Author Correction: A portrait of the Higgs boson by the CMS experiment ten years after the discovery

Nature

In the version of this article initially published, CMS Collaboration author names, affiliations and acknowledgements were omitted and have now been included in the HTML and PDF versions of the article.

European Physical Journal C

In Fig. 3, the y axis titles were mistakenly written showing a single-differential cross section in either dimuon pT or rapidity, when in fact the cross section is normalized by both the pT and rapidity ranges used for a given measurement point. The corrected version is shown in the new Fig. 3 provided below.

Nature physics

Protons consist of three valence quarks, two up-quarks and one down-quark, held together by gluons and a sea of quark-antiquark pairs. Collectively, quarks and gluons are referred to as partons. In a proton-proton collision, typically only one parton of each proton undergoes a hard scattering – referred to as single-parton scattering – leaving the remainder of each proton only slightly disturbed. Here, we report the study of double- and triple-parton scatterings through the simultaneous production of three J/ψ mesons, which consist of a charm quark-antiquark pair, in proton-proton collisions recorded with the CMS experiment at the Large Hadron Collider. We observed this process – reconstructed through the decays of J/ψ mesons into pairs of oppositely charged muons – with a statistical significance above five standard deviations. We measured the inclusive fiducial cross-section to be , and …

Journal of High Energy Physics

A search for supersymmetry is presented in events with a single charged lepton, electron or muon, and multiple hadronic jets. The data correspond to an integrated luminosity of 138 fb− 1 of proton-proton collisions at a center-of-mass energy of 13 TeV, recorded by the CMS experiment at the CERN LHC. The search targets gluino pair production, where the gluinos decay into final states with the lightest supersymmetric particle (LSP) and either a top quark-antiquark () pair, or a light-flavor quark-antiquark () pair and a virtual or on-shell W boson. The main backgrounds, pair and W+ jets production, are suppressed by requirements on the azimuthal angle between the momenta of the lepton and of its reconstructed parent W boson candidate, and by top quark and W boson identification based on a machine-learning technique. The number of observed events is consistent with the expectations from standard model …

The second-order () and third-order () Fourier coefficients describing the azimuthal anisotropy of prompt and nonprompt (from b-hadron decays) J/, as well as prompt (2S) mesons are measured in lead-lead collisions at a center-of-mass energy per nucleon pair of = 5.02 TeV. The analysis uses a data set corresponding to an integrated luminosity of 1.61 nb recorded with the CMS detector. The J/ and (2S) mesons are reconstructed using their dimuon decay channel. The and coefficients are extracted using the scalar product method and studied as functions of meson transverse momentum and collision centrality. The measured values for prompt J/ mesons are found to be larger than those for nonprompt J/ mesons. The prompt J/ values at high are found to be underpredicted by a model incorporating only parton energy loss effects in a quark-gluon plasma medium. Prompt and nonprompt J/ meson and prompt (2S) and values are also reported for the first time, providing new information about heavy quark interactions in the hot and dense medium created in heavy ion collisions.

The European Physical Journal C

Measurements of Higgs boson production, where the Higgs boson decays into a pair of τ leptons, are presented, using a sample of proton-proton collisions collected with the CMS experiment at a center-of-mass energy of, corresponding to an integrated luminosity of 138 fb-1. Three analyses are presented. Two are targeting Higgs boson production via gluon fusion and vector boson fusion: a neural network based analysis and an analysis based on an event categorization optimized on the ratio of signal over background events. These are complemented by an analysis targeting vector boson associated Higgs boson production. Results are presented in the form of signal strengths relative to the standard model predictions and products of cross sections and branching fraction to τ leptons, in up to 16 different kinematic regions. For the simultaneous measurements of the neural network based analysis and the …

Symmetry

The class of two-interacting-qubit spin–boson models with vanishing transverse fields on the spin-pair is studied. The model can be mapped exactly into two independent standard single-impurity spin–boson models where the role of the tunneling parameter is played by the spin–spin coupling. The dynamics of the magnetization are analyzed for different levels of (an)isotropy. The existence of a decoherence-free subspace, as well as of different classical regimes separated by a critical temperature, and symptoms of quantum (first-order and Kosterlitz–Thouless type) phase transitions in the Ohmic regime are brought to light.

IPPOG Annual Report 2021 with two parts. The first part corresponds to an introduction of the collaboration along with a description of the main activities in 2021. The second part provides a summary of main activities of the IPPOG members in 2021.

The European Physical Journal C

A search is presented for slepton pairs produced in proton–proton collisions at a center-of-mass energy of 13. The search is carried out in events containing two leptons in the final state, on the assumption that each slepton decays primarily to a lepton and a neutralino. Events are considered in which each lepton decays to one or more hadrons and a neutrino, or in which one of the leptons decays instead to an electron or a muon and two neutrinos. The data, collected with the CMS detector in 2016 and 2017, correspond to an integrated luminosity of 77.2. The observed data are consistent with the standard model background expectation. The results are used to set 95% confidence level upper limits on the cross section for slepton pair production in various models for slepton masses between 90 and 200 and neutralino masses of 1, 10, and 20. In the case of purely left-handed slepton production and …

The azimuthal anisotropy of Υ (1S) mesons in high-multiplicity proton-lead collisions is studied using data collected by the CMS experiment at a nucleon-nucleon centerof-mass energy of 8.16 TeV. The Υ (1S) mesons are reconstructed using their dimuon decay channel. The anisotropy is characterized by the second Fourier harmonic coefficients, found using a two-particle correlation technique, in which the Υ (1S) mesons are correlated with charged hadrons. A large pseudorapidity gap is used to suppress short-range correlations. Nonflow contamination from the dijet background is removed using a low-multiplicity subtraction method, and the results are presented as a function of Υ (1S) transverse momentum. The azimuthal anisotropies are smaller than those found for charmonia in proton-lead collisions at the same collision energy, but are consistent with values found for Υ (1S) mesons in lead-lead interactions at a nucleon-nucleon center-of-mass energy of 5.02 TeV.

Abstract The ATLAS and CMS Collaborations both use POWHEG+ PYTHIA8 for their nominal Monte-Carlo simulations. Presented here is a second iteration of agreed-upon common settings for such a setup, in order to ease comparison and combination of ATLAS and CMS results. Validation of each experiment's ability to reproduce identical samples is shown, and subsequent comparisons are made to publicly available unfolded data. An additional common setup, using the SHERPA Monte-Carlo generation package, is similarly validated and compared.

Journal of High Energy Physics

The charge-parity (CP) structure of the Yukawa interaction between the Higgs (H) boson and the top quark is measured in a data sample enriched in the t H and tH associated production, using 138 fb− 1 of data collected in proton-proton collisions at= 13 TeV by the CMS experiment at the CERN LHC. The study targets events where the H boson decays via H→ WW or H→ ττ and the top quarks decay via t→ Wb: the W bosons decay either leptonically or hadronically, and final states characterized by the presence of at least two leptons are studied. Machine learning techniques are applied to these final states to enhance the separation of CP-even from CP-odd scenarios. Two-dimensional confidence regions are set on κ t and t, which are respectively defined as the CP-even and CP-odd top-Higgs Yukawa coupling modifiers. No significant fractional CP-odd contributions, parameterized by the quantity|| are observed; the …

Journal of Instrumentation

The Large Hadron Collider at CERN will undergo an upgrade in order to increase its luminosity to 7.5× 1034 cm− 2s− 1. The increased luminosity during this High-Luminosity running phase, starting around 2029, means a higher rate of proton-proton interactions, hence a larger ionizing dose and particle fluence for the detectors. The current tracking system of the CMS experiment will be fully replaced in order to cope with the new operating conditions. Prototype planar pixel sensors for the CMS Inner Tracker with square 50 μm× 50 μm and rectangular 100 μm× 25 μm pixels read out by the RD53A chip were characterized in the lab and at the DESY-II testbeam facility in order to identify designs that meet the requirements of CMS during the High-Luminosity running phase. A spatial resolution of approximately 3.4 μm (2 μm) is obtained using the modules with 50 μm× 50 μm (100 μm× 25 μm) pixels at the optimal angle …

Physical Review D

For the first time at LHC energies, the forward rapidity gap spectra from proton-lead collisions for both proton and lead dissociation processes are presented. The analysis is performed over 10.4 units of pseudorapidity at a center-of-mass energy per nucleon pair of s NN= 8.16 TeV, almost 300 times higher than in previous measurements of diffractive production in proton-nucleus collisions. For lead dissociation processes, which correspond to the pomeron-lead event topology, the epos-lhc generator predictions are a factor of 2 below the data, but the model gives a reasonable description of the rapidity gap spectrum shape. For the pomeron-proton topology, the epos-lhc, qgsjet ii, and hijing predictions are all at least a factor of 5 lower than the data. The latter effect might be explained by a significant contribution of ultraperipheral photoproduction events mimicking the signature of diffractive processes. These data may be of significant help in understanding the high energy limit of quantum chromodynamics and for modeling cosmic ray air showers.

Encuentros multidisciplinares

En este artículo se presenta el origen, la estructura, la organización, los objetivos, así como las actividades principales de la Asociación Española para el Avance de la Ciencia (AEAC), junto con una reflexión final sobre las dimensiones éticas de la investigación científica. Como se puede comprobar en el desarrollo de las distintas secciones, se trata de una organización única a nivel nacional en su objetivo declarado de establecer un puente permanente entre ciencia y sociedad. La consideración de la ciencia como un derecho de la ciudadanía y la defensa del conocimiento científico como herramienta de progreso y justicia social son rasgos que singularizan a la AEAC y que se manifiestan en las acciones y actividades que se desarrollan en su seno

Journal of High Energy Physics

A search is reported for heavy resonances and quantum black holes decaying into eμ, eτ, and μτ final states in proton-proton collision data recorded by the CMS experiment at the CERN LHC during 2016–2018 at= 13 TeV, corresponding to an integrated luminosity of 138 fb− 1. The eμ, eτ, and μτ invariant mass spectra are reconstructed, and no evidence is found for physics beyond the standard model. Upper limits are set at 95% confidence level on the product of the cross section and branching fraction for lepton flavor violating signals. Three benchmark signals are studied: resonant τ sneutrino production in R parity violating supersymmetric models, heavy Z′ gauge bosons with lepton flavor violating decays, and nonresonant quantum black hole production in models with extra spatial dimensions. Resonant τ sneutrinos are excluded for masses up to 4.2 TeV in the eμ channel, 3.7 TeV in the eτ channel, and 3 …

Physics Letters B

The first measurements of the Fourier coefficients (V n Δ) of the azimuthal distributions of charged hadrons emitted from photon-proton (γp) interactions are presented. The data are extracted from 68.8 nb− 1 of ultra-peripheral proton-lead (pPb) collisions at s NN= 8.16 TeV using the CMS detector. The high energy lead ions produce a flux of photons that can interact with the oncoming proton. This γp system provides a set of unique initial conditions with multiplicity lower than in photon-lead collisions but comparable to recent electron-positron and electron-proton data. The V n Δ coefficients are presented in ranges of event multiplicity and transverse momentum (p T) and are compared to corresponding hadronic minimum bias pPb results. For a given multiplicity range, the mean p T of charged particles is smaller in γp than in pPb collisions. For both the γp and pPb samples, V 1 Δ is negative, V 2 Δ is positive, and V 3 …

Physics Letters B

A precise measurement of the invisible width of the Z boson produced in proton-proton collisions at a center-of-mass energy of 13 TeV is presented using data recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 36.3 fb− 1. The result is obtained from a simultaneous fit to kinematic distributions for two data samples of Z boson plus jets: one dominated by Z boson decays to invisible particles and the other by Z boson decays to muon and electron pairs. The invisible width is measured to be 523±3 (stat)±16 (syst) MeV. This result is the first precise measurement of the invisible width of the Z boson at a hadron collider, and is the single most precise direct measurement to date, competitive with the combined result of the direct measurements from the LEP experiments.

Journal of High Energy Physics

A search for the exotic decay of the Higgs boson to a pair of light pseudoscalars, each of which subsequently decays into a pair of photons, is presented. The search uses data from proton-proton collisions at= 13 TeV recorded with the CMS detector at the LHC that corresponds to an integrated luminosity of 132 fb− 1. The analysis probes pseudoscalar bosons with masses in the range 15–62 GeV, coming from the Higgs boson decay, which leads to four well-isolated photons in the final state. No significant deviation from the background-only hypothesis is observed. Upper limits are set on the product of the Higgs boson production cross section and branching fraction into four photons. The observed (expected) limits range from 0.80 (1.00) fb for a pseudoscalar boson mass of 15 GeV to 0.26 (0.24) fb for a mass of 62 GeV at 95% confidence level.

Nature

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes, and molecular mechanisms that are often specific to cell type,. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10−8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster …

Nature

Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion Nature. 2024 Feb 9. doi: 10.1038/s41586-024-07164-y. Online ahead of print. Authors Yu-Hwa Huang 1 , Chen Zhu # 2 , Yasuyuki Kondo # 1 , Ana C Anderson 2 , Amit Gandhi 1 , Andrew Russell 3 , Stephanie K Dougan 4 , Britt-Sabina Petersen 5 , Espen Melum 1 6 , Thomas Pertel 2 , Kiera L Clayton 7 , Monika Raab 8 , Qiang Chen 9 , Nicole Beauchemin 10 , Paul J Yazaki 11 , Michal Pyzik 1 , Mario A Ostrowski 7 12 , Jonathan N Glickman 13 , Christopher E Rudd 8 , Hidde L Ploegh 4 , Andre Franke 5 , Gregory A Petsko 3 , Vijay K Kuchroo 2 , Richard S Blumberg 14 Affiliations 1 Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, 02115, Massachusetts, USA. 2 …

Nature

화학공학소재연구정보센터(CHERIC) | 연구정보 | 문헌DB | 학술지 검색 화학공학소재연구정보 센터 홈 로그인 로그아웃 연락처 사이트맵 센터 센터소개 회원가입/정보수정 뉴스 공지사항 연구 동향 학회참관기 우수연구자소개 취업정보 연구정보 문헌DB KDB Compound Search 전문연구 정보 동영상 심포지움 자료 연구성과보고서 저널정보 논문 작성법 참고문헌DB 분석기기DB 화학 공정DB PSPDB 연구자지식지도 상태도정보 교육정보 사이버강의-학부 사이버강의-대학원 실무 강좌 강의자료 링크 교육자료 링크 사이버실험실 물성측정실험 매뉴얼 커뮤니티 공학포럼 카페 신진연구자인터뷰 리소스 특허정보 술어DB 관련법령 자격증정보 성과소개서 연구보고서 문헌DB 학술지 검색 학술대회 발표논문집 최신 국내 저널 최신 리뷰페이퍼 KDB Periodic Table of Elements Unit Conversion Universal Constants Pure Component Properties Binary Vapor-Liquid Equil. Data Calculation Modules Research Articles Citing KDB Compound Search …

Nature

EconPapers: Why it was right to reject the Anthropocene as a geological epoch EconPapers Economics at your fingertips EconPapers Home About EconPapers Working Papers Journal Articles Books and Chapters Software Components Authors JEL codes New Economics Papers Advanced Search EconPapers FAQ Archive maintainers FAQ Cookies at EconPapers Format for printing The RePEc blog The RePEc plagiarism page Why it was right to reject the Anthropocene as a geological epoch Mark Maslin (), Matthew Edgeworth, Erle C. Ellis and Philip L. Gibbard Nature, 2024, vol. 629, issue 8010, 41-41 Abstract: Letter to the Editor Keywords: Geology; Environmental sciences; Climate change; Sustainability (search for similar items in EconPapers) Date: 2024 References: Add references at CitEc Citations: Downloads: (external link) https://www.nature.com/articles/d41586-024-01268-1 Abstract (text/html) Access to …

Nature

Trees structure the Earth’s most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations, , , , – in closed-canopy, structurally intact old-growth tropical forests in Africa, Amazonia and Southeast Asia. We estimate that 2.2%, 2.2% and 2.3% of species comprise 50% of the tropical trees in these regions, respectively. Extrapolating across all closed-canopy tropical forests, we estimate that just 1,053 species comprise half of Earth’s 800 billion tropical trees with trunk diameters of at least 10 cm. Despite …

Nature

Angiosperms are the cornerstone of most terrestrial ecosystems and human livelihoods,. A robust understanding of angiosperm evolution is required to explain their rise to ecological dominance. So far, the angiosperm tree of life has been determined primarily by means of analyses of the plastid genome,. Many studies have drawn on this foundational work, such as classification and first insights into angiosperm diversification since their Mesozoic origins, –. However, the limited and biased sampling of both taxa and genomes undermines confidence in the tree and its implications. Here, we build the tree of life for almost 8,000 (about 60%) angiosperm genera using a standardized set of 353 nuclear genes. This 15-fold increase in genus-level sampling relative to comparable nuclear studies provides a critical test of earlier results and brings notable change to key groups, especially in rosids, while substantiating …

Nature

Van der Waals encapsulation of two-dimensional materials in hexagonal boron nitride (hBN) stacks is a promising way to create ultrahigh-performance electronic devices 1, 2, 3, 4. However, contemporary approaches for achieving van der Waals encapsulation, which involve artificial layer stacking using mechanical transfer techniques, are difficult to control, prone to contamination and unscalable. Here we report the transfer-free direct growth of high-quality graphene nanoribbons (GNRs) in hBN stacks. The as-grown embedded GNRs exhibit highly desirable features being ultralong (up to 0.25 mm), ultranarrow (< 5 nm) and homochiral with zigzag edges. Our atomistic simulations show that the mechanism underlying the embedded growth involves ultralow GNR friction when sliding between AA′-stacked hBN layers. Using the grown structures, we demonstrate the transfer-free fabrication of embedded GNR field …

Nature

Scientific evidence regularly guides policy decisions, with behavioural science increasingly part of this process. In April 2020, an influential paper proposed 19 policy recommendations (‘claims’) detailing how evidence from behavioural science could contribute to efforts to reduce impacts and end the COVID-19 pandemic. Here we assess 747 pandemic-related research articles that empirically investigated those claims. We report the scale of evidence and whether evidence supports them to indicate applicability for policymaking. Two independent teams, involving 72 reviewers, found evidence for 18 of 19 claims, with both teams finding evidence supporting 16 (89%) of those 18 claims. The strongest evidence supported claims that anticipated culture, polarization and misinformation would be associated with policy effectiveness. Claims suggesting trusted leaders and positive social norms increased adherence to …

Nature

Topology, – and interactions are foundational concepts in the modern understanding of quantum matter. Their nexus yields three important research directions: (1) the competition between distinct interactions, as in several intertwined phases, (2) the interplay between interactions and topology that drives the phenomena in twisted layered materials and topological magnets, and (3) the coalescence of several topological orders to generate distinct novel phases. The first two examples have grown into major areas of research, although the last example remains mostly unexplored, mainly because of the lack of a material platform for experimental studies. Here, using tunnelling microscopy, photoemission spectroscopy and a theoretical analysis, we unveil a ‘hybrid’ topological phase of matter in the simple elemental-solid arsenic. Through a unique bulk-surface-edge correspondence, we uncover that arsenic features a …

Nature

The Middle to Upper Palaeolithic transition in Europe is associated with the regional disappearance of Neanderthals and the spread of Homo sapiens. Late Neanderthals persisted in western Europe several millennia after the occurrence of H. sapiens in eastern Europe1. Local hybridization between the two groups occurred2, but not on all occasions3. Archaeological evidence also indicates the presence of several technocomplexes during this transition, complicating our understanding and the association of behavioural adaptations with specific hominin groups4. One such technocomplex for which the makers are unknown is the Lincombian–Ranisian–Jerzmanowician (LRJ), which has been described in northwestern and central Europe5–8. Here we present the morphological and proteomic taxonomic identification, mitochondrial DNA analysis and direct radiocarbon dating of human remains directly associated …

Nature

The glymphatic movement of fluid through the brain removes metabolic waste, , –. Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and attenuates pathology in mouse models of Alzheimer’s disease, , –. Here we show that multisensory gamma stimulation promotes the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of Alzheimer’s disease. Influx of cerebrospinal fluid was associated with increased aquaporin-4 polarization along astrocytic endfeet and dilated meningeal lymphatic vessels. Inhibiting glymphatic clearance abolished the removal of amyloid by multisensory 40 Hz stimulation. Using chemogenetic manipulation and a genetically encoded sensor for neuropeptide signalling, we found that vasoactive intestinal peptide interneurons facilitate glymphatic clearance by regulating arterial pulsatility. Our findings …

Nature

Western Eurasia witnessed several large-scale human migrations during the Holocene, , , –. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness …

Nature

Determining the structure and phenotypic context of molecules detected in untargeted metabolomics experiments remains challenging. Here we present reverse metabolomics as a discovery strategy, whereby tandem mass spectrometry spectra acquired from newly synthesized compounds are searched for in public metabolomics datasets to uncover phenotypic associations. To demonstrate the concept, we broadly synthesized and explored multiple classes of metabolites in humans, including N-acyl amides, fatty acid esters of hydroxy fatty acids, bile acid esters and conjugated bile acids. Using repository-scale analysis,, we discovered that some conjugated bile acids are associated with inflammatory bowel disease (IBD). Validation using four distinct human IBD cohorts showed that cholic acids conjugated to Glu, Ile/Leu, Phe, Thr, Trp or Tyr are increased in Crohn’s disease. Several of these compounds and …

Nature

Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies. Here we studied 246,102 single epithelial cells from 16 early-stage LUADs and 47 matched normal lung samples. Epithelial cells comprised diverse normal and cancer cell states, and diversity among cancer cells was strongly linked to LUAD-specific oncogenic drivers. KRAS mutant cancer cells showed distinct transcriptional features, reduced differentiation and low levels of aneuploidy. Non-malignant areas surrounding human LUAD samples were enriched with alveolar intermediate cells that displayed elevated KRT8 expression (termed KRT8+ alveolar intermediate cells (KACs) here), reduced differentiation, increased plasticity and driver KRAS mutations. Expression profiles of KACs were enriched in lung precancer cells and in LUAD cells and signified poor survival …

Nature

Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and are critical contributors to morbidity and mortality in older people. Deciphering the molecular mechanisms underlying sarcopenia has major implications for understanding human ageing. Yet, progress has been slow, partly due to the difficulties of characterizing skeletal muscle niche heterogeneity (whereby myofibres are the most abundant) and obtaining well-characterized human samples,. Here we generate a single-cell/single-nucleus transcriptomic and chromatin accessibility map of human limb skeletal muscles encompassing over 387,000 cells/nuclei from individuals aged 15 to 99 years with distinct fitness and frailty levels. We describe how cell populations change during ageing, including the emergence of new populations in older people, and the cell-specific and multicellular network features (at the transcriptomic …

Nature

Myeloid cells are known to suppress antitumour immunity. However, the molecular drivers of immunosuppressive myeloid cell states are not well defined. Here we used single-cell RNA sequencing of human and mouse non-small cell lung cancer (NSCLC) lesions, and found that in both species the type 2 cytokine interleukin-4 (IL-4) was predicted to be the primary driver of the tumour-infiltrating monocyte-derived macrophage phenotype. Using a panel of conditional knockout mice, we found that only deletion of the IL-4 receptor IL-4Rα in early myeloid progenitors in bone marrow reduced tumour burden, whereas deletion of IL-4Rα in downstream mature myeloid cells had no effect. Mechanistically, IL-4 derived from bone marrow basophils and eosinophils acted on granulocyte-monocyte progenitors to transcriptionally programme the development of immunosuppressive tumour-promoting myeloid cells …

Nature

EconPapers: Urban trees: how to maximize their benefits for humans and the environment EconPapers Economics at your fingertips EconPapers Home About EconPapers Working Papers Journal Articles Books and Chapters Software Components Authors JEL codes New Economics Papers Advanced Search EconPapers FAQ Archive maintainers FAQ Cookies at EconPapers Format for printing The RePEc blog The RePEc plagiarism page Urban trees: how to maximize their benefits for humans and the environment Lina Tang (), Guofan Shao and Peter M. Groffman Nature, 2024, vol. 626, issue 7998, 261-261 Abstract: Letter to the Editor Keywords: Policy; Sustainability; Environmental sciences (search for similar items in EconPapers) Date: 2024 References: Add references at CitEc Citations: Track citations by RSS feed Downloads: (external link) https://www.nature.com/articles/d41586-024-00300-8 Abstract (text/…

Nature

Crop production is a large source of atmospheric ammonia (NH 3), which poses risks to air quality, human health and ecosystems 1, 2, 3, 4, 5. However, estimating global NH 3 emissions from croplands is subject to uncertainties because of data limitations, thereby limiting the accurate identification of mitigation options and efficacy 4, 5. Here we develop a machine learning model for generating crop-specific and spatially explicit NH 3 emission factors globally (5-arcmin resolution) based on a compiled dataset of field observations. We show that global NH 3 emissions from rice, wheat and maize fields in 2018 were 4.3±1.0 Tg N yr− 1, lower than previous estimates that did not fully consider fertilizer management practices 6, 7, 8, 9. Furthermore, spatially optimizing fertilizer management, as guided by the machine learning model, has the potential to reduce the NH 3 emissions by about 38%(1.6±0.4 Tg N yr− 1 …

Nature

Understanding the formation and stabilization mechanisms of soil organic carbon (SOC) is important for managing land carbon (C) and mitigating climate change. Tao et al. 1 reported that microbial C use efficiency (CUE) is the primary determinant of global SOC storage and that the relative impact of plant C inputs on SOC is minor. Although soil microbes undoubtedly play an important role in SOC cycling, we are concerned about the robustness of the approach taken by Tao et al. 1. The potential biases in their analyses may lead to misleading, model-dependent results.An important piece of evidence in support of an empirical relationship between CUE and SOC stems from a meta-analysis based on 132 paired CUE and SOC measurements. Tao et al. 1 applied a linear mixed-effects model to this dataset that included CUE, mean annual temperature (MAT), soil depth and random effects and explained 55% of the …

Nature

Western Eurasia witnessed several large-scale human migrations during the Holocene, , , –. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness …