Preterm birth associated alterations in brain structure, cognitive functioning and behavior in children from the ABCD dataset

Proceedings of the AAAI Conference on Artificial Intelligence

Infrared Small Target Detection (IRSTD) refers to detecting faint targets in infrared images, which has achieved notable progress with the advent of deep learning. However, the drive for improved detection accuracy has led to larger, intricate models with redundant parameters, causing storage and computation inefficiencies. In this pioneering study, we introduce the concept of utilizing network pruning to enhance the efficiency of IRSTD. Due to the challenge posed by low signal-to-noise ratios and the absence of detailed semantic information in infrared images, directly applying existing pruning techniques yields suboptimal performance. To address this, we propose a novel wavelet structure-regularized soft channel pruning method, giving rise to the efficient IRPruneDet model. Our approach involves representing the weight matrix in the wavelet domain and formulating a wavelet channel pruning strategy. We incorporate wavelet regularization to induce structural sparsity without incurring extra memory usage. Moreover, we design a soft channel reconstruction method that preserves important target information against premature pruning, thereby ensuring an optimal sparse structure while maintaining overall sparsity. Through extensive experiments on two widely-used benchmarks, our IRPruneDet method surpasses established techniques in both model complexity and accuracy. Specifically, when employing U-net as the baseline network, IRPruneDet achieves a 64.13% reduction in parameters and a 51.19% decrease in FLOPS, while improving IoU from 73.31% to 75.12% and nIoU from 70.92% to 74.30%. The source code will be released.

IEEE Transactions on Multimedia

Image dehazing is a pivotal preliminary step in the advancement of robust intelligent surveillance system. However, it is an extremely challenging ill-posed problem, as it faces severe information degradation when accurately restoring the clean image from its haze-polluted counterpart. This paper proposes a novel Progressive Negative Enhancing (PNE) contrastive learning mechanism to fully exploit various types of negative information, thereby facilitating the traditional positive-oriented objective function for image dehazing. The proposed method can progressively update the negative samples during model training, to steadily squeeze the restored image towards its desired clean target from various directions. Furthermore, considering the image dehazing task as a many-to-one feature mapping problem, we also make an early effort to enhance the robustness of the dehazing model under variational haze …

IEEE Journal of Biomedical and Health Informatics

Magnetic resonance imaging (MRI)-based deep neural networks (DNN) have been widely developed to perform prostate cancer (PCa) classification. However, in real-world clinical situations, prostate MRIs can be easily impacted by rectal artifacts, which have been found to lead to incorrect PCa classification. Existing DNN-based methods typically do not consider the interference of rectal artifacts on PCa classification, and do not design specific strategy to address this problem. In this study, we proposed a novel Targeted adversarial training with Proprietary Adversarial Samples (TPAS) strategy to defend the PCa classification model against the influence of rectal artifacts. Specifically, based on clinical prior knowledge, we generated proprietary adversarial samples with rectal artifact-pattern adversarial noise, which can severely mislead PCa classification models optimized by the ordinary training strategy. We then …

Multimedia Tools and Applications

Automatic classification of pathological images is an important task in the thyroid carcinoma histopathological analysis. Currently, histological diagnosis has become a leading field in medical imaging computing, which can reduce the burden of pathologists and the misdiagnosis rate. At present, works on designing convocational neural networks (CNNs) for automatically classifying pathological images are increasing rapidly. However, classification of thyroid carcinoma pathological images remains challenging due to the small differences between benign and malignant observed from pathological images. The existing CNN methods cannot classify the pathological images well. Inspired by the diagnosis process observed by the pathologists and the reasoning ability of CapsNet, we propose a novel capsule network named PTC-CapsNet based on semantic features derived from multi-magnification pathological …

arXiv preprint arXiv:2401.04956

Eye movement (EM) is a new highly secure biometric behavioral modality that has received increasing attention in recent years. Although deep neural networks, such as convolutional neural network (CNN), have recently achieved promising performance, current solutions fail to capture local and global temporal dependencies within eye movement data. To overcome this problem, we propose in this paper a mixed transformer termed EmMixformer to extract time and frequency domain information for eye movement recognition. To this end, we propose a mixed block consisting of three modules, transformer, attention Long short-term memory (attention LSTM), and Fourier transformer. We are the first to attempt leveraging transformer to learn long temporal dependencies within eye movement. Second, we incorporate the attention mechanism into LSTM to propose attention LSTM with the aim to learn short temporal dependencies. Third, we perform self attention in the frequency domain to learn global features. As the three modules provide complementary feature representations in terms of local and global dependencies, the proposed EmMixformer is capable of improving recognition accuracy. The experimental results on our eye movement dataset and two public eye movement datasets show that the proposed EmMixformer outperforms the state of the art by achieving the lowest verification error.

Pattern Recognition

Image aesthetic assessment (IAA) aims to design algorithms that can make human-like aesthetic decisions. Due to its high subjectivity and complexity, visual information alone is limited to fully predict the aesthetic quality of an image. More and more researchers try to use complementary information from user comments. However, user comments are not always available due to various technical and practical reasons. Therefore, it is necessary to find a way to reconstruct the missing textual information for aesthetic prediction with visual information only. This paper solves this problem by proposing a Confidence-based Dynamic Cross-modal Memory Network (CDCM-Net). Specifically, the proposed CDCM-Net consists of two key components: Visual and Textual Memory (VTM) network and Confidence-based Dynamical Multi-modal Fusion module (CDMF). VTM is based on the key–value memory network. It consists of …

arXiv preprint arXiv:2401.14707

Deep neural networks are vulnerable to adversarial samples. Adversarial fine-tuning methods aim to enhance adversarial robustness through fine-tuning the naturally pre-trained model in an adversarial training manner. However, we identify that some latent features of adversarial samples are confused by adversarial perturbation and lead to an unexpectedly increasing gap between features in the last hidden layer of natural and adversarial samples. To address this issue, we propose a disentanglement-based approach to explicitly model and further remove the latent features that cause the feature gap. Specifically, we introduce a feature disentangler to separate out the latent features from the features of the adversarial samples, thereby boosting robustness by eliminating the latent features. Besides, we align features in the pre-trained model with features of adversarial samples in the fine-tuned model, to further benefit from the features from natural samples without confusion. Empirical evaluations on three benchmark datasets demonstrate that our approach surpasses existing adversarial fine-tuning methods and adversarial training baselines.

IEEE Transactions on Geoscience and Remote Sensing

Recently, remote sensing super-resolution (SR) tasks have been widely studied and achieved remarkable performance. However, due to the complex texture and serious image degeneration, the conventional methods (e.g. CNN-based, GAN-based) cannot reconstruct high-resolution (HR) remote sensing images with a large SR factor (≥ ×8). In this paper, we model the large-factor super-resolution (LFSR) task as a referenced diffusion process and explore how to embed pixel-wise constraint into the popular diffusion model. Following this motivation, we propose the first diffusion-based LFSR method named texture consistency diffusion model (TCDM) for remote sensing images. Specifically, we build a novel conditional truncated noise generator (CTNG) in TCDM to simultaneously generate the expectation of posterior probability p ( x t-1 | x t ) and the truncated noise image. With the predicted truncated noise image …

IEEE Transactions on Image Processing

The key to multi-object tracking is its stability and the retention of identity information. A common problem with most detection-based approaches is trusting and using all the detector outputs for the association. However, some settings of detectors can affect stable long-range tracking. Based on the principle of reducing the association noise in the detection processing step, we propose a new framework, the Box application Pattern Mining Tracker (BPMTrack), to address this issue. Specifically, we worked on three main aspects: output threshold, association strategy, and motion model. Due to the problem of inconsistency between classification scores and localization accuracy, we propose the Box Quality Estimation Network (BQENet) to predict the localization quality scores of all detections in the current frame, reserving high-quality boxes for the tracker. In addition, based on observations of intensive scenarios, we …

IEEE Transactions on Multimedia

The usual active learning is to sample unlabeled set by designing efficient sample information evaluation algorithms. However, information redundancy between candidate sets is often overlooked. This can cause similar data to be labeled repeatedly, producing ineffective gains for the model. In this paper, we proposed an Unsupervised Redundant Feature Elimination Active Learning module (URFEAL), which utilizes the information feature coincidence of the unlabeled set to eliminate information redundant data, thus guaranteeing the validity of each candidate data. URFEAL consists of feature clusterer and eliminator. The feature clusterer computes class boundaries based on feature densities to discretize each class of the candidate set, and the eliminator judges data similarity by overlapping degree to eliminate redundant data features. Furthermore, we propose an anti-noise sampling strategy Outlier Feature …

arXiv preprint arXiv:2403.02818

Current state-of-the-art (SOTA) 3D object detection methods often require a large amount of 3D bounding box annotations for training. However, collecting such large-scale densely-supervised datasets is notoriously costly. To reduce the cumbersome data annotation process, we propose a novel sparsely-annotated framework, in which we just annotate one 3D object per scene. Such a sparse annotation strategy could significantly reduce the heavy annotation burden, while inexact and incomplete sparse supervision may severely deteriorate the detection performance. To address this issue, we develop the SS3D++ method that alternatively improves 3D detector training and confident fully-annotated scene generation in a unified learning scheme. Using sparse annotations as seeds, we progressively generate confident fully-annotated scenes based on designing a missing-annotated instance mining module and reliable background mining module. Our proposed method produces competitive results when compared with SOTA weakly-supervised methods using the same or even more annotation costs. Besides, compared with SOTA fully-supervised methods, we achieve on-par or even better performance on the KITTI dataset with about 5x less annotation cost, and 90% of their performance on the Waymo dataset with about 15x less annotation cost. The additional unlabeled training scenes could further boost the performance. The code will be available at https://github.com/gaocq/SS3D2.

Proceedings of the AAAI Conference on Artificial Intelligence

Recently MLP-based methods have shown strong performance in point cloud analysis. Simple MLP architectures are able to learn geometric features in local point groups yet fail to model long-range dependencies directly. In this paper, we propose Point Deformable Network (PDNet), a concise MLP-based network that can capture long-range relations with strong representation ability. Specifically, we put forward Point Deformable Aggregation Module (PDAM) to improve representation capability in both long-range dependency and adaptive aggregation among points. For each query point, PDAM aggregates information from deformable reference points rather than points in limited local areas. The deformable reference points are generated data-dependent, and we initialize them according to the input point positions. Additional offsets and modulation scalars are learned on the whole point features, which shift the deformable reference points to the regions of interest. We also suggest estimating the normal vector for point clouds and applying Enhanced Normal Embedding (ENE) to the geometric extractors to improve the representation ability of single-point. Extensive experiments and ablation studies on various benchmarks demonstrate the effectiveness and superiority of our PDNet.

arXiv preprint arXiv:2403.18660

In recent years, instruction-based image editing methods have garnered significant attention in image editing. However, despite encompassing a wide range of editing priors, these methods are helpless when handling editing tasks that are challenging to accurately describe through language. We propose InstructBrush, an inversion method for instruction-based image editing methods to bridge this gap. It extracts editing effects from exemplar image pairs as editing instructions, which are further applied for image editing. Two key techniques are introduced into InstructBrush, Attention-based Instruction Optimization and Transformation-oriented Instruction Initialization, to address the limitations of the previous method in terms of inversion effects and instruction generalization. To explore the ability of instruction inversion methods to guide image editing in open scenarios, we establish a TransformationOriented Paired Benchmark (TOP-Bench), which contains a rich set of scenes and editing types. The creation of this benchmark paves the way for further exploration of instruction inversion. Quantitatively and qualitatively, our approach achieves superior performance in editing and is more semantically consistent with the target editing effects.

Neurocomputing

Image quality assessment (IQA) aims to build a quality prediction model to assess image quality automatically rather than artificially. Due to a lack of reference images, blind image quality assessment (BIQA) has become an attractive yet challenging research topic. Inspired by the hierarchical perception mechanism in the human visual system, some existing BIQA methods aggregate multi-stage features of a convolutional neural network (CNN). However, they are regardless of the latent dependencies. To solve this problem, we propose a novel BIQA method based on hierarchical dependency learning and quality aggregation (HDLaQA). The proposed method includes multi-stage feature extraction, hierarchical dependency learning, and quality aggregation. In multi-stage feature extraction, a CNN is used as the feature extractor and multi-stage features are output for further learning. In hierarchical dependency …

IEEE Transactions on Information Forensics and Security

The advancement of face recognition technology has delivered substantial societal advantages. However, it has also raised global privacy concerns due to the ubiquitous collection and potential misuse of individuals’ facial data. This presents a notable paradox: while there is a societal demand for a robust face recognition ecosystem to ensure public security and convenience, an increasing number of individuals are hesitant to release their facial data. Numerous studies have endeavored to find such a utility-privacy trade-off, yet many struggle with the dilemma of prioritizing one at the expense of the other. In response to this challenge, this paper proposes PRO-Face C, a novel paradigm for privacy-preserving recognition of obfuscated faces via a dedicated feature compensation mechanism, aimed at optimizing the equilibrium between privacy preservation and utility maximization. The proposed approach is …

Engineering Applications of Artificial Intelligence

Automated image enhancement algorithms have a profound impact on human life today. To solve the problems of luminance, lack of detail information, and overall color tone bias of images taken by mobile devices, a novel framework of core-attributes enhanced generative adversarial network (CAE-GAN) is designed to improve these core attributes of enhanced images. The generator in CAE-GAN mainly consists of a luminance correction encoder (LCE) and a high-frequency supplementary decoder (HFSD). To target the adaptive luminance improvement for each location, the encoder based on LCE is designed by combining the extracted prior knowledge of luminance. Meanwhile, a decoder based on HFSD is proposed to fill in missing edge details during the image reconstruction process. In addition, a multi-scale statistical characteristics distinction branch (MSCDB) is proposed to correct the overall tone …

IEEE Transactions on Image Processing

Due to many unmarked data, there has been tremendous interest in developing unsupervised feature selection methods, among which graph-guided feature selection is one of the most representative techniques. However, the existing feature selection methods have the following limitations: (1) All of them only remove redundant features shared by all classes and neglect the class-specific properties; thus, the selected features cannot well characterize the discriminative structure of the data. (2) The existing methods only consider the relationship between the data and the corresponding neighbor points by Euclidean distance while neglecting the differences with other samples. Thus, existing methods cannot encode discriminative information well. (3) They adaptively learn the graph in the original or embedding space. Thus, the learned graph cannot characterize the data’s cluster structure. To solve these limitations …

arXiv preprint arXiv:2402.00672

Unsupervised visible-infrared person re-identification (USL-VI-ReID) aims to retrieve pedestrian images of the same identity from different modalities without annotations. While prior work focuses on establishing cross-modality pseudo-label associations to bridge the modality-gap, they ignore maintaining the instance-level homogeneous and heterogeneous consistency in pseudo-label space, resulting in coarse associations. In response, we introduce a Modality-Unified Label Transfer (MULT) module that simultaneously accounts for both homogeneous and heterogeneous fine-grained instance-level structures, yielding high-quality cross-modality label associations. It models both homogeneous and heterogeneous affinities, leveraging them to define the inconsistency for the pseudo-labels and then minimize it, leading to pseudo-labels that maintain alignment across modalities and consistency within intra-modality structures. Additionally, a straightforward plug-and-play Online Cross-memory Label Refinement (OCLR) module is proposed to further mitigate the impact of noisy pseudo-labels while simultaneously aligning different modalities, coupled with a Modality-Invariant Representation Learning (MIRL) framework. Experiments demonstrate that our proposed method outperforms existing USL-VI-ReID methods, highlighting the superiority of our MULT in comparison to other cross-modality association methods. The code will be available.

Psychological Medicine

Background Preterm birth is a global health problem and associated with increased risk of long-term developmental impairments, but findings on the adverse outcomes of prematurity have been inconsistent. Methods Data were obtained from the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development (ABCD) Study. We identified 1706 preterm children and 1865 matched individuals as Control group and compared brain structure (MRI data), cognitive function and mental health symptoms. Results Results showed that preterm children had higher psychopathological risk and lower cognitive function scores compared to controls. Structural MRI analysis indicated that preterm children had higher cortical thickness in the medial orbitofrontal cortex, parahippocampal gyrus, temporal and occipital gyrus; smaller volumes in the temporal and parietal gyrus, cerebellum, insula and …

Psychological Medicine

BackgroundCardiovascular disease (CVD) is excessively prevalent and premature in bipolar disorder (BD), even after controlling for traditional cardiovascular risk factors. The increased risk of CVD in BD may be subserved by microvascular dysfunction. We examined coronary microvascular function in relation to youth BD.MethodsParticipants were 86 youth, ages 13–20 years (n = 39 BD, n = 47 controls). Coronary microvascular reactivity (CMVR) was assessed using quantitative T2 magnetic resonance imaging during a validated breathing-paradigm. Quantitative T2 maps were acquired at baseline, following 60-s of hyperventilation, and every 10-s thereafter during a 40-s breath-hold. Left ventricular structure and function were evaluated based on 12–15 short- and long-axis cardiac-gated cine images. A linear mixed-effects model that controlled for age, sex, and body mass index assessed for between-group …

Psychological medicine

BackgroundSuicidal behaviors are prevalent among college students; however, students remain reluctant to seek support. We developed a predictive algorithm to identify students at risk of suicidal behavior and used telehealth to reduce subsequent risk.MethodsData come from several waves of a prospective cohort study (2016–2022) of college students (n = 5454). All first-year students were invited to participate as volunteers. (Response rates range: 16.00–19.93%). A stepped-care approach was implemented: (i) all students received a comprehensive list of services; (ii) those reporting past 12-month suicidal ideation were directed to a safety planning application; (iii) those identified as high risk of suicidal behavior by the algorithm or reporting 12-month suicide attempt were contacted via telephone within 24-h of survey completion. Intervention focused on support/safety-planning, and referral to services for this …

Psychological Medicine

BackgroundMild traumatic brain injury (mTBI) is common in children. Long-term cognitive and behavioral outcomes as well as underlying structural brain alterations following pediatric mTBI have yet to be determined. In addition, the effect of age-at-injury on long-term outcomes is largely unknown.MethodsChildren with a history of mTBI (n = 406; Mage = 10 years, SDage = 0.63 years) who participated in the Adolescent Brain Cognitive Development (ABCD) study were matched (1:2 ratio) with typically developing children (TDC; n = 812) and orthopedic injury (OI) controls (n = 812). Task-based executive functioning, parent-rated executive functioning and emotion-regulation, and self-reported impulsivity were assessed cross-sectionally. Regression models were used to examine the effect of mTBI on these domains. The effect of age-at-injury was assessed by comparing children with their first mTBI at either 0-3, 4-7, or …

Psychological Medicine

When this article was published in Psychological Medicine, it omitted to capitalise ‘Mini International Neuropsychiatric Interview’in its title. This has now been updated online. The author apologises for this error.

Psychological Medicine

BackgroundIncidence of first-episode psychosis (FEP) varies substantially across geographic regions. Phenotypes of subclinical psychosis (SP), such as psychotic-like experiences (PLEs) and schizotypy, present several similarities with psychosis. We aimed to examine whether SP measures varied across different sites and whether this variation was comparable with FEP incidence within the same areas. We further examined contribution of environmental and genetic factors to SP.MethodsWe used data from 1497 controls recruited in 16 different sites across 6 countries. Factor scores for several psychopathological dimensions of schizotypy and PLEs were obtained using multidimensional item response theory models. Variation of these scores was assessed using multi-level regression analysis to estimate individual and between-sites variance adjusting for age, sex, education, migrant, employment and relational …

Psychological Medicine

BackgroundThe relationship between childhood trauma (CT) and psychotic symptoms in patients with schizophrenia (SCZ), and subthreshold psychotic experiences in non-clinical populations is well-established. However, little is known about the relationship between subtypes of trauma and specific symptoms in patients, their siblings, and controls. It is also not clear which variables mediate the relationship between trauma and psychotic symptoms.MethodsSeven hundred and forty-two patients with SCZ, 718 of their unaffected siblings and 1039 controls from three EU-GEI sites were assessed for CT, symptom severity, and cognitive schemas about self/others. CT was assessed with the Childhood Trauma Questionnaire, and cognitive schemas were assessed by The Brief Core Schema Scale.ResultsPatients with psychosis were affected by CT more than their siblings and controls in all domains. Childhood …

Psychological Medicine

BackgroundCerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. We investigated the association of retinal microvascular function, a proxy for microvascular function in the brain, with incidence and trajectories of clinically relevant depressive symptoms.MethodsLongitudinal data are from The Maastricht Study of 5952 participants (59.9 ± 8.5 years/49.7% women) without clinically relevant depressive symptoms at baseline (2010–2017). Central retinal arteriolar equivalent and central retinal venular equivalent (CRAE and CRVE) and a composite score of flicker light-induced retinal arteriolar and venular dilation were assessed at baseline. We assessed incidence and trajectories of clinically relevant depressive symptoms (9-item Patient Health Questionnaire score ⩾10). Trajectories included continuously low prevalence …

Psychological medicine

BackgroundYouth adversity is associated with persistence of depression and anxiety symptoms. This association may be greater for disadvantaged societal groups (such as females) compared with advantaged groups (e.g. males). Given that persistent symptoms are observed across a range of disadvantaged, minoritized, and neurodivergent groups (e.g. low compared with high socio-economic status [SES]), the intersection of individual characteristics may be an important moderator of inequality.MethodsData from HeadStart Cornwall (N = 4441) was used to assess the effect of youth adversity on combined symptoms of depression and anxiety (Strengths and Difficulties Questionnaire emotional problems subscale) measured at three time-points in 11–14-year-olds. Latent trajectories and regressions were estimated for eight intersectionality profiles (based on gender, SES, and hyperactivity/inattention), and …

Psychological medicine

BackgroundSchizophrenia is associated with hypoactivation of reward sensitive brain areas during reward anticipation. However, it is unclear whether these neural functions are similarly impaired in other disorders with psychotic symptomatology or individuals with genetic liability for psychosis. If abnormalities in reward sensitive brain areas are shared across individuals with psychotic psychopathology and people with heightened genetic liability for psychosis, there may be a common neural basis for symptoms of diminished pleasure and motivation.MethodsWe compared performance and neural activity in 123 people with a history of psychosis (PwP), 81 of their first-degree biological relatives, and 49 controls during a modified Monetary Incentive Delay task during fMRI.ResultsPwP exhibited hypoactivation of the striatum and anterior insula (AI) during cueing of potential future rewards with each diagnostic group …

Psychological Medicine

BackgroundAccumulating data show that probiotics may be beneficial for reducing depressive, anxiety, and stress symptoms. However, the best combinations and species of probiotics have not been identified. The objective of our study was to assess the most effective combinations and components of different probiotics through network meta-analysis.MethodA systematic search of four databases, PubMed, Web of Science, Cochrane, and Embase, was conducted from inception to 11 January 2024. The GRADE framework was used to assess the quality of evidence contributing to each network estimate.ResultsWe deemed 45 trials eligible, these included 4053 participants and 10 types of interventions. The quality of evidence was rated as high or moderate. The NMA revealed that Bifidobacterium exhibited a greater probability of being the optimal probiotic species for improving anxiety symptoms (SMD = −0.80; 95 …

Psychological Medicine

BackgroundThe age-related heterogeneity in major depressive disorder (MDD) has received significant attention. However, the neural mechanisms underlying such heterogeneity still need further investigation. This study aimed to explore the common and distinct functional brain abnormalities across different age groups of MDD patients from a large-sample, multicenter analysis.MethodsThe analyzed sample consisted of a total of 1238 individuals including 617 MDD patients (108 adolescents, 12–17 years old; 411 early-middle adults, 18–54 years old; and 98 late adults, > = 55 years old) and 621 demographically matched healthy controls (60 adolescents, 449 early-middle adults, and 112 late adults). MDD-related abnormalities in brain functional connectivity (FC) patterns were investigated in each age group separately and using the whole pooled sample, respectively.ResultsWe found shared FC reductions …

Psychological Medicine

BackgroundScreen time in infancy is linked to changes in social-emotional development but the pathway underlying this association remains unknown. We aim to provide mechanistic insights into this association using brain network topology and to examine the potential role of parent–child reading in mitigating the effects of screen time.MethodsWe examined the association of screen time on brain network topology using linear regression analysis and tested if the network topology mediated the association between screen time and later socio-emotional competence. Lastly, we tested if parent–child reading time was a moderator of the link between screen time and brain network topology.ResultsInfant screen time was significantly associated with the emotion processing-cognitive control network integration (p = 0.005). This network integration also significantly mediated the association between screen time and …

Psychological Medicine

BackgroundTo address if the long-standing association between maternal infection, depression/anxiety in pregnancy, and offspring neurodevelopmental disorder (NDD) is causal, we conducted two negative-control studies.MethodsFour primary care cohorts of UK children (pregnancy, 1 and 2 years prior to pregnancy, and siblings) born between 1 January 1990 and 31 December 2017 were constructed. NDD included autism/autism spectrum disorder, attention-deficit/hyperactivity disorder, intellectual disability, cerebral palsy, and epilepsy. Maternal exposures included depression/anxiety and/or infection. Maternal (age, smoking status, comorbidities, body mass index, NDD); child (gender, ethnicity, birth year); and area-level (region and level of deprivation) confounders were captured. The NDD incidence rate among (1) children exposed during or outside of pregnancy and (2) siblings discordant for exposure in …

Psychological Medicine

BackgroundChildbirth may be a traumatic experience and vulnerability to posttraumatic stress disorder (PTSD) may increase the risk of postpartum depression (PPD). We investigated whether genetic vulnerability to PTSD as measured by polygenic score (PGS) increases the risk of PPD and whether a predisposition to PTSD in PPD cases exceeds that of major depressive disorder (MDD) outside the postpartum period.MethodsThis case-control study included participants from the iPSYCH2015, a case-cohort of all singletons born in Denmark between 1981 and 2008. Restricting to women born between 1981 and 1997 and excluding women with a first diagnosis other than depression (N = 22 613), 333 were identified with PPD. For each PPD case, 999 representing the background population and 993 with MDD outside the postpartum were matched by calendar year at birth, cohort selection, and age. PTSD PGS …

Psychological Medicine

BackgroundPost-traumatic stress disorder (PTSD) is associated with cognitive impairments. It is unclear whether problems persist after PTSD symptoms remit.MethodsData came from 12 270 trauma-exposed women in the Nurses' Health Study II. Trauma and PTSD symptoms were assessed using validated scales to determine PTSD status as of 2008 (trauma/no PTSD, remitted PTSD, unresolved PTSD) and symptom severity (lifetime and past-month). Starting in 2014, cognitive function was assessed using the Cogstate Brief Battery every 6 or 12 months for up to 24 months. PTSD associations with baseline cognition and longitudinal cognitive changes were estimated by covariate-adjusted linear regression and linear mixed-effects models, respectively.ResultsCompared to women with trauma/no PTSD, women with remitted PTSD symptoms had a similar cognitive function at baseline, while women with unresolved …

Psychological Medicine

BackgroundVery-late-onset schizophrenia-like psychosis (VLOSLP) is associated with significant burden. Its clinical importance is increasing as the global population of older adults rises, yet owing to limited research in this population, the neurobiological underpinnings of VLOSP remain insufficiently clarified. Here we address this knowledge gap using novel morphometry techniques to investigate grey matter volume (GMV) differences between VLOSLP and healthy older adults, and their correlations with neuropsychological scores.MethodsIn this cross-sectional study, we investigated whole-brain GMV differences between 35 individuals with VLOSLP (mean age 76.7, 26 female) and 36 healthy controls (mean age 75.7, 27 female) using whole-brain voxel-based morphometry (VBM) and supplementary source-based morphometry (SBM) on high resolution 3D T1-weighted MRI images. Additionally, we investigated …

Psychological Medicine

BackgroundFatigue is a central feature of myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), but many ME/CFS patients also report comorbid pain symptoms. It remains unclear whether these symptoms are related to similar or dissociable brain networks. This study used resting-state fMRI to disentangle networks associated with fatigue and pain symptoms in ME/CFS patients, and to link changes in those networks to clinical improvements following cognitive behavioral therapy (CBT).MethodsRelationships between pain and fatigue symptoms and cortico-cortical connectivity were assessed within ME/CFS patients at baseline (N = 72) and after CBT (N = 33) and waiting list (WL, N = 18) and compared to healthy controls (HC, N = 29). The analyses focused on four networks previously associated with pain and/or fatigue, i.e. the fronto-parietal network (FPN), premotor network (PMN), somatomotor …

Psychological Medicine

BackgroundThere is growing evidence for the use of acceptance-commitment therapy (ACT) for the treatment of obsessive-compulsive disorder (OCD). However, few fully implemented ACT have been conducted on the neural mechanisms underlying its effect on OCD. Thus, this study aimed to elucidate the neural correlates of ACT in patients with OCD using task-based and resting-state functional magnetic resonance imaging (fMRI).MethodsPatients with OCD were randomly assigned to the ACT (n = 21) or the wait-list control group (n = 21). An 8-week group-format ACT program was provided to the ACT group. All participants underwent an fMRI scan and psychological measurements before and after 8 weeks.ResultsPatients with OCD showed significantly increased activation in the bilateral insula and superior temporal gyri (STG), induced by the thought-action fusion task after ACT intervention. Further psycho …

Psychological medicine

BackgroundSchizotypy represents an index of psychosis-proneness in the general population, often associated with childhood trauma exposure. Both schizotypy and childhood trauma are linked to structural brain alterations, and it is possible that trauma exposure moderates the extent of brain morphological differences associated with schizotypy.MethodsWe addressed this question using data from a total of 1182 healthy adults (age range: 18–65 years old, 647 females/535 males), pooled from nine sites worldwide, contributing to the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Schizotypy working group. All participants completed both the Schizotypal Personality Questionnaire Brief version (SPQ-B), and the Childhood Trauma Questionnaire (CTQ), and underwent a 3D T1-weighted brain MRI scan from which regional indices of subcortical gray matter volume and cortical thickness were …