Bruce N. AMES

Digital Library at Rajiv Gandhi University: Molecular Cell and Biology Skip navigation DSpace logo Home Browse Communities & Collections Browse Items by: Issue Date Author Title Subject Sign on to: My DSpace Receive email updates Edit Profile Digital Library at Rajiv Gandhi University, Arunachal Pradesh The Digital Library at Rajiv Gandhi University, Arunachal Pradesh is an online emplacement for collecting, preserving, and disseminating the institute's quality teaching research and extension output to the Global community. DSpace logo 1.Digital Library at Rajiv Gandhi University 2.e-Books 3.Basic Sciences 4.Chemistry Please use this identifier to cite or link to this item: http://rguir.inflibnet.ac.in:8080/jspui/handle/123456789/3458 Title: Molecular Cell and Biology Authors: Yates, Kimberly Keywords: Biology Issue Date: 2020 Publisher: S Vermont Ave URI: http://rguir.inflibnet.ac.in:8080/jspui/handle/…

Innovative, creative, and never afraid to plunge into a new research area or express a controversial opinion, Dr. Bruce N. Ames is a brilliant and amazingly productive scientist. His research has covered a remarkable range-from biochemical and genetic analyses of fundamental molecule mechanisms, to designing a widely used test for environmental mutagens and carcinogens, to evaluations of carcinogenic potency, to the studies of the effects of diet on human health and aging. Bruce has published more than 550 papers and is one of the few hundred most-cited scientists in all fields. On the occasion of his 90th birthday, it is an honor to introduce this special issue dedicated to Bruce and his outstanding contributions to science and the scientific community.Bruce was born in 1928 and grew up in New York City. However, it was during summers spent in the Adirondack Mountains that he developed both his …

Ap4 A is perhaps the representative member of the class of molecules known as adenylated dinucleotides. This chapter presents a brief overview of the current knowledge of the metabolism of Ap4 A in prokaryotes, with emphasis on the conclusions which may be drawn from this information, regarding the functions of Ap4 A in bacteria. The synthesis and degradation of Ap4 A in E. coli have been well characterized. Blanquet has demonstrated that an increase in certain aminoacyl tRNA synthetase levels, via increased gene dosage, leads to an increase in the levels of Ap4 A. Ap4 A, normally present in submicromolar concentrations in bacteria, may be induced to much higher levels by a variety of stress conditions. Ap4 A has been implicated in two global stress responses: heat stress and starvation. It has recently been proposed that the signal for heat shock induction is altered “translational capacity” due to damage …

Background Poor diets contribute to metabolic complications of obesity, insulin resistance and dyslipidemia. Metabolomic biomarkers may serve as early nutrition-sensitive health indicators. This family-based lifestyle change program compared metabolic outcomes in an intervention group (INT) that consumed 2 nutrient bars daily for 2-months and a control group (CONT). Methods Overweight, predominantly minority and female adolescent (Teen)/parent adult caretaker (PAC) family units were recruited from a pediatric obesity clinic. CONT (8 Teen, 8 PAC) and INT (10 Teen, 10 PAC) groups randomized to nutrient bar supplementation attended weekly classes that included group nutrition counseling and supervised exercise. Pre-post physical and behavioral parameters, fasting traditional biomarkers, plasma sphingolipids and amino acid metabolites were measured. Results In the full cohort, a baseline sphingolipid ceramide principal component composite score correlated with adiponectin, triglycerides, triglyceride-rich very low density lipoproteins, and atherogenic small low density lipoprotein (LDL) sublasses. Inverse associations were seen between a sphingomyelin composite score and C-reactive protein, a dihydroceramide composite score and diastolic blood pressure, and the final principal component that included glutathionone with fasting insulin and the homeostatic model of insulin resistance. In CONT, plasma ceramides, sphinganine, sphingosine and amino acid metabolites increased, presumably due to increased physical activity. Nutrient bar supplementation (INT) blunted this rise and significantly decreased ureagenic, aromatic …