Adrian L Harris
University of Oxford
H-index: 205
Europe-United Kingdom
Description
Adrian L Harris, With an exceptional h-index of 205 and a recent h-index of 81 (since 2020), a distinguished researcher at University of Oxford, specializes in the field of Breast cancer, angiogenesis, hypoxia, metabolism.
His recent articles reflect a diverse array of research interests and contributions to the field:
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response
A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Abstract B056: Chronic hypoxia in TNBC breast cancer induces development of a novel population of CD24+/CD49b-high cells characterized by high expression of CST1
New role of fat-free mass in cancer risk linked with genetic predisposition
Integrating Smartwatches in Community Mental Health Services for Severe Mental Illness: A Case Series
Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study
Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression
Professor Information
University | University of Oxford |
---|---|
Position | Professor of Medical Oncology |
Citations(all) | 179847 |
Citations(since 2020) | 39684 |
Cited By | 156948 |
hIndex(all) | 205 |
hIndex(since 2020) | 81 |
i10Index(all) | 1113 |
i10Index(since 2020) | 582 |
University Profile Page | University of Oxford |
Research & Interests List
Breast cancer
angiogenesis
hypoxia
metabolism
Top articles of Adrian L Harris
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response
BackgroundPDE6H encodes PDE6γ′, the inhibitory subunit of the cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition of PDE6, which has been widely studied for its role in light transduction, increases cGMP levels. The purpose of this study is to characterise the role of PDE6H in cancer cell growth.MethodsFrom an siRNA screen for 487 genes involved in metabolism, PDE6H was identified as a controller of cell cycle progression in HCT116 cells. Role of PDE6H in cancer cell growth and metabolism was studied through the effects of its depletion on levels of cell cycle controllers, mTOR effectors, metabolite levels, and metabolic energy assays. Effect of PDE6H deletion on tumour growth was also studied in a xenograft model.ResultsPDE6H knockout resulted in an increase of intracellular cGMP levels, as well as changes to the levels of nucleotides and key energy metabolism intermediates …
Authors
Ceren Yalaz,Esther Bridges,Nasullah K Alham,Christos E Zois,Jianzhou Chen,Karim Bensaad,Ana Miar,Elisabete Pires,Ruth J Muschel,James SO McCullagh,Adrian L Harris
Journal
Cancer & Metabolism
Published Date
2024/2/13
A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding
Uterine fibroids (UFs), benign tumours prevalent in up to 80% of women of reproductive age, are associated with significant morbidity, including abnormal uterine bleeding, pain and infertility. Despite identification of key genomic alterations in MED12 and HMGA2, the pathogenic mechanisms underlying UFs and heavy menstrual bleeding (HMB) remain poorly understood. To correlate systematically genetic, transcriptional and proteomic phenotypes, our study involved an integrative analysis of fibroid, myometrium and endometrium tissues from 137 patients, utilising genome-wide SNP arrays, targeted sequencing, RNA sequencing and proteomics. Our findings reveal 39.7% of UFs possess MED12 mutations, alongside novel variants in genes such as COL4A5 and COL4A6. Multi-omics factor analysis of integrated protein and mRNA highlighted differential regulation related to extracellular matrix remodelling, proteolysis and homeostasis in fibroid versus myometrium tissues, and distinct gene sets associated with RNA splicing in the endometrium of patients with HMB, particularly in MED12-mutated fibroids. Our study proposes a model, which is supported by in vivo evidence, where altered signalling of MED12-mutated fibroids influences RNA transcript isoform expression in endometrium, potentially leading to abnormal uterine bleeding. This integrative approach unravels complex molecular pathways in UF pathogenesis and HMB, offering novel insights for targeted therapeutic development.
Authors
Chen-Yi Wang,Martin Philpott,Darragh P O'Brien,Anne P Ndungu,Jessica Malzahn,Marina Maritati,Neelam Mehta,Vicki Gamble,Beatriz Martinez-Burgo,Sarah Bonham,Roman Fischer,Kurtis Garbutt,Christian M Becker,Sanjiv Manek,Adrian L Harris,Frank Sacher,Maik Obendorf,Nicole Schmidt,Jörg Müller,Thomas M Zollner,Krina T Zondervan,Benedikt M Kessler,Udo Oppermann,Adam P Cribbs
Journal
bioRxiv
Published Date
2024
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which …
Authors
Joshua A Welsh,Deborah CI Goberdhan,Lorraine O'Driscoll,Edit I Buzas,Cherie Blenkiron,Benedetta Bussolati,Houjian Cai,Dolores Di Vizio,Tom AP Driedonks,Uta Erdbrügger,Juan M Falcon‐Perez,Qing‐Ling Fu,Andrew F Hill,Metka Lenassi,Sai Kiang Lim,Mỹ G Mahoney,Sujata Mohanty,Andreas Möller,Rienk Nieuwland,Takahiro Ochiya,Susmita Sahoo,Ana C Torrecilhas,Lei Zheng,Andries Zijlstra,Sarah Abuelreich,Reem Bagabas,Paolo Bergese,Esther M Bridges,Marco Brucale,Dylan Burger,Randy P Carney,Emanuele Cocucci,Rossella Crescitelli,Edveena Hanser,Adrian L Harris,Norman J Haughey,An Hendrix,Alexander R Ivanov,Tijana Jovanovic‐Talisman,Nicole A Kruh‐Garcia,Vroniqa Ku'ulei‐Lyn Faustino,Diego Kyburz,Cecilia Lässer,Kathleen M Lennon,Jan Lötvall,Adam L Maddox,Elena S Martens‐Uzunova,Rachel R Mizenko,Lauren A Newman,Andrea Ridolfi,Eva Rohde,Tatu Rojalin,Andrew Rowland,Andras Saftics,Ursula S Sandau,Julie A Saugstad,Faezeh Shekari,Simon Swift,Dmitry Ter‐Ovanesyan,Juan P Tosar,Zivile Useckaite,Francesco Valle,Zoltan Varga,Edwin van der Pol,Martijn JC van Herwijnen,Marca HM Wauben,Ann M Wehman,Sarah Williams,Andrea Zendrini,Alan J Zimmerman,MISEV Consortium,Sarah Abuelreich,Samar Ahmad,Dina AK Ahmed,Sarah H Ahmed,Elena Aikawa,Naveed Akbar,Kazunari Akiyoshi,David P Al‐Adra,Maimonah E Al‐Masawa,Manuel Albanese,Ainhoa Alberro,María José Alcaraz,Jen Alexander‐Brett,Kimberley L Alexander,Nilufar Ali,Faisal J Alibhai,Susann Allelein,Mark C Allenby,Fausto Almeida,Luis Pereira de Almeida,Sameh W Almousa,Nihal Altan‐Bonnet,Wanessa F Altei,Gloria Alvarez‐Llamas,Cora L Alvarez,Hyo Jung An,Krishnan Anand,Samir EL Andaloussi,Johnathon D Anderson,Ramaroson Andriantsitohaina,Khairul I Ansari,Achille Anselmo,Anna Antoniou,Farrukh Aqil,Tanina Arab,Fabienne Archer,Syrine Arif,David A Armstrong,Onno J Arntz,Pierre Arsène,Luis Arteaga‐Blanco,Nandini Asokan,Trude Aspelin,Georgia K Atkin‐Smith,Dimitri Aubert,Kanchana K Ayyar,Maryam Azlan,Ioannis Azoidis,Anaïs Bécot,Jean‐Marie Bach,Daniel Bachurski,Seoyoon Bae,Reem Bagabas,Roger Olofsson Bagge,Monika Baj‐Krzyworzeka,Leonora Balaj,Carolina Balbi,Bas WM van Balkom,Abhijna R Ballal,Afsareen Bano,Sébastien Banzet,Yonis Bare,Lucio Barile,Bahnisikha Barman,Isabel Barranco,Valeria Barreca,Geneviève Bart,Natasha S Barteneva,Manuela Basso,Mona Batish,Natalie R Bauer,Amy A Baxter,Wilfried W Bazié,Erica Bazzan,Joel EJ Beaumont,Mary Bebawy,Maarten P Bebelman,Apolonija Bedina‐Zavec,Danielle J Beetler
Journal
Journal of extracellular vesicles
Published Date
2024/2
Abstract B056: Chronic hypoxia in TNBC breast cancer induces development of a novel population of CD24+/CD49b-high cells characterized by high expression of CST1
Triple-negative breast cancer (TNBC) is the subtype of breast cancer that has the worst clinical outcome due to the absence of specific targeting agents. TNBC is highly heterogeneous and within the tumor microenvironment, hypoxia emerges as a pivotal factor contributing to its aggressive biology. Solid tumors experience a fluctuating oxygen supply, leading to the formation of zones with prolonged oxygen deprivation. There have been few studies describing the response to chronic hypoxia [7-14 days] and this project investigates how chronic hypoxia contributes to tumour heterogeneity in a temporal manner. We performed scRNA-seq analysis on MDA-MB-231 cells subjected to a 14-day hypoxia treatment at 1% oxygen. We collected samples from both normoxia and hypoxia conditions on Days 1, 2, 7, and 14. A total of 40,000 cells were sequenced. There were 6 hypoxic cell clusters which evolved over the time …
Authors
May Sin Ke,Badran Elshenawy,Anjali Arora,Helen Sheldon,Adrian Harris,Francesca Buffa
Journal
Cancer Research
Published Date
2024/2/1
New role of fat-free mass in cancer risk linked with genetic predisposition
Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMBC (p = 1.56E–17 and 1.78E–11) and WBFFM (p = 2.88E–08 and 8.24E–12), highlighting splice variants of …
Authors
Benjamin HL Harris,Matteo Di Giovannantonio,Ping Zhang,David A Harris,Simon R Lord,Naomi E Allen,Tim S Maughan,Richard J Bryant,Adrian L Harris,Gareth L Bond,Francesca M Buffa
Journal
Scientific reports
Published Date
2024/3/27
Integrating Smartwatches in Community Mental Health Services for Severe Mental Illness: A Case Series
Objective:This case series explored the integration of smartwatches in a community mental health service to support severe mental illness (SMI) management and intervention. We examined whether biometric data provided by smartwatches could help to predict relapse and inform treatment decisions.Method:Four SMI patients were selected from a prior study. Clinicians accessed patients’ biometric data (activity, sleep, heart rate, and electrodermal activity) through smartwatches.Results:: Changes in circadian rhythm and electrodermal activity preceded hospitalization in two cases. Additionally, smartwatch data was effectively used to guide targeted interventions, improving patient treatment outcomes.Conclusion:Integrating smartwatches in community mental health services offers promise as adjunct tools for severe mental illness management. However, ethical considerations on data privacy and technology reliance require further evaluation.
Authors
Daniel Talbot,David Johnston,Rachael Foord,Achim Casties,Nola Viaphay,Ahmed Tohamy,NV Leeuwen,Jodie Sinclair,Anthony Harris
Published Date
2024/1/30
Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study
Deregulated metabolism is one of the hallmarks of cancer. It is well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen is available and mitochondrial respiration is functional. However, the lower energy efficiency of aerobic glycolysis with respect to mitochondrial respiration makes this behaviour, namely the Warburg effect, counter-intuitive, although it has now been recognized as source of anabolic precursors. On the other hand, there is evidence that oxygenated tumour cells could be fuelled by exogenous lactate produced from glycolysis. We employed a multi-scale approach that integrates multi-agent modelling, diffusion-reaction, stoichiometric equations, and Boolean networks to study metabolic cooperation between hypoxic and oxygenated cells exposed to varying oxygen, nutrient, and inhibitor concentrations. The results show that the cooperation reduces the depletion of environmental glucose, resulting in an overall advantage of using aerobic glycolysis. In addition, the oxygen level was found to be decreased by symbiosis, promoting a further shift towards anaerobic glycolysis. However, the oxygenated and hypoxic populations may gradually reach quasi-equilibrium. A sensitivity analysis using Latin hypercube sampling and partial rank correlation shows that the symbiotic dynamics depends on properties of the specific cell such as the minimum glucose level needed for glycolysis. Our results suggest that strategies that block glucose transporters may be more effective to reduce tumour growth than those blocking lactate intake transporters.
Authors
Pahala Gedara Jayathilake,Pedro Victori,Clara E Pavillet,Chang Heon Lee,Dimitrios Voukantsis,Ana Miar,Anjali Arora,Adrian L Harris,Karl J Morten,Francesca M Buffa
Journal
PLOS Computational Biology
Published Date
2024/3/15
Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression
Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness in young children and elderly individuals. Our knowledge of the host pathways that define susceptibility to infection and disease severity are limited. Hypoxia inducible factors (HIFs) define metabolic responses to low oxygen and regulate inflammatory responses in the lower respiratory tract. We demonstrate a role for HIFs to suppress RSV entry and RNA replication. We show that hypoxia and HIF prolyl-hydroxylase inhibitors reduce the expression of the RSV entry receptor nucleolin and inhibit viral cell-cell fusion. We identify a HIF regulated microRNA, miR-494, that regulates nucleolin expression. In RSV-infected mice, treatment with the clinically approved HIF prolyl-hydroxylase inhibitor, Daprodustat, reduced the level of infectious virus and infiltrating monocytes and neutrophils in the lung. This study highlights a role for …
Authors
Xiaodong Zhuang,Giulia Gallo,Parul Sharma,Jiyeon Ha,Andrea Magri,Helene Borrmann,James M Harris,Senko Tsukuda,Eleanor Bentley,Adam Kirby,Simon De Neck,Hongbing Yang,Peter Balfe,Peter AC Wing,David Matthews,Adrian L Harris,Anja Kipar,James P Stewart,Dalan Bailey,Jane A McKeating
Journal
Iscience
Published Date
2024/1/19
Professor FAQs
What is Adrian L Harris's h-index at University of Oxford?
The h-index of Adrian L Harris has been 81 since 2020 and 205 in total.
What are Adrian L Harris's top articles?
The articles with the titles of
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response
A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Abstract B056: Chronic hypoxia in TNBC breast cancer induces development of a novel population of CD24+/CD49b-high cells characterized by high expression of CST1
New role of fat-free mass in cancer risk linked with genetic predisposition
Integrating Smartwatches in Community Mental Health Services for Severe Mental Illness: A Case Series
Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study
Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression
...
are the top articles of Adrian L Harris at University of Oxford.
What are Adrian L Harris's research interests?
The research interests of Adrian L Harris are: Breast cancer, angiogenesis, hypoxia, metabolism
What is Adrian L Harris's total number of citations?
Adrian L Harris has 179,847 citations in total.
What are the co-authors of Adrian L Harris?
The co-authors of Adrian L Harris are Roy Bicknell, Catharine West, Francesco Pezzella, Russell Leek, Francesca Buffa, Ji-Liang Li.