Bioplastics for a circular economy

Advanced Healthcare Materials

Percutaneous cryoablation is a common clinical therapy for metastatic and primary cancer. There are rare clinical reports of cryoablation inducing regression of distant metastases, known as the “abscopal” effect. Intratumoral immunoadjuvants may be able to augment the abscopal rate of cryoablation, but existing intratumoral therapies suffer from the need for frequent injections and inability to confirm target delivery, leading to poor clinical trial outcomes. To address these shortcomings, an injectable thermoresponsive gel‐based controlled release formulation is developed for the FDA‐approved Toll‐like‐receptor 7 (TLR7) agonist imiquimod (“Imigel”) that forms a tumor‐resident depot upon injection and contains a contrast agent for visualization under computed tomography (CT). The poly‐lactic‐co‐glycolic acid‐polyethylene glycol‐poly‐lactic‐co‐glycolic acid (PLGA‐PEG‐PLGA)‐based amphiphilic copolymer gel …

Angewandte Chemie

Phosphor‐zentrierte Disbiradikale, in denen die Radikalzentren als einzelne Spin‐Dubletts mit schwacher Spin‐Spin‐Wechselwirkung vorliegen, waren bisher nicht bekannt. Ausgehend von Monoradikalen des Typs [⋅P(μ‐NTer)2P−R] ist es uns nun gelungen, zwei monoradikalische Phosphorzentren durch geeignete Wahl eines Linkers zu verknüpfen. Zu diesem Zweck wurde das Biradikal [⋅P(μ‐NTer)2P⋅] (1) mit 1,6‐Dibromhexan umgesetzt, wodurch die bromierte Spezies {Br[P(μ‐NTer)]2}2C6H12 (3) entstand. Die anschließende Reduktion mit KC8 führte zur Bildung des Disbiradikals {⋅[P(μ‐NTer)]2}2C6H12 (4), das sich durch einen großen Abstand zwischen den radikalischen Phosphorzentren im Festkörper auszeichnet und mit annähernd 100 % den bisher höchsten Biradikalcharakter in einem P‐zentrierten Biradikal aufweist. Die EPR‐spektroskopische Untersuchung ergab ein Drei‐Linien‐Signal in …

Angewandte Chemie International Edition

Phosphorus‐centered disbiradicals, in which the radical sites exist as individual spin doublets with weak spin‐spin interaction have not been known so far. Starting from monoradicals of the type [⋅P(μ‐NTer)2P−R], we have now succeeded in linking two such monoradical phosphorus centers by appropriate choice of a linker. To this end, biradical [⋅P(μ‐NTer)2P⋅] (1) was treated with 1,6‐dibromohexane, affording the brominated species {Br[P(μ‐NTer)]2}2C6H12 (3). Subsequent reduction with KC8 led to the formation of the disbiradical {⋅[P(μ‐NTer)]2}2C6H12 (4) featuring a large distance between the radical phosphorus sites in the solid state and formally the highest biradical character observed in a P‐centered biradical so far, approaching 100 %. EPR spectroscopy revealed a three‐line signal in solution with a considerably larger exchange interaction than would be expected from the molecular structure of …

Angewandte Chemie International Edition

The ancient art of arranging diatoms (very small algae) under the microscope with a single hair is connected on the Cover picture with the research reported in this Communication (e202318210). The diatoms make up the formula of the disbiradical reported in the study and its characteristic three-line EPR signal. The milky way in the background represents the through-space interaction delivering the explanation for the peculiar EPR signal pattern.(Design and idea: Jan Rosenboom).

Angewandte Chemie

Titelbild: Design eines Phosphor‑zentrierten Disbiradikals (Angew. Chem. 10/2024) - NASA/ADS Now on home page ads icon ads Enable full ADS view NASA/ADS Titelbild: Design eines Phosphor‑zentrierten Disbiradikals (Angew. Chem. 10/2024) Rosenboom, Jan ; Taube, Florian ; Teichmeier, Leon ; Villinger, Alexander ; Reinhard, Maik ; Demeshko, Serhiy ; Bennati, Marina ; Bresien, Jonas ; Corzilius, Björn ; Schulz, Axel Abstract Publication: Angewandte Chemie Pub Date: March 2024 DOI: 10.1002/ange.202401336 Bibcode: 2024AngCh.136E1336R full text sources Publisher | © The SAO/NASA Astrophysics Data System adshelp[at]cfa.harvard.edu The ADS is operated by the Smithsonian Astrophysical Observatory under NASA Cooperative Agreement NNX16AC86A NASA logo Smithsonian logo Resources About ADS ADS Help What's New Careers@ADS Social @adsabs ADS Blog Project Switch to full ADS …

2020-10-27 Assigned to THE BRIGHAM AND WOMEN'S HOSPITAL, INC. reassignment THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ALEXIS, FRANK, FAROKHZAD, OMID C.

Nature biomedical engineering

Improvements in ingestible electronics with the capacity to sense physiological and pathophysiological states have transformed the standard of care for patients. Yet, despite advances in device development, significant risks associated with solid, non-flexible gastrointestinal transiting systems remain. Here, we report the design and use of an ingestible, flexible piezoelectric device that senses mechanical deformation within the gastric cavity. We demonstrate the capabilities of the sensor in both in vitro and ex vivo simulated gastric models, quantify its key behaviours in the gastrointestinal tract using computational modelling and validate its functionality in awake and ambulating swine. Our proof-of-concept device may lead to the development of ingestible piezoelectric devices that might safely sense mechanical variations and harvest mechanical energy inside the gastrointestinal tract for the diagnosis and treatment …

A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.

(63) Continuation of application No. 15/484,892, filed on A23L 33/10 (201608); 461 K 31/593 Apr. 11, 2017, now Pat. No. 11,541,017, which is a (2013 01); 461 K 31/23 (201301); 461 K continuation of application No. 14/572,346, filed on 31/875 (2013 01); 461 K 33/18 (201301); Dec. 16, 2014, now Pat. No. 9,649.279. A6IK 33/26 (201301); 461 K 45/06 (201301);

Journal of Vascular and Interventional Radiology

Abstract No. 4▪ FEATURED ABSTRACT Image-Guided Intratumoral Cancer Vaccine to Treat Metastatic Immunotherapy Resistant Cancer with and without CryoablationAuthor links open overlay panel A. Som 1, E. Wehrenberg-Klee 1, J. Rosenboom 2, A. Chandler 2, G. Ndakwah 2, J. Kim 1, V. Feig 3, A. Marcos-Vidal 1, F. Fintelmann 1, A. Basu 2, R. Langer 2, G. Traverso 3, U. Mahmood 1

Residence devices for long term delivery of therapeutic compounds and/or for sensing one or more relevant parameters in vivo are disclosed. In one embodiment, a residence device may include a plurality of links interconnected by a corresponding plurality of flexible hinges to permit the residence device to be deformed into a contracted configuration and subsequently permitted to return to an expanded configuration once positioned in a desired location, such as the stomach, of a subject. In some instances, at least a portion of the interconnected links may include a first link segment, a second link segment, and a coupling that selectively connects the first link segment to the second link segment. The coupling may be configured to weaken or decouple a connection between the first link segment and the second link segment when exposed to a temperature greater than a threshold temperature to selectively weaken …

Journal of Vascular and Interventional Radiology

Abstract No. 57 Local Biliary Injection of Cisplatin for Chemotherapy Delivery in Patients with Cholangiocarcinoma

Drug delivery articles, resident articles, and retrieval systems eg, for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release eg, with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (eg, greater than or equal to 1 gram).

Advanced Materials

Actively triggerable materials, which break down upon introduction of an exogenous stimulus, enable precise control over the lifetime of biomedical technologies, as well as adaptation to unforeseen circumstances, such as changes to an established treatment plan. Yet, most actively triggerable materials are low‐strength polymers and hydrogels with limited long‐term durability. By contrast, metals possess advantageous functional properties, including high mechanical strength and conductivity, that are desirable across several applications within biomedicine. To realize actively triggerable metals, a mechanism called liquid metal embrittlement is leveraged, in which certain liquid metals penetrate the grain boundaries of certain solid metals and cause them to dramatically weaken or disintegrate. In this work, it is demonstrated that eutectic gallium indium (EGaIn), a biocompatible alloy of gallium, can be formulated to …

2018-01-30 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), US GOVERNMENT CONFIRMATORY LICENSE (SEE DOCUMENT FOR DETAILS). Assignors: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Dalton Transactions

The reaction of the singlet biradical [P(μ-NTer)]2 with various aldehydes selectively yielded the corresponding [2.1.1]-bicyclic addition products in a very fast reaction. All products were fully characterized, including by NMR and vibrational spectroscopy as well as single-crystal X-ray diffraction. The mechanism of the addition was investigated theoretically using high-level ab initio methods (CCSD(T) with triple- and quadruple-zeta basis sets) and corresponds to a concerted cycloaddition reaction with a very low activation barrier. For comparison, the mechanisms of the literature-known cycloadditions of H2, alkenes, and alkynes were also studied, indicating a similar reaction profile for all unsaturated reactants.

Immunotherapy has revolutionized the contemporary oncology landscape, with durable responses possible across a range of cancer types. However, the majority of cancer patients do not respond to immunotherapy due to numerous immunosuppressive barriers. Efforts to overcome these barriers and increase systemic immunotherapy efficacy have sparked interest in the local intratumoral delivery of immune stimulants to activate the local immune response and subsequently drive systemic tumor immunity. While clinical evaluation of many therapeutic candidates is ongoing, development is hindered by a lack of imaging confirmation of local delivery, insufficient intratumoral drug distribution, and a need for repeated injections. The use of polymeric drug delivery systems, which have been widely used as platforms for both image guidance and controlled drug release, holds promise for delivery of intratumoral …

Chemistry–A European Journal

The activation of C−Br bonds in various bromoalkanes by the biradical [⋅P(μ‐NTer)2P⋅] (1) (Ter=2,6‐bis‐(2,4,6‐trimethylphenyl)‐phenyl) is reported, yielding trans‐addition products of the type [Br−P(μ‐NTer)2P−R] (2), so‐called 1,3‐substituted cyclo‐1,3‐diphospha‐2,4‐diazanes. This addition reaction, which represents a new easy approach to asymmetrically substituted cyclo‐1,3‐diphospha‐2,4‐diazanes, was investigated mechanistically by different spectroscopic methods (NMR, EPR, IR, Raman); the results suggested a stepwise radical reaction mechanism, as evidenced by the in‐situ detection of the phosphorus‐centered monoradical [⋅P(μ‐NTer)2P‐R].< To provide further evidence for the radical mechanism, [⋅P(μ‐NTer)2P‐Et] (3Et⋅) was synthesized directly by reduction of the bromoethane addition product [Br‐P(μ‐NTer)2P‐Et] (2 a) with magnesium, resulting in the formation of the persistent …

CHEMISTRY-A EUROPEAN JOURNAL

The activation of C-Br bonds in various bromoalkanes by the biradical [center dot P(mu-NTer)(2)P center dot] (1) (Ter=2,6-bis-(2,4,6-trimethylphenyl)-phenyl) is reported, yielding trans-addition products of the type [Br-P(mu-NTer)(2)P-R] (2), so-called 1,3-substituted cyclo-1,3-diphospha-2,4-diazanes. This addition reaction, which represents a new easy approach to asymmetrically substituted cyclo-1,3-diphospha-2,4-diazanes, was investigated mechanistically by different spectroscopic methods (NMR, EPR, IR, Raman); the results suggested a stepwise radical reaction mechanism, as evidenced by the in-situ detection of the phosphorus-centered monoradical [center dot P(mu-NTer)(2)P-R].< To provide further evidence for the radical mechanism, [center dot P(mu-NTer)(2)P-Et] (3Et center dot) was synthesized directly by reduction of the bromoethane addition product [Br-P(mu-NTer)(2)P-Et] (2 a) with magnesium …