diabetes type, to examine the association of diabetes stigma with clinical factors, adjusting for sociodemographic characteristics, clinic site, diabetes duration, health insurance, treatment plan, and HbA1c. RESULTS Of 1,608 respondents, 78% had type 1 …

SARS-CoV-2 infection is associated with worsening of diabetes symptoms, and persons with diabetes are at increased risk for severe COVID-19. SARS-CoV-2 infection might also induce newly diagnosed diabetes.

Background and ObjectivesThere have been numerous reports of neurologic manifestations identified in hospitalized patients infected with SARS-CoV-2, the virus that causes COVID-19. Here, we identify the spectrum of associated neurologic symptoms and diagnoses, define the time course of their development, and examine readmission rates and mortality risk posthospitalization in a multiethnic urban cohort.MethodsWe identify the occurrence of new neurologic diagnoses among patients with laboratory-confirmed SARS-CoV-2 infection in New York City. A retrospective cohort study was performed on 532 cases (hospitalized patients with new neurologic diagnoses within 6 weeks of positive SARS-CoV-2 laboratory results between March 1, 2020, and August 31, 2020). We compare demographic and clinical features of the 532 cases with 532 controls (hospitalized COVID-19 patients without neurologic …

KELSEY B. EITEL, ALISSA J. ROBERTS, RALPH DAGOSTINO, RONNY A. BELL, ANNA BELLATORRE, CATHERINE E. BARRETT, ANGELICA CRISTELLO, DANA DABELEA, LAWRENCE M. DOLAN, ELIZABETH T. JENSEN, ANGELA D. LIESE, SANTICA M. MARCOVINA, ELIZABETH J. MAYER-DAVIS, KRISTI REYNOLDS, CATHERINE PIHOKER; 597-P: Diabetes Stigma, Sociodemographics, and Psychosocial Outcomes in Adolescents and Young Adults: The SEARCH for Diabetes in Youth Study. Diabetes 1 June 2022; 71 (Supplement_1): 597–P. https://doi. org/10.2337/db22-597-P

ALLISON SHAPIRO, ANNA BELLATORRE, DANA DABELEA, JEANETTE M. STAFFORD, RALPH DAGOSTINO, AMY S. SHAH, ELAINE M. URBINA, CATHERINE E. BARRETT, CATHERINE PIHOKER, SANTICA M. MARCOVINA, ANGELA D. LIESE, AMY K. MOTTL, ELIZABETH T. JENSEN, GRETA WILKENING; 155-OR: Diabetes Complications and Cognitive Function in Youth with Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes 1 June 2021; 70 (Supplement_1): 155–OR. https://doi. org/10.2337/db21-155-OR

Traumatic brain injuries (TBIs) have contributed to approximately one million U.S. deaths during the last 2 decades. Rates of TBIs vary by state. Over the past 20 years, traumatic brain injuries (TBIs) have caused almost a million deaths in the United States. In order to examine the numbers and rates of TBI-related deaths, the percentage difference between each state's rate and the overall U.S. TBI-related death rate, the leading causes of TBI, and the relationship between TBI and a state's level of rurality, the Centers for Disease Control and Prevention (CDC) analyzed National Vital Statistics System (NVSS) mortality data for a 3-year period (2016-2018). In the United States, there were a total of 181,227 TBI-related fatalities from 2016 to 2018 (17.3 per 100,000 people each year). During this time, the percentage gap between state TBI-related death rates and the national rate varied from 46.2% to 101.2% below …

Risk Factors for New Neurological Diagnoses in Hospitalized COVID-19 Patients: A Case-Control Study in New York City (preprint) | ssrn; 2022. | PREPRINT-SSRN المحتوى الرئيسي 1 بحث 2 تذييل 3 +A A -A تباين عالي قاعدة بيانات أبحاث منظمة الصحة العالمية فيروس كورونا (19-COVID) العربية 中文 (中国) english français Русский español português أخبار/تحديث/مساعدة بحث متقدم بحث The WHO Covid-19 Research Database is a resource created in response to the Public Health Emergency of International Concern (PHEIC). Its content remains searchable and spans the time period March 2020 to June 2023. Since June 2023, manual updates to the database have been discontinued. 1.Home - الصفحة الرئيسية 2.بحث 3.Risk Factors for New Neurological Diagnoses in Hospitalized COVID-19 Patients: A Case-Cont This article is a Preprint Preprints are preliminary research reports that have not been certified by peer …

Superhydrophobic-superoleophilic fabrics were prepared and evaluated for oil–water mixture separation efficiencies. The nano-TiO2 and nano-SiO2 based coatings were done on the surface of the cotton fabric to create nanoscale roughness over the surface which was further modified by low energy material 1, 1, 3, 3-Hexamethyldisilazane (HMDS) and, polydimethylsiloxane (PDMS). Particle size and stability of prepared sol were characterized by particle size analysis and zeta potential. Coated cotton fabric samples were characterized by contact angle, contact angle hesteresis and surface free energy for its hydrophobic nature. Surface morphology was studied by scanning electron microscopy (SEM). The coated fabrics were found to be hydrophobic with low surface free energy values. The maximum contact angle was found to be 133 and lowest contact angle hysteresis was 5. SEM confirmed the appearance of nanoscale surface roughness after coating of sols on cotton fabric. The average particle size and zeta potential values of silica sol was 61 nm and 137 mv whereas for titania sol it was found 344 nm and 200 mv, respectively. The oil–water separation efficiency of coated fabric was also observed by a different oil–water mixture. The coatings were found to be hydrophobic in nature and seem to be very useful for oil–water mixture separation.

Tap water that is safe to consume may cause respiratory illness (e.g., Legionnaires’ disease) when water conditions allow for proliferation and aerosolization of biofilm-associated pathogens. This study assessed household tap water consumption, exposure to aerosolized tap water, and associated demographics. A nationally representative FallStyles survey administered by Porter Novelli Public Services was sent to 4,677 US adult panelists in October 2019. There were 3,624 adults who completed the survey (77.5% response rate). Respondents were asked about self-reported use of household tap water for consumption (i.e., drinking, rinsing produce, or making ice) and use through water-aerosolizing devices (e.g., showerheads, humidifiers). Demographics included gender, age, race/ethnicity, education, income, region, and health status. Weighted analyses using complex sample survey procedures were …

Among adults with diabetes, those aged 18–29 years reported the most disruption in access to and use of medical care and the least engagement in prevention of COVID-19, including vaccination intent.

OBJECTIVE To assess whether risk of severe outcomes among patients with type 1 diabetes mellitus (T1DM) hospitalized for coronavirus disease 2019 (COVID-19) differs from that of patients without diabetes or with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS Using the Premier Healthcare Database Special COVID-19 Release records of patients discharged after COVID-19 hospitalization from U.S. hospitals from March to November 2020 (N = 269,674 after exclusion), we estimated risk differences (RD) and risk ratios (RR) of intensive care unit admission or invasive mechanical ventilation (ICU/MV) and of death among patients with T1DM compared with patients without diabetes or with T2DM. Logistic models were adjusted for age, sex, and race or ethnicity. Models adjusted for additional demographic and clinical characteristics were used to examine …

In June 2017, the Pennsylvania Department of Health (PADOH) was notified of multiple norovirus outbreaks associated with 179 ill individuals who attended separate events held at an outdoor venue and campground over a month period. Epidemiologic investigations were unable to identify a single exposure route and therefore unable to determine whether there was a persistent contamination source to target for exposure mitigation. Norovirus was detected in a fresh recreational water designated swimming area and a drinking water well. A hydrogeological site evaluation suggested a nearby septic leach field as a potential contamination source via ground water infiltration. Geological characterization revealed a steep dip of the bedrock beneath the septic leach field toward the well, providing a viral transport pathway in a geologic medium not previously documented as high risk for viral ground water …

Diabetes (DM) is among the most common chronic diseases diagnosed in youth in the United States. In adults, a bi-directional relationship has been demonstrated between DM and mental, behavioral, and developmental disorders (MBDD). Such comorbidities may significantly impact the quality of life of patients with DM and disease management. However, little is known about the association of DM and MBDD in youth. To examine the magnitude of overlap between these chronic conditions, we calculated prevalence estimates using the 2016-2019 National Survey of Children’s Health, an annual, cross-sectional survey of non-institutionalized US children aged 0-17 years (N= 131,774). Parents were asked if their child was ever diagnosed with DM or with any of the following MBDDs: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, learning disability, intellectual disability, developmental …

In an Internet-based survey, approximately 85% of 4,817 US adults reported frequent hand hygiene after contact with public surfaces. Males, young adults, respondents with lower concern about risk for SARS-CoV-2 infection, and respondents without personal COVID-19 experience reported less frequent hand hygiene.

An Internet panel survey identified gaps in knowledge about safe preparation, use, and storage of cleaners and disinfectants. Approximately one third of survey respondents engaged in nonrecommended high-risk practices with the intent of preventing SARS-CoV-2 transmission, including using bleach on food products, applying household cleaning and disinfectant products to skin, and inhaling or ingesting cleaners and disinfectants.

Objectives The objectives of this study were to assess self-reported hygiene precautions taken by U.S. adults during spring 2020 to prevent coronavirus disease 2019 (COVID-19) and to identify demographic characteristics associated with these hygiene precautions. Results We obtained data from Porter Novelli Public Services’s national survey, Spring ConsumerStyles, conducted March 19–April 9, 2020 among a nationally representative random sample of 6463 U.S. adults aged 18 years or older. We present data from the survey question: “What, if any, precautions are you taking to prevent coronavirus?”. Respondents replied yes or no to the following precautions: washing hands often with soap and water and disinfecting surfaces at home and work often. Most respondents reported taking hygiene-related precautions to prevent COVID-19; more respondents reported handwashing (93%) than disinfecting …